Further Characterization of the Mitigation of Radiation Lethality by Protective Wounding

There continues to be a major effort in the United States to develop mitigators for the treatment of mass casualties that received high-intensity acute ionizing radiation exposures from the detonation of an improvised nuclear device during a radiological terrorist attack. The ideal countermeasure should be effective when administered after exposure, and over a wide range of absorbed doses. We have previously shown that the administration of a subcutaneous incision of a defined length, if administered within minutes after irradiation, protected young adult female C57BL/6 mice against radiation-induced lethality, and increased survival after total-body exposure to an LD50/30 X-ray dose from 50% to over 90%. We refer to this approach as "protective wounding". In this article, we report on our efforts to further optimize, characterize and demonstrate the validity of the protective wounding response by comparing the response of female and male mice, varying the radiation dose, the size of the wound, and the timing of wounding with respect to administration of the radiation dose. Both male and female mice that received a subcutaneous incision after irradiation were significantly protected from radiation lethality. We observed that the extent of protection against lethality after an LD50/30 X-ray dose was independent of the size of the subcutaneous cut, and that a 3 mm subcutaneous incision is effective at enhancing the survival of mice exposed to a broad range of radiation doses (LD15-LD100). Over the range of 6.2-6.7 Gy, the increase in survival observed in mice that received an incision was associated with an enhanced recovery of hematopoiesis. The enhanced rate of recovery of hematopoiesis was preceded by an increase in the production of a select group of cytokines. Thus, a thorough knowledge of the timing of the cytokine cascade after wounding could aid in the development of novel pharmacological radiation countermeasures that can be administered several days after the actual radiation exposure

Migrating to Cloud-Native Architectures Using Microservices: An Experience Report

Migration to the cloud has been a popular topic in industry and academia in recent years. Despite many benefits that the cloud presents, such as high availability and scalability, most of the on-premise application architectures are not ready to fully exploit the benefits of this environment, and adapting them to this environment is a non-trivial task. Microservices have appeared recently as novel architectural styles that are native to the cloud. These cloud-native architectures can facilitate migrating on-premise architectures to fully benefit from the cloud environments because non-functional attributes, like scalability, are inherent in this style. The existing approaches on cloud migration does not mostly consider cloud-native architectures as their first-class citizens. As a result, the final product may not meet its primary drivers for migration. In this paper, we intend to report our experience and lessons learned in an ongoing project on migrating a monolithic on-premise software architecture to microservices. We concluded that microservices is not a one-fit-all solution as it introduces new complexities to the system, and many factors, such as distribution complexities, should be considered before adopting this style. However, if adopted in a context that needs high flexibility in terms of scalability and availability, it can deliver its promised benefits

Analysis of cosmic ray variations observed by the CARPET in association with solar flares in 2011-2012

The CARPET cosmic ray detector was installed on April 2006 at CASLEO (Complejo Astronmico El Leoncito) at the Argentinean Andes (31.8S, 69.3W, 2550 m, Rc=9.65 GV). This instrument was developed within an international cooperation between the Lebedev Physical Institute RAS (LPI; Russia), the Centro de Radio Astronomia e Astrofsica Mackenzie (CRAAM; Brazil) and the Complejo Astronmico el Leoncito (CASLEO; Argentina). In this paper we present results of analysis of cosmic ray variations recorded by the CARPET during increased solar flare activity in 2011-2012. Available solar and interplanetary medium observational data obtained onboard GOES, FERMI, ISS, as well as cosmic ray measurements by ground-based neutron monitor network were also used in the present analysis.Fil: Makhmutov, V.. Lebedev Physical Institute; Rusia. Universidade Presbiteriana Mackenzie; BrasilFil: Raulin, J. P.. Universidade Presbiteriana Mackenzie; BrasilFil: De Mendonca, R. R. S.. National Institute for Space Research; BrasilFil: Bazilevskaya, G. A.. Lebedev Physical Institute; RusiaFil: Correia, E.. Universidade Presbiteriana Mackenzie; Brasil. National Institute for Space Research; BrasilFil: Kaufmann, Pierre. Universidade Presbiteriana Mackenzie; BrasilFil: Marun, Adolfo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Complejo Astronómico "El Leoncito". Universidad Nacional de Córdoba. Complejo Astronómico "El Leoncito". Universidad Nacional de la Plata. Complejo Astronómico "El Leoncito". Universidad Nacional de San Juan. Complejo Astronómico "El Leoncito"; ArgentinaFil: Fernandez, German Enzo Leonel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Complejo Astronómico "El Leoncito". Universidad Nacional de Córdoba. Complejo Astronómico "El Leoncito". Universidad Nacional de la Plata. Complejo Astronómico "El Leoncito". Universidad Nacional de San Juan. Complejo Astronómico "El Leoncito"; ArgentinaFil: Echer, E.. National Institute for Space Research; Brasi

INPE's crop survey program using combined LANDSAT and aircraft data

There are no author-identified significant results in this report

Avaliação da Influência da Mata Ciliar na Bacia do Rio Siriri, Sergipe, sobre o Escoamento Superficial e Produção de Sedimentos via Modelo SWAT.

A necessidade cada vez mais crescente por recursos naturais fez crescer o desmatamento em bacias hidrográficas, principalmente nas áreas de nascente e da mata ciliar. A mata ciliar contribui para o incremento de recarga para os aquíferos, redução da energia das águas superficiais e da carga poluidora que chega até o rio. Faz-se necessário, portanto, determinar a área de vegetação que pode ser preservada como mata ciliar e qual seria a efetiva influência desta para a redução da produção de sedimento e o aumento da infiltração. Esta verificação foi conduzida com a aplicação do modelo SWAT à bacia do Rio Siriri (Sergipe), considerando como cenários, a condição de uso e cobertura do solo existente no ano 2005 (C1) uma faixa de mata ciliar, com 30 m largura para cada lado da margem, ao longo de todos os cursos de água e das nascentes (C2). Os resultados mostraram que houve o incremento da recarga para os aquíferos (cenários C1 para C2), redução do escoamento superficial que chega ao exutório da bacia e redução da carga de sedimento, porém com pequeno percentual

Análises preliminares da influência do uso da terra na qualidade da água na sub-bacia do rio Siriri/SE.

A bacia do rio Japaratuba no estado de Sergipe tem apresentado nos últimos anos um processo de alteração de usos da terra muito intenso, principalmente na sub-bacia de um dos seus principais afluentes, o rio Siriri, onde se observa uma transição abrupta de áreas de pastagem e matas para culturas agrícolas, principalmente cana-de-açúcar. Ademais, nesta subbacia há a presença de atividades industriais e aglomerados urbanos, potencializando mudanças nos aspectos relacionados à qualidade ambiental dos recursos hídricos locais. Este estudo apresenta uma análise preliminar da qualidade das águas no rio Siriri e busca contribuir com o processo de entendimento do estado ambiental detectado