34 research outputs found
Susceptibilidade antimicrobiana de cepas de estafilococcos coagulase-negativa isolados de ovinos de corte com mastite
Avaliou-se a sensibilidade antimicrobiana in vitro de 121 cepas de estafilococos coagulase-negativa isolada de leite de ovelhas Santa InĂȘs, aos fĂĄrmacos: penicilina, amoxicilina, ampicilina, estreptomicina, oxaciclina, neomicina, cefalotina, gentamicina e sulfonamida. A resistĂȘncia Ă sulfonamida foi a mais frequente (27,3%), seguida pela estreptomicina (14,0%) e pela oxaciclina (14,0%), enquanto da gentamicina (1,6%) foi a menos frequente. Todas as cepas foram sensĂveis a pelo menos um antimicrobiano, e 20,3% das cepas apresentaram resistĂȘncia mĂșltipla. Os resultados mostram a importĂąncia de Staphylococci coagulase-negativas como agentes causadores de mastite em ovinos, e o perfil de resistĂȘncia mĂșltipla indica a importĂąncia da determinação da resistĂȘncia Ă oxaciclina como indicador da presença de ilhas de patogenicidade que contĂȘm fatores de virulĂȘncia e resistĂȘncia a outros antimicrobianos que contribuem para a sobrevivĂȘncia da bactĂ©ria ao tratamento.Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP
Magnetic Field Amplification in Galaxy Clusters and its Simulation
We review the present theoretical and numerical understanding of magnetic
field amplification in cosmic large-scale structure, on length scales of galaxy
clusters and beyond. Structure formation drives compression and turbulence,
which amplify tiny magnetic seed fields to the microGauss values that are
observed in the intracluster medium. This process is intimately connected to
the properties of turbulence and the microphysics of the intra-cluster medium.
Additional roles are played by merger induced shocks that sweep through the
intra-cluster medium and motions induced by sloshing cool cores. The accurate
simulation of magnetic field amplification in clusters still poses a serious
challenge for simulations of cosmological structure formation. We review the
current literature on cosmological simulations that include magnetic fields and
outline theoretical as well as numerical challenges.Comment: 60 pages, 19 Figure
Antimicrobial susceptibility of coagulase-negative staphylococci isolated from meat-producing ewes with mastitis
Microbiological analysis and sensitivity profile of Staphylococcus spp. in subclinical mastitis of dairy goats
Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7Ă10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4Ă10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4Ă10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat
Deformation of Unstructured Viscous Grids
A mesh deformation algorithm for unstructured grids is presented. It is designed for high Reynolds number flow problems. Such grids are employed in aerodynamic and aeroelastic studies of wings or complete aircraft configurations in flows where the viscous effects are important. Given a surface deformation, the method efficiently recalculates new locations of high aspect ratio cells that make up the viscous layers of the grid and then deforms the inviscid part of the grid using an established method based on a torsional spring analogy technique. Results are presented for monitoring the deterioration of the quality of the grid during subsequent deformation steps for aeroelastic studies as well as to ensure the time efficiency of the method. Results for grid deformation of a 1.4 million cell AGARD 445.6 wing grid designed for flow at high Reynolds numbers due to typical deformations are also presented. Finally, a discussion of the parallelization performance and comparison of the running time of the mesh deformation algorithm to that used by the flow solver is made
Microbiological analysis and sensitivity profile of Staphylococcus spp. in subclinical mastitis of dairy goats
Subclinical mastitis in goats causes economic losses and risks to public health. Given the need for research that shows the most isolated staphylococci species and sensibility tests comparing the resistance between coagulase-negative (CNS) and positive Staphylococcus (CPS) goats with subclinical mastitis, the aim of this study was to identify the microorganisms isolated from milk samples of goats with subclinical mastitis, as well as define the staphylococci species and determine the sensitivity profile of Staphylococcus spp. to antimicrobials. To collect samples, tests were performed for mug of black background and California mastitis test (CMT), collecting milk from CMT positive animals. A total of 226 samples from seven herds of dairy goats was collected and forwarded to the laboratory, where they were seeded for the isolation of the microorganism and implementing the antibiotic sensibility test. Of these, 122 samples had bacterial growth and the most isolated staphylococci species were: S. epidermidis (24.55%), S. lugdunensis (15.40%) and S. intermedius (13.64%). Samples showed increased resistance to antimicrobials: penicillin (81.8%), oxacillin (60.0%) and ampicillin (55.5%). Greater sensitivity to: enrofloxacin (99.1%), erythromycin (98.2%), gentamicin (98.2%) and vancomycin (98.2%) were observed. The S. epidermidis showed higher antimicrobial resistance to amoxicillin and penicillin than S. lugdunensis and S. intermedius. Similar resistance in vitro between CNS and CPS was observed to most antimicrobials. It is important to control the overuse of antibiotics to prevent the emergence of resistant strains
Lactation stage and udder health status of Santa Ines ewes
Avaliou-se o risco de infecção em diferentes fases da lactação em 33 ovelhas da raça Santa InĂȘs. Inicialmente a glĂąndula foi submetida ao exame fĂsico e Ă prova de fundo escuro. Posteriormente, amostras de leite foram coletadas assepticamente para a realização de exame bacteriolĂłgico - California Mastitis teste -, e contagens microscĂłpica e automĂĄtica de cĂ©lulas somĂĄticas. Nenhuma diferença foi observada entre as distintas fases de lactação. Observou-se alta persistĂȘncia de infecçÔes intramamĂĄrias, e tendĂȘncia a maior contagem de cĂ©lulas somĂĄticas no Ășltimo perĂodo de lactação, que pode ser oriunda da maior resistĂȘncia a infecçÔes neste perĂodo