LA AGENDA DE 2030 PARA EL DESARROLLO SOSTENIBLE: UN ANíLISES DE LAS BRECHAS ESTRUCTURALES DEL PROGRESO INFORMACIONAL EN AMÉRICA LATINA

Este ensaio refere-se í  discussão do diagnóstico de lacunas estruturais para a Desenvolvimento latino-americano e seu impacto no desenvolvimento informacional da região com base em o estudo apresentado pela Comissão Econômica para a América Latina e o Caribe - CEPAL no documento Horizons 2030: Igualdade no Centro de Desenvolvimento Sustentável. A análise é baseada nos Objetivos de Desenvolvimento Sustentável - ODS até 2030 proposto em 2015 pela Organização das Nações Unidas - ONU e também no conceitos relacionados ao tópico levantado por Fernando Calderón, Manuel Castells e Pekka Himanen.This essay refers to the discussion of the diagnosis of structural gaps for the Latin American development and its impact on informational development in the region based on the study presented by the Economic Commission for Latin America and the Caribbean - ECLAC in the Horizons 2030 document: Equality in the Center for Sustainable Development. The analysis is based on the Sustainable Development Goals - SDG by 2030 proposed in 2015 by the United Nations Organization - UN and also in theconcepts related to the topic raised by Fernando Calderón, Manuel Castells and Pekka Himanen.Este ensayo se refiere a la discusión del diagnóstico de las brechas estructurales para el desarrollo de América Latina y su impacto en desarrollo informacional en la región basado en el estudio presentado por la Comisión Económica para América Latina y el Caribe – CEPAL en el documento Horizontes 2030: La Igualdad en el Centro del Desarrollo Sostenible. El análisis es fundamentado en los Objetivos del Desarrollo Sostenible – ODS para 2030 propuestos en 2015 por las Organización de las Naciones Unidas – ONU y también en las conceptuaciones relacionadas con el tema planteadas por de Fernando Calderón, Manuel Castells y Pekka Himanen

PROPUESTA DE FORTALECIMIENTO INSTITUCIONAL CONTROL INTERNO – DISTRITO FEDERAL/BRASIL

This essay refers to the formulation of institutional strengthening proposal based on capacity deficits2 of the Comptroller-General - CGDF, the central control bodyInternal Government of the Federal District - GDF (Brazil). The topic is relevant in the technical, political and scientific perspective, context in which the Latin American Faculty of Social Sciences - FLACSO recently published the book Control of Public Policies: The Question of Transparency and Transparency in Question (Flacso, 2017d), which brings together a set of investigations about internal control in Argentina addressing: structure, general norms, actors, characteristics, roles and capacities, among others.Este ensayo se refiere a la formulación de propuesta de fortalecimiento institucional basada en los déficits de capacidad2 de la Contralorí­a-General – CGDF, el órgano central de control interno del Gobierno del Distrito Federal – GDF (Brasil). El tema es relevante en la perspectiva de técnica, polí­tica y cientí­fica, contexto en lo cual la Facultad Latinoamericana de Ciencias Sociales – FLACSO publicó recientemente el libro Control de Polí­ticas Públicas: La Cuestión de la Transparencia y la Transparencia en Cuestión (Flacso, 2017d), que congrega un conjunto de investigaciones acerca del control interno en Argentina abordando: estructura, normas generales, actores, caracterí­sticas, roles y capacidades, entre otros

Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines

Several therapeutic properties have been attributed to epigallocatechin gallate (EGCG), a phytopharmaceutical polyphenol with antioxidant and antiproliferative activity. EGCG is however very prone to oxidation in aqueous solutions which changes its bioactive properties. Its loading in nanoparticles has been proposed to reduce its degradation while increasing its in vivo efficacy. The aim of this study was to compare the antiproliferative effect of EGCG before and after its loading in solid lipid nanoparticles (SLNs), against five different cell lines (Caco-2, HepG2, MCF-7, SV-80 and Y-79). EGCG produced concentration- and time-dependent antiproliferative effect, with eficacy dependent on the cell line. The order of potency was: MCF-7?>?SV-80?>?HepG2?>?Y-79?>?Caco-2, for 24h exposure (MCF-7 IC50=58.60?±?3.29 µg/mL; Caco-2 IC50>500.00 µg/mL). To the best of our knowledge this is the first study reporting EGCG antiproliferative effect in SV-80 and Y-79 cells. DDAB-SLN physicochemical properties (size ?134nm; PI?0.179; ZP ?+28mV) were only slightly modified with EGCG loading (EGCG-DDAB-SLN: ?144nm; PI?0.160; ZP ?+26mV). EGCG loadingin SLN, only slightly increases the EGCG antiproliferative effect in MCF-7 and SV-80 cells. SLN exhibited intrinsic toxicity, attributed to the surfactant used in its production. From the obtained results, the biocompatibility of blank SLN must be also considered when testing the efficacy of loaded phytopharmaceutics.The financial support was received from Portuguese Science and Technology Foundation (FCT) under the project UID/AGR/04033/2019 (CITAB). FCT is also acknowledge for the grants SFRH/BD/80335/2011 (JF) and SFRH/BD/60640/2009 (TA).info:eu-repo/semantics/publishedVersio

LA EVOLUCIÓN DE LAS PERSPECTIVAS DE MEDICIÓN DE LA POBREZA

This essay refers to the measurement of poverty in the one-dimensional perspective, based on the income, and the conceptual developments that made possible the structuring of a look multidimensional interpretation of socioeconomic phenomena related to deprivation, mainly in the perspective proposed by Amartya Sen, the Approach of Capacities, split into the Human Development Index (HDI) and the Poverty Index Multidimensional (IPM).Este ensayo se refiere a medición de la pobreza en la perspectiva unidimensional, basada en el ingreso, y las evoluciones conceptuales que viabilizaron la estructuración de una mirada multidimensional de interpretación de los fenómenos socioeconómicos relacionados con la privación, principalmente en la perspectiva propuesta por Amartya Sen, el Enfoque de las Capacidades, desdoblado en el Índice de Desarrollo Humano (IDH) y en el Índice de Pobreza Multidimensional (IPM)

O BRASIL TEM JEITO? UMA ANÁLISE DE ESFORÇOS GOVERNAMENTAIS E EMPRESARIAIS NO USO DE COMPLIANCE COMO FERRAMENTA DE COMBATE A CORRUPÇÃO NO BRASIL

This article intends to analyze the studies on the implementation of compliance in Brazil and the fight against corruption. Joining a worldwide effort, the country has sought to create tools and a favorable scenario to inhibit illicit practices in Public Administration together with private.Este artigo visa uma reflexão sobre os estudos a respeito da implantação do compliance no Brasil buscando o combate a corrupção. Unindo-se a um esforço mundial, o paí­s tem procurado criar ferramentas e um cenário favorável para inibir práticas ilí­citas na Administração Pública em conjunto com a iniciativa privada

THE COMPANY INTEGRITY PROGRAM CONTRACTORS OF CONTRACT WITH THE FEDERAL DISTRICT: ANALYSIS IN THE LIGHT OF LAW 6.112 / 2018

O presente artigo teve como proposição relacionar as boas práticas do compliance com a Lei 6.112/2018 implantada no âmbito do Distrito Federal, expondo assim os possí­veis efeitos da respectiva lei na gestão pública e nas empresas que participam do processo licitatório. Neste contexto, foi necessário propor uma pesquisa explicativa para entender o contexto da lei e suas implicações com uma análise bibliográfica e documental.The purpose of this article was to relate the good practices of compliance to the Act 6.112/2018, implemented within the scope of the Federal District, exposing, therefore, the possible effects of this law on public management and on companies that participate in the bidding process. In this context, it was necessary to propose an explanatory research to understand the context of this law and its implications through a bibliographical and documentary analysis

An Alternative Yukawa Unified SUSY Scenario

Supersymmetric SO(10) Grand Unified Theories with Yukawa unification represent an appealing possibility for physics beyond the Standard Model. However Yukawa unification is made difficult by large threshold corrections to the bottom mass. Generally one is led to consider models where the sfermion masses are large in order to suppress these corrections. Here we present another possibility, in which the top and bottom GUT scale Yukawa couplings are equal to a component of the charged lepton Yukawa matrix at the GUT scale in a basis where this matrix is not diagonal. Physically, this weak eigenstate Yukawa unification scenario corresponds to the case where the charged leptons that are in the 16 of SO(10) containing the top and bottom quarks mix with their counterparts in another SO(10) multiplet. Diagonalizing the resulting Yukawa matrix introduces mixings in the neutrino sector. Specifically we find that for a large region of parameter space with relatively light sparticles, and which has not been ruled out by current LHC or other data, the mixing induced in the neutrino sector is such that $sin^2 2\Theta_{23} \approx 1$, in agreement with data. The phenomenological implications are analyzed in some detail.Comment: 32 pages, 22 Figure

Thermal stress induces glycolytic beige fat formation via a myogenic state.

Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue. However, the molecular mechanisms by which physiological or pathological cues evoke developmental plasticity remain incompletely understood. Here we report a type of beige adipocyte that has a critical role in chronic cold adaptation in the absence of β-adrenergic receptor signalling. This beige fat is distinct from conventional beige fat with respect to developmental origin and regulation, and displays enhanced glucose oxidation. We therefore refer to it as glycolytic beige fat. Mechanistically, we identify GA-binding protein α as a regulator of glycolytic beige adipocyte differentiation through a myogenic intermediate. Our study reveals a non-canonical adaptive mechanism by which thermal stress induces progenitor cell plasticity and recruits a distinct form of thermogenic cell that is required for energy homeostasis and survival