Hypoglossal schwannoma masquerading as a carotid body tumor.

Study Objective. To describe the clinical presentation, evaluation, and treatment of a hypoglossal schwannoma. Methods. We report an unusual case of a hypoglossal schwannoma presenting as a pulsatile level II neck mass at the bifurcation of the external and internal carotid arteries, mimicking a carotid body tumor. Radiologic findings are reviewed in detail. Results. A 59-year-old female presented to a tertiary care medical center with complaints of a pulsatile right-sided neck mass. An MRA of the neck was obtained demonstrating a 5 cm mass located at the carotid artery bifurcation and causing splaying of the internal and external carotids. Based on clinical presentation and imaging, a diagnosis of a carotid body tumor was conferred and the patient scheduled for excision. Intraoperatively, the mass was noted to arise from the hypoglossal nerve, remaining independent of the carotid artery. On histopathologic analysis, the mass was determined to be consistent with hypoglossal schwannoma. Conclusion. Though rare, the hypoglossal schwannoma should remain a consideration in the evaluation of a parapharyngeal space mass. As this report demonstrates, the clinical and radiologic presentation of a hypoglossal schwannoma may closely mimic that of the more common carotid body tumor

Milk of calcium renal disease

No Abstract

OncoLog Volume 44, Number 12, December 1999

Collaboration Between Scientists, Clinicians Moves Apoptosis Studies Forward Answering the Who, What, and How of Medical Physics USHERING IN NEW TECHNOLOGIES: Medical Physicists Focus on IMRT, Ultrasound-Guided Brachytherapy DiaLog: Building Better Patient Care on the Foundation of Scientific Research, by John Mendelsohn, MD, President, Professor of Clinical Investigation House Call: Make Cancer Prevention Part of Your New Year\u27s Resolutionshttps://openworks.mdanderson.org/oncolog/1080/thumbnail.jp

Praxis Origins

The co-founders of the writing center studies journal Praxis look back on the origins of the journal, the role it played in their early careers as writing center administrators, and the way they wanted it to shape theory/practice in the field. Today, Praxis continues to evolve in response to the vision its editors bring and the changes they see in our disciplinary landscape

Agents of Change: African American Contributions to Writing Centers

African Americans and their contributions to our field’s first pedagogical models and operational structures are absent from writing center histories. This archival research invokes their presence by recounting the stories of five African American innovators—Bess Bolden “B. B.” Walcott, Coragreene Johnstone, Anne Cooke, Hugh Gloster, and Percival Bertrand “Bert” Phillips—spanning four decades at three historically Black colleges and universities (HBCUs). Their stories invite an expansive understanding of writing center work, moving beyond a focus on traditional tutoring and strictly alphabetic literacies and into “strategic literacies”—the survival skills needed to stand up for oneself and one’s community in the face of dangerous times and violently racist places. The writing center leaders described here saw writing as a tool to be used in concert with embodied performances for expression and survival to advance struggles for labor equity, legal justice, and civil rights. This conception of writing center work springs from sites of research such as HBCU archives and popular Black press archives that are less often examined by dominant disciplinary histories. From those sites, a timeline of African American writing center administrators emerges that spurs further research of these under-studied figures, who together constitute a remarkable legacy. Keywords: writing center studies, historically Black colleges and universities, composition studies history, higher educatio

Developmental expression of retinoic acid receptors (RARs)

Here, I review the developmental expression features of genes encoding the retinoic acid receptors (RARs) and the 'retinoid X' or rexinoid receptors (RXRs). The first detailed expression studies were performed in the mouse over two decades ago, following the cloning of the murine Rar genes. These studies revealed complex expression features at all stages of post-implantation development, one receptor gene (Rara) showing widespread expression, the two others (Rarb and Rarg) with highly regionalized and/or cell type-specific expression in both neural and non-neural tissues. Rxr genes also have either widespread (Rxra, Rxrb), or highly-restricted (Rxrg) expression patterns. Studies performed in zebrafish and Xenopus demonstrated expression of Rar and Rxr genes (both maternal and zygotic), at early pre-gastrulation stages. The eventual characterization of specific enzymes involved in the synthesis of retinoic acid (retinol/retinaldehyde dehydrogenases), or the triggering of its catabolism (CYP26 cytochrome P450s), all of them showing differential expression patterns, led to a clearer understanding of the phenomenons regulated by retinoic acid signaling during development. Functional studies involving targeted gene disruptions in the mouse, and additional approaches such as dominant negative receptor expression in other models, have pinpointed the specific, versus partly redundant, roles of the RARs and RXRs in many developing organ systems. These pleiotropic roles are summarized hereafter in relationship to the receptors’ expression patterns

Hypoglossal Schwannoma Masquerading as a Carotid Body Tumor

Study Objective. To describe the clinical presentation, evaluation, and treatment of a hypoglossal schwannoma. Methods. We report an unusual case of a hypoglossal schwannoma presenting as a pulsatile level II neck mass at the bifurcation of the external and internal carotid arteries, mimicking a carotid body tumor. Radiologic findings are reviewed in detail. Results. A 59-year-old female presented to a tertiary care medical center with complaints of a pulsatile right-sided neck mass. An MRA of the neck was obtained demonstrating a 5 cm mass located at the carotid artery bifurcation and causing splaying of the internal and external carotids. Based on clinical presentation and imaging, a diagnosis of a carotid body tumor was conferred and the patient scheduled for excision. Intraoperatively, the mass was noted to arise from the hypoglossal nerve, remaining independent of the carotid artery. On histopathologic analysis, the mass was determined to be consistent with hypoglossal schwannoma. Conclusion. Though rare, the hypoglossal schwannoma should remain a consideration in the evaluation of a parapharyngeal space mass. As this report demonstrates, the clinical and radiologic presentation of a hypoglossal schwannoma may closely mimic that of the more common carotid body tumor