Histomorphometric analysis of the human internal thoracic artery and relationship with cardiovascular risk factors

In this study, we aimed at performing a histomorphometric analysis of human left internal thoracic artery (ITA) samples as well as at correlating the histomorphometric findings with the clinical profile, including risk factors and medication. Distal segments of ITA were obtained from 54 patients undergoing coronary artery bypass grafting. Histological observation was performed in paraffin-embedded transverse sections of ITA through four staining protocols: hematoxylin-eosin, van Gieson, Masson's trichrome and von Kossa. Morphometric analysis included the intimal width (IW), medial width (MW) and intima/media ratio (IMR). No overt atherosclerotic lesions were observed. Mild calcifications were observed across the vascular wall layers in almost all samples. Multivariable linear regression analysis showed associations between IW and IMR and the following clinical variables: age, gender, kidney function expressed as eGFR and myocardial infarction history. Age (odds ratio = 1.16, P = 0.004), female gender (odds ratio = 11.34, P = 0.011), eGFR (odds ratio = 1.03, P = 0.059) and myocardial infarction history (odds ratio = 4.81, P = 0.040) were identified as the main clinical predictors for intimal hyperplasia. Preatherosclerotic lesions in ITA samples from patients undergoing coronary revascularization were associated not only with classical cardiovascular risk factors such as age and gender, but also with other clinical variables, namely kidney function and myocardial infarction history.info:eu-repo/semantics/publishedVersio

A dynamic network DEA model for accounting and financial indicators: A case of efficiency in MENA banking

Middle East and North Africa (MENA) countries present a banking industry that is well-known for regulatory and cultural heterogeneity, besides ownership, origin, and type diversity. This paper explores these issues by developing a Dynamic Network DEA model in order to handle the underlying relationships among major accounting and financial indicators. Firstly, a relational model encompassing major profit sheet, balance sheet, and financial health indicators is presented under a dynamic network structure. Subsequently, the dynamic effect of carry-over indicators is incorporated into it so that efficiency scores can be properly computed for these three substructures. The impact of contextual variables related to bank ownership, its type, and whether or not it has undergone a previous merger and acquisition process is tested by means of a stochastic non-linear model solved by differential evolution, which combines bootstrapped Simplex, Tobit, Beta, and Simar and Wilson truncated regression results. The results reveal that bank type, origin, and ownership impact efficiency levels differently in terms of profit sheet, balance sheet, and financial health indicators, although the impact of culture and regulatory barriers seem to prevail at the country level

The impact of the climate crisis on gender inequality. Looking to the frontlines in search of priorities for policy

The climate crisis disproportionately impacts women and girls all over the world. To understand what the priorities in terms of policy are, an examination is conducted on the impacts taking place in South Asia (focusing on the countries of Bangladesh, India, and Pakistan), an area of the globe that is highly vulnerable to climate change and is characterized by having strong patriarchal values. Gender stereotypes and roles in the region heighten women and girls' vulnerability to climate impacts, both in general and in situations of crisis resulting from extreme weather events. Deepening the understanding of the climate crisis' impact on gender in South Asia, a region at the frontline of these effects, can assist in reaching a baseline understanding of the challenge from a global perspective. Methodologically, we reviewed an extensive body of literature, both specialty books and scientific articles, recent institutional reports as well as news or journalistic reports from reliable international press. In this research, the argument is made that today, climate action and urban development cannot be considered separately from women's rights. Extensive scientific data and research support the integration of a gender perspective in urban adaptation standard practices, and priorities in terms of policy to safeguard women and girls are identified accordingly. The allocation of half of climate funds, including those of loss and damage, directly to women or women-led organizations is identified as being particularly relevant. Bold and ambitious policymaking is urgently needed to build capacity to face the multiple crises unfolding

Silver adsorption on biochar produced from spent coffee grounds: validation by kinetic and isothermal modelling

This study investigates silver adsorption on biochar produced from pyrolysis of spent coffee grounds (SCGs). Biochars were produced from SCGs at temperatures between 500 and 1000 °C. SCG-derived biochars were then characterised by different analytical methods, such as Brunauer-Emmet-Teller (BET), Fourier transform infrared (FTIR), X-ray diffraction (XRD), and investigated for silver removal. The results revealed that the biochar produced at 500 °C offered a maximum surface area of 40.1 m2/g with a yield of 23.48% biochar and the highest silver adsorption capacity of 49.0 mg/g with 99.9% silver removal efficiency. The morphology of adsorbed silver on biochar was determined using scanning electron microscopy–energy-dispersive spectrometry (SEM–EDS), and XRD analyses, which showed an even distribution of silver on the biochar surface. Furthermore, X-ray photoelectron spectroscopy (XPS) confirmed that part of the silver ions was reduced to form metallic silver (Ag0)/silver nanoparticles (Ag NPs) during adsorption. The kinetics and isothermal evaluation suggested that silver adsorption was dominated by the pseudo-second-order model and Langmuir isotherm, which means that silver adsorption was mainly dominated by chemisorption and monolayer on biochar surface. Overall, this study suggests that 500 °C was the most feasible pyrolysis temperature to produce SCG-derived biochar with suitable physicochemical properties that can efficiently adsorb silver species from wastewater

A circular economy approach for phosphorus removal using algae biochar

In this study, a potential circular economy approach for macroalgae (Ulva ohnoi) was investigated considering the crucial stages of biorefinery. Important stages, such as drying of biomass, production of biochar (pyrolysis), and application of biochar for phosphorus removal were studied and reported. It is important to note that drying macroalgae biomass from an average wet basis moisture content of ca. 70–85% to a moisture content suitable for thermal conversion, ca. 10%, is a challenging task. The physicochemical properties of biomass as well as biochar were characterized and were correlated with their capacity to adsorb phosphorus (P). The initial thermal analysis of macroalgae biomass revealed that the major weight loss occurred between 150 and 550 °C. The kinetics of the pyrolysis process indicate the requirement of higher apparent activation energy in between 232 and 836 kJ mol−1. An increase in the pore diameter, surface area, and pore volume in the biochar was noticed when the temperature of the pyrolysis process was increased. The highest P adsorption (78 mg-P/ g biochar) during the batch experiments was noticed with biochar obtained at 700 °C and can be due to the availability of alkali and alkaline earth metals. The kinetic study for P adsorption was described well by a pseudo second-order model. Biochar produced from macroalgae biomass can be considered as environmentally beneficial and low-cost adsorbent for phosphorus recovery. The biochar after adsorption may be used in agriculture as a slow release fertiliser due to significant amount of brushite

Progesterone reduces erectile dysfunction in sleep-deprived spontaneously hypertensive rats

BACKGROUND: Paradoxical sleep deprivation (PSD) associated with cocaine has been shown to enhance genital reflexes (penile erection-PE and ejaculation-EJ) in Wistar rats. Since hypertension predisposes males to erectile dysfunction, the aim of the present study was to investigate the effects of PSD on genital reflexes in the spontaneously hypertensive rat (SHR) compared to the Wistar strain. We also extended our study to examine how PSD affect steroid hormone concentrations involved in genital events in both experimental models. METHODS: The first experiment investigated the effects of PSD on genital reflexes of Wistar and SHR rats challenged by saline and cocaine (n = 10/group). To further examine the impact of the PSD on concentrations of sexual hormones, we performed a hormonal analysis of testosterone and progesterone in the Wistar and in SHR strains. Since after PSD progesterone concentrations decreased in the SHR compared to the Wistar PSD group we extended our study by investigating whether progesterone (25 mg/kg or 50 mg/kg) or testosterone (0.5 mg/kg or 1.0 mg/kg) administration during PSD would have a facilitator effect on the occurrence of genital reflexes in this hypertensive strain. RESULTS: A 4-day period of PSD induced PE in 50% of the Wistar rats against 10% for the SHR. These genital reflexes was potentiated by cocaine in Wistar rats whereas this scenario did not promote significant enhancement in PE and EJ in hypertensive rats, and the percentage of SHR displaying genital reflexes still figured significantly lower than that of the Wistar strain. As for hormone concentrations, both sleep-deprived Wistar and SHR showed lower testosterone concentrations than their respective controls. Sleep deprivation promoted an increase in concentrations of progesterone in Wistar rats, whereas no significant alterations were found after PSD in the SHR strain, which did not present enhancement in erectile responses. In order to explore the role of progesterone in the occurrence of genital reflexes, SHR were treated daily during the sleep deprivation period with progesterone; after the administration of this hormone and challenge with cocaine, we observed a significant increase in erectile events compared with the vehicle PSD SHR+cocaine group. CONCLUSION: Our data showed that the low frequency of genital reflexes found in SHR sleep deprived rats may be attributed to the lower concentrations of progesterone in these rats, based on the observation that progesterone replacement increased genital reflexes in this strain

Dental caries in Uruguayan adults and elders: findings from the first Uruguayan National Oral Health Survey

This study aimed to assess dental caries status and associated factors in Uruguayan adults and elders using data from the first Uruguayan National Oral Health Survey. Data were representative of the country as a whole. Socio-demographic information was collected with a closed questionnaire. Dental caries was assessed by clinical examination using the DMFT index. The final sample consisted of 769 participants. Mean DMFT was 15.20 and 24.12 for the 35-44 and 65-74-year age groups, respectively. Mean number of decayed teeth was 1.70 in adults and 0.66 in elders. Multivariate analyses showed higher prevalence of dental caries associated with age 65-74 years, low socioeconomic status, use of public dental services, presence of gingivitis; for decayed teeth, age 35-44 years, low socioeconomic status, use of public dental services, infrequent tooth brushing, need for oral health care, and presence of root caries showed higher severity. Uruguayan adults and elders from disadvantaged backgrounds concentrated a heavier burden of dental caries