Hybrid method for selection of the optimal process of leachate treatment in waste treatment and valorization plants or landfills

“The final publication is available at Springer via http://dx.doi.org/10.1007/s10098-014-0834-4”Leachate from waste landfill or treatment plants is a very complex and highly contaminated liquid effluent. In its composition, it is found dissolved organic matter, inorganic salts, heavy metals, and other xenobiotic organic compounds, so it can be toxic, carcinogenic, and capable of inducing a potential risk to biota and humans. European law does not allow such leachate to leave the premises without being depolluted. There are many procedures that enable debugging, always combining different techniques. Choosing the best method to use in each case is a complex decision, as it depends on many tangible and intangible factors that must be weighed to achieve a balance between technical, cost, and environmental sustainability. It is presenting a hybrid method for choosing the optimal combination of techniques to apply in each case, by combining a multicriteria hierarchical analysis based on expert data obtained by the Delphi method with an analysis by the method of VIKOR to reach a consensus solution.Martín Utrillas, MG.; Reyes Medina, M.; Curiel Esparza, J.; Cantó Perelló, J. (2015). Hybrid method for selection of the optimal process of leachate treatment in waste treatment and valorization plants or landfills. Clean Technologies and Environmental Policy. 17(4):873-885. doi:10.1007/s10098-014-0834-4S873885174Abbas AA, Guo J, Ping LZ, Ya PY, Al-Rekabi WS (2009) Review on landfill leachate treatments. AJAS 6(4):672–684Abood AR, Bao J, Abudi Z, Zheng D, Gao C (2013) Pretreatment of nonbiodegradable landfill leachate by air stripping coupled with agitation as ammonia stripping and coagulation–flocculation processes. Clean Technol Environ Policy 15(6):1069–1076Ahn WY, Kang MS, Yim SK, Choi KH (2002) Advanced landfill leachate treatment using an integrated membrane process. Desalination 149(1–3):109–114Al-Subhi Al-Harbi KM (2001) Application of the AHP in project management. Int J Proj Manag 19:19–27Bernasconi M, Choirat C, Seri R (2014) Empirical properties of group preference aggregation methods employed in AHP: theory and evidence. Eur J Oper Res 232(3):584–592Boopathy R, Karthikeyan S, Mandal AB, Sekaran G (2013) Characterization and recovery of sodium chloride from salt-laden solid waste generated from leather industry. Clean Technol Environ Policy 15(1):117–124Brechet T, Tulkens H (2009) Beyond BAT: selecting optimal combinations of available techniques, with an example from the limestone industry. J Environ Manag 90:1790–1801Canto-Perello J, Curiel-Esparza J, Calvo V (2013) Criticality and threat analysis on utility tunnels for planning security policies of utilities in urban underground space. Expert Syst Appl 40(11):4707–4714Chen Y, Liu C, Nie J, Wu S, Wang D (2014) Removal of COD and decolorizing from landfill leachate by Fenton’s reagent advanced oxidation. Clean Technol Environ Policy 16(1):189–193Chiochetta CG, Goetten LC, Almeida SM, Quaranta G, Cotelle S, Radetski CM (2014) Leachates from solid wastes: chemical and eco(geno)toxicological differences between leachates obtained from fresh and stabilized industrial organic sludge. Environ Sci Pollut R 21:1090–1098Chiumenti A, da Borso F, Chiumenti R, Teri F, Segantin P (2013) Treatment of digestate from a co-digestion biogas plant by means of vacuum evaporation: tests for process optimization and environmental sustainability. Waste Manag 33(6):1339–1344Council Directive 1999/31/EC (1999) April 26th 1999, on the landfill of waste. European Union Council, Official Journal L 182, 16/07/1999 P. 0001–0019Curiel-Esparza J, Canto-Perello J (2012) Understanding the major drivers for implementation of municipal sustainable policies in underground space. Int J Sust Dev World 19(6):506–514Curiel-Esparza J, Canto-Perello J (2013) Selecting utilities placement techniques in urban underground engineering. Arch Civ Mech Eng 13(2):276–285Curiel-Esparza J, Canto-Perello J, Calvo MA (2004) Establishing sustainable strategies in urban underground engineering. Sci Eng Ethics 10(3):523–530Dong Y, Zhang G, Hong WC, Xu Y (2010) Consensus models for AHP group decision making under row geometric mean prioritization method. Decis Support Syst 49:281–289Duckstein L, Opricovic S (1980) Multiobjective Optimization in River Basin Development. Water Resour Res 16(1):14–20Ersahin ME, Ozgun H, van Lier JB (2013) Effect of support material properties on dynamic membrane filtration performance. Separ Sci Technol 48(15):2263–2269Gracht HA (2012) Consensus measurement in Delphi studies, review and implications for future quality assurance. Forecast Soc Chang 79(8):1525–1536Grisey E, Laffray X, Contoz O, Cavalli E, Mudry J, Aleya L (2012) The bioaccumulation performance of reeds and cattails in a constructed treatment wetland for removal of heavy metals in landfill leachate treatment (Etueffont, France). Water Air Soil Pollut 223:1723–1741Guoliang Z, Lei Q, Qin M, Zheng F, Dexin W (2013) Aerobic SMBR/reverse osmosis system enhanced by Fenton oxidation for advanced treatment of old municipal landfill leachate. Bioresour Technol 142:261–268Gupta SK, Singh G (2007) Assessment of the Efficiency and Economic Viability of Various Methods of Treatment of Sanitary Landfill Leachate. Environ Monit Assess 135:107–117Heyer KU, Stegmann R (2005) Landfill systems, sanitary landfilling of solid wastes, and long-term problems with leachate. In: Jördening HJ, Winter J (eds) Environmental Biotechnology. Wiley-VCH, Weinheim, p 375Hsu CC, Sandord BA (2007) The Delphi technique: making sense of consensus. PARE 12(10):1–7Kjeldsen P, Barlaz MA, Rooker AP, Baun A, Ledin A, Christensen TH (2002) Present and long-term composition of MSW landfill leachate: a review. Crit Rev Environ Sci Technol 32(4):297–336Lee WS (2013) Merger and acquisition evaluation and decision making model. Serv Ind J 33(15–16):1473–1494Lee GKL, Chan EHW (2008) The analytic hierarchy process (AHP) approach for assessment of urban renewal proposals. Soc Indic Res 89(1):155–168Li G, Wang W, Du Q (2010) Applicability of nanofiltration for the advanced treatment of landfill leachate. J Appl Polym Sci 116(4):2343–2347Mela K, Tiainen T, Heinisuo M (2012) Comparative study of multiple criteria decision making methods for building design. Adv Eng Inform 26:716–726Ozdemir MS, Saaty TL (2006) The unknown in decision making, what to do about it. Eur J Oper Res 174(1):349–359Renou S, Givaudan JG, Poulain S, Dirassouyan F, Moulin P (2008) Landfill leachate treatment: review and opportunity. J Hazard Mater 150(3):468–493Ritzkowski M, Stegmann R (2012) Landfill aeration worldwide: concepts, indications and findings. Waste Manag 32(7):1411–1419Romero C, Ramos P, Costa C, Marquez MC (2013) Raw and digested municipal waste compost leachate as potential fertilizer: comparison with a commercial fertilizer. J Clean Prod 59:73–78Roubelat F (2011) The Delphi method as a ritual: inquiring the Delphi Oracle. Forecast Soc Chang 78(9):1491–1499Saaty TL (1980) The analytic hierarchy process. Mc Graw-Hill, New YorkSaaty TL (2001) Decision making with dependence and feedback: the analytic network process, 2nd edn. RWS Publications, PittsburghSaaty TL (2008) Decision making with the analytic hierarchy process. Int J Serv Sci 1(1):83–98Saaty TL (2012) Decision making for leaders. The analytic hierarchy process for decisions in a complex world, 3rd edn. RWS Publications, PittsburghSan Cristobal J (2012) Contractor selection using multicriteria decision-making methods. J Constr Eng M 138(6):751–758Sayadi MK, Heydari M, Shahanaghi K (2009) Extension of VIKOR method for decision making problem with interval numbers. Appl Math Model 33:2257–2262Statnikova RB, Bordetskya A, Statnikov A (2005) Multi-criteria analysis of real-life engineering optimization problems: statement and solution. Nonlinear Anal 63:685–696Syamsuddin J (2010) The use of AHP in security policy decision making: an open office calc application. JSW 5(10):1162–1169Thapa RB, Murayama Y (2010) Drivers of urban growth in the Kathmandu valley, Nepal: examining the efficacy of the analytic hierarchy process. App Geogr 30(1):70–83van Praagh M, Heerenklage J, Smidt E, Modin H, Stegmann R, Persson KM (2009) Potential emissions from two mechanically–biologically pretreated (MBT) wastes. Waste Manag 29(2):859–868Vedaraman N, Shamshath BS, Srinivasan SV (2013) Response surface methodology for decolourisation of leather dye using ozonation in a packed bed reactor. Clean Technol Environ Policy 15(4):607–616Wang Q, Matsufuji Y, Dong L, Huang Q, Hirano F, Tanaka A (2006) Research on leachate recirculation from different types of landfills. Waste Manag 26:815–824Xing W, Lu W, Zhao Y (2013) Environmental impact assessment of leachate recirculation in landfill of municipal solid waste by comparing with evaporation and discharge (EASEWASTE). Waste Manag 33(2):382–389Yang W, Zhang KN, Chen YG, Zhou XZ, Jin FX (2013) Prediction on contaminant migration in aquifer of fractured granite substrata of landfill. J Cent South Univ 20(11):3193–3201Zavadskas EK, Turskis Z, Tamosaitiene J (2011) Selection of construction enterprises management strategy based on SWOT and multi-criteria analysis. ACME 11(4):1063–108

Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice

Background: Alzheimer’s disease (AD) brain shows an ongoing inflammatory condition and non-steroidal antiinflammatories diminish the risk of suffering the neurologic disease. Cannabinoids are neuroprotective and antiinflammatory agents with therapeutic potential. Methods: We have studied the effects of prolonged oral administration of transgenic amyloid precursor protein (APP) mice with two pharmacologically different cannabinoids (WIN 55,212-2 and JWH-133, 0.2 mg/kg/day in the drinking water during 4 months) on inflammatory and cognitive parameters, and on 18F-fluoro-deoxyglucose (18FDG) uptake by positron emission tomography (PET). Results: Novel object recognition was significantly reduced in 11 month old Tg APP mice and 4 month administration of JWH was able to normalize this cognitive deficit, although WIN was ineffective. Wild type mice cognitive performance was unaltered by cannabinoid administration. Tg APP mice showed decreased 18FDG uptake in hippocampus and cortical regions, which was counteracted by oral JWH treatment. Hippocampal GFAP immunoreactivity and cortical protein expression was unaffected by genotype or treatment. In contrast, the density of Iba1 positive microglia was increased in Tg APP mice, and normalized following JWH chronic treatment. Both cannabinoids were effective at reducing the enhancement of COX-2 protein levels and TNF-a mRNA expression found in the AD model. Increased cortical b-amyloid (Ab) levels were significantly reduced in the mouse model by both cannabinoids. Noteworthy both cannabinoids enhanced Ab transport across choroid plexus cells in vitro. Conclusions: In summary we have shown that chronically administered cannabinoid showed marked beneficial effects concomitant with inflammation reduction and increased Ab clearanceThis work was supported by the Spanish Ministry of Science and Technology (SAF 2005-02845 to M.L.C). A.M.M-M. was recipient a fellowship from the Ministry of Education and Scienc

Cannabis-induced psychosis like experiences are associated with high schizotypy

Objective: Recent studies have suggested that cannabis use is a risk factor for developing schizophrenia. We tested the hypothesis that cannabis use increases the likelihood of psychosis-like experiences in non-clinical participants who scored highly on a measure of schizotypy. Method: The psychological effects of cannabis were assessed in 137 healthy individuals (76% female, mean age 22 years) using a newly developed questionnaire concerned with subjective experiences of the drug: the Cannabis Experiences Questionnaire. The questionnaire has three subscales: Pleasurable Experiences, Psychosis-Like Experiences and After-Effects. Respondents also completed the brief Schizotypal Personality Questionnaire. Results: Cannabis use was reported by 72% of the sample. Use per se was not significantly related to schizotypy. However, high scoring schizotypes were more likely to report both psychosis-like experiences and unpleasant after-effects associated with cannabis use. The pleasurable effects of cannabis use were not related to schizotypy score. Conclusion: High scoring schizotypes who use cannabis are more likely to experience psychosis-like phenomena at the time of use, and unpleasant after-effects. Our results are consistent with the hypothesis that cannabis use is a risk factor for full psychosis in this group. Copyright (c) 2006 S. Karger AG, Basel

ATP release via anion channels

ATP serves not only as an energy source for all cell types but as an ‘extracellular messenger-for autocrine and paracrine signalling. It is released from the cell via several different purinergic signal efflux pathways. ATP and its Mg2+ and/or H+ salts exist in anionic forms at physiological pH and may exit cells via some anion channel if the pore physically permits this. In this review we survey experimental data providing evidence for and against the release of ATP through anion channels. CFTR has long been considered a probable pathway for ATP release in airway epithelium and other types of cells expressing this protein, although non-CFTR ATP currents have also been observed. Volume-sensitive outwardly rectifying (VSOR) chloride channels are found in virtually all cell types and can physically accommodate or even permeate ATP4- in certain experimental conditions. However, pharmacological studies are controversial and argue against the actual involvement of the VSOR channel in significant release of ATP. A large-conductance anion channel whose open probability exhibits a bell-shaped voltage dependence is also ubiquitously expressed and represents a putative pathway for ATP release. This channel, called a maxi-anion channel, has a wide nanoscopic pore suitable for nucleotide transport and possesses an ATP-binding site in the middle of the pore lumen to facilitate the passage of the nucleotide. The maxi-anion channel conducts ATP and displays a pharmacological profile similar to that of ATP release in response to osmotic, ischemic, hypoxic and salt stresses. The relation of some other channels and transporters to the regulated release of ATP is also discussed

Elite squash players nutrition knowledge and influencing factors

Background There is a reported mismatch between macronutrient consumption and contemporary macronutrient guidelines in elite standard squash players. Suboptimal dietary practices could be due to a lack of nutrition knowledge among players. Subsequently, the purpose of this study was to assess the sports nutrition knowledge of elite squash players through the Nutrition for Sport Knowledge Questionnaire (NSKQ) and provide an indication of whether players require nutrition support to increase their nutrition knowledge. Methods This cross-sectional study assessed the nutrition knowledge of 77 elite squash players via the NSKQ over the period of June 2020 to August 2020. Results Players conveyed average nutrition knowledge with a mean NSKQ score of 48.78 ± 10.06 (56.07% ± 11.56%). There were no significant differences in NSKQ score between male and female players (p = .532). There was found to be a weak positive association between world ranking and NSKQ score (r = .208) and age and NSKQ score (r = .281). Players who had a relevant undergraduate degree (e.g. BSc Sport & Exercise Science) had significantly greater NSKQ score than players with no relevant qualifications (p = .022). Players who consulted a sports nutritionist to obtain their main source of nutrition information were shown to have significantly greater knowledge than those who acquired knowledge from a sports scientist (p = .01) or the internet / social media (p = .007). Conclusions Players should consult with a sports nutritionist to increase their sport nutrition knowledge. Future research should quantify the effectiveness of a nutritional education intervention at increasing nutrition knowledge in players

CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

We have recently identified 1,8-naphthyridin-2(1H)-one-3-carboxamide as a new scaffold very suitable for the development of new CB2 receptor potent and selective ligands. In this paper we describe a number of additional derivatives in which the same central scaffold has been variously functionalized in position 1 or 6. All new compounds showed high selectivity and affinity in the nanomolar range for the CB2 receptor. Furthermore, we found that their functional activity is controlled by the presence of the substituents at position C-6 of the naphthyridine scaffold. In fact, the introduction of substituents in this position determined a functionality switch from agonist to antagonists/inverse agonists. Finally, docking studies showed that the difference between the pharmacology of these ligands may be in the ability/inability to block the Toggle Switch W6.48(258) (χ1 g+ → trans) transition