Modulational instability of spatially broadband nonlinear optical pulses in four-state atomic systems

The modulational instability of broadband optical pulses in a four-state atomic system is investigated. In particular, starting from a recently derived generalized nonlinear Schr\"odinger equation, a wave-kinetic equation is derived. A comparison between coherent and random phase wave states is made. It is found that the spatial spectral broadening can contribute to the nonlinear stability of ultra-short optical pulses. In practical terms, this could be achieved by using random phase plate techniques.Comment: 9 pages, 3 figures, to appear in Phys. Rev.

Bartter Syndrome. A New Therapeutic Approach

A Síndrome de Bartter é uma tubulopatia hereditária perdedora de sal, rara (cerca de 1,2 novos casos por 100 000 nados vivos por ano1), caracterizada por alcalose metabólica, hipocaliémia, hiperreninémia e hiperaldosterolémia de gravidade variável. A indometacina e elevadas doses de potássio oral têm sido até hoje as estratégias terapêuticas usadas, com elevado risco de lesão gastrointestinal. Desde Abril de 2009, o aliscireno – inibidor da renina – tem sido utilizado em casos pontuais de Síndrome de Bartter no adulto, desconhecendo-se a sua utilização em Pediatria. Os autores apresentam o caso clínico de uma criança de oito anos com Síndrome de Bartter, medicada com cloreto de potássio e indometacina oral, a quem foi diagnosticada uma úlcera gástrica gigante. De modo a permitir a redução da quantidade de potássio administrado, optou-se por iniciar o aliscireno

Entanglement versus Quantum Discord in Two Coupled Double Quantum Dots

We study the dynamics of quantum correlations of two coupled double quantum dots containing two excess electrons. The dissipation is included through the contact with an oscillator bath. We solve the Redfield master equation in order to determine the dynamics of the quantum discord and the entanglement of formation. Based on our results, we find that the quantum discord is more resistant to dissipation than the entanglement of formation for such a system. We observe that this characteristic is related to whether the oscillator bath is common to both qubits or not and to the form of the interaction Hamiltonian. Moreover, our results show that the quantum discord might be finite even for higher temperatures in the asymptotic limit.Comment: 14 pages, 8 figures (new version is the final version to appear in NJP

Modelling the 3D Climate of Venus with OASIS

Flexible 3D models to explore the vast diversity of terrestrial planets and interpret observational data are still in their early stages. In this work, we present OASIS: a novel and flexible 3D virtual planet laboratory. With OASIS we envision a platform that couples self-consistently seven individual modules representing the main physical and chemical processes that shape planetary environments. Additionally, OASIS is capable of producing simulated spectra from different instruments and observational techniques. In this work we focus on the benchmark test of coupling four of the physical modules: fluid dynamics, radiation, turbulence and surface/soil. To test the OASIS platform, we produced 3D simulations of the Venus climate and its atmospheric circulation and study how the modeled atmosphere changes with various cloud covers, atmospheric heat capacity, and surface friction. 3D simulations of Venus are challenging because they require long integration times with a computationally expensive radiative transfer code. By comparing OASIS results with observational data, we verify that the new model is able to successfully simulate Venus. With simulated spectra produced directly from the 3D simulations, we explore the capabilities of future missions, like LUVOIR, to observe Venus analogs located at a distance of 10 pc. With OASIS, we have taken the first steps to build a sophisticated and very flexible platform capable of studying the environment of terrestrial planets, which will be an essential tool to characterize observed terrestrial planets and plan future observations.Comment: MNRAS published versio

Modelling competing risks in nephrology research: an example in peritoneal dialysis

BACKGROUND: Modelling competing risks is an essential issue in Nephrology Research. In peritoneal dialysis studies, sometimes inappropriate methods (i.e. Kaplan-Meier method) have been used to estimate probabilities for an event of interest in the presence of competing risks. In this situation a competing risk analysis should be preferable. The objectives of this study are to describe the bias resulting from the application of standard survival analysis to estimate peritonitis-free patient survival and to provide alternative statistical approaches taking competing risks into account. METHODS: The sample comprises patients included in a university hospital peritoneal dialysis program between October 1985 and June 2011 (n = 449). Cumulative incidence function and competing risk regression models based on cause-specific and subdistribution hazards were discussed. RESULTS: The probability of occurrence of the first peritonitis is wrongly overestimated using Kaplan-Meier method. The cause-specific hazard model showed that factors associated with shorter time to first peritonitis were age (>=55 years) and previous treatment (haemodialysis). Taking competing risks into account in the subdistribution hazard model, age remained significant while gender (female) but not previous treatment was identified as a factor associated with a higher probability of first peritonitis event. CONCLUSIONS: In the presence of competing risks outcomes, Kaplan-Meier estimates are biased as they overestimated the probability of the occurrence of an event of interest. Methods which take competing risks into account provide unbiased estimates of cumulative incidence for each specific outcome experienced by patients. Multivariable regression models such as those based on cause-specific hazard and on subdistribution hazard should be used in this competing risk setting

Wrist Ultrasound Analysis Of Patients With Early Rheumatoid Arthritis.

In the present study, we evaluated 42 wrists using the semi-quantitative scales power Doppler ultrasound (PDUS) and gray scale ultrasound (GSUS) with scores ranging from 0 to 3 and correlated the results with clinical, laboratory and radiographic data. Twenty-one patients (17 women and 4 men) with rheumatoid arthritis according to criteria of the American College of Rheumatology were enrolled in the study from September 2008 to July 2009 at Universidade Estadual de Campinas (UNICAMP). The average disease duration was 14 months. The patients were 66.6% Caucasians and 33.3% non-Caucasians, with a mean age of 42 and 41 years, respectively. A dorsal longitudinal scan was performed by ultrasound on the radiocarpal and midcarpal joints using GE LOGIQ XP-linear ultrasound and a high frequency (8-10 MHz) transducer. All patients were X-rayed, and the Larsen score was determined for the joints, with grades ranging from 0 to V. This study showed significant correlations between clinical, sonographic and laboratory data: GSUS and swollen right wrist (r = 0.546), GSUS of right wrist and swelling of left wrist (r = 0.511), PDUS of right wrist and pain in left wrist (r = 0.436), PDUS of right wrist and C-reactive protein (r = 0.466). Ultrasound can be considered a useful tool in the diagnosis of synovitis in early rheumatoid arthritis mainly when the anti-cyclic citrullinated peptide and rheumatoid factor are negative, and can lead to an early change in the therapeutic decision.4411-

Modeling and simulation of wetted porous thermal barriers operating under high temperature or high heat flux

Porous media with high water content can be successfully used as thermal barriers to operate under high exposure temperatures and/or high heat fluxes. Modeling and simulation of such systems presents difficulties and challenges, which are pointed and worked out in this work. Liquid water and water vapor transfers are considered, including the capillary effects for the liquid phase, as well as the air transfer inside the porous medium. Heat transfer model includes conduction, radiation, enthalpy convection, sensible heating and phase change. A realistic model is considered at the exposed boundary in what concerns mass transfer: the outflow mass transfer is dictated by the water effusion and not by the convection transfer mechanism between the exposed surface and the environment. A set of numerical aspects is detailed, concerning both the numerical modeling and the solution of the discretization equations, which are crucial to obtain successful simulations. Some illustrative results are presented, showing the potential of the wetted porous media when used as thermal barriers, as well as the capabilities of the presented physical and numerical models to deal with such systems.http://www.sciencedirect.com/science/article/B6V3H-4RKDHVC-2/1/633ef2cefc7a7e2178f1d59743e3d24