1,367 research outputs found
Stochastic Invariants for Probabilistic Termination
Termination is one of the basic liveness properties, and we study the
termination problem for probabilistic programs with real-valued variables.
Previous works focused on the qualitative problem that asks whether an input
program terminates with probability~1 (almost-sure termination). A powerful
approach for this qualitative problem is the notion of ranking supermartingales
with respect to a given set of invariants. The quantitative problem
(probabilistic termination) asks for bounds on the termination probability. A
fundamental and conceptual drawback of the existing approaches to address
probabilistic termination is that even though the supermartingales consider the
probabilistic behavior of the programs, the invariants are obtained completely
ignoring the probabilistic aspect.
In this work we address the probabilistic termination problem for
linear-arithmetic probabilistic programs with nondeterminism. We define the
notion of {\em stochastic invariants}, which are constraints along with a
probability bound that the constraints hold. We introduce a concept of {\em
repulsing supermartingales}. First, we show that repulsing supermartingales can
be used to obtain bounds on the probability of the stochastic invariants.
Second, we show the effectiveness of repulsing supermartingales in the
following three ways: (1)~With a combination of ranking and repulsing
supermartingales we can compute lower bounds on the probability of termination;
(2)~repulsing supermartingales provide witnesses for refutation of almost-sure
termination; and (3)~with a combination of ranking and repulsing
supermartingales we can establish persistence properties of probabilistic
programs.
We also present results on related computational problems and an experimental
evaluation of our approach on academic examples.Comment: Full version of a paper published at POPL 2017. 20 page
Strong, Weak and Branching Bisimulation for Transition Systems and Markov Reward Chains: A Unifying Matrix Approach
We first study labeled transition systems with explicit successful
termination. We establish the notions of strong, weak, and branching
bisimulation in terms of boolean matrix theory, introducing thus a novel and
powerful algebraic apparatus. Next we consider Markov reward chains which are
standardly presented in real matrix theory. By interpreting the obtained matrix
conditions for bisimulations in this setting, we automatically obtain the
definitions of strong, weak, and branching bisimulation for Markov reward
chains. The obtained strong and weak bisimulations are shown to coincide with
some existing notions, while the obtained branching bisimulation is new, but
its usefulness is questionable
Bioactivity of the Murex Homeopathic Remedy and of Extracts from an Australian Muricid Mollusc against Human Cancer Cells
Marine molluscs from the family Muricidae are the source of a homeopathic remedy Murex, which is used to treat a range of conditions, including cancer. The aim of this study was to evaluate the in vitro bioactivity of egg mass extracts of the Australian muricid Dicathais orbita, in comparison to the Murex remedy, against human carcinoma and lymphoma cells. Liquid chromatography coupled with mass spectrometry (LC-MS) was used to characterize the chemical composition of the extracts and homeopathic remedy, focusing on biologically active brominated indoles. The MTS (tetrazolium salt) colorimetric assay was used to determine effects on cell viability, while necrosis and apoptosis induction were investigated using flow cytometry (propidium iodide and Annexin-V staining, resp.). Cells were treated with varying concentrations (1–0.01 mg/mL) of crude and semi-purified extracts or preparations (dilute 1 M and concentrated 4 mg/mL) from the Murex remedy (4 h). The Murex remedy showed little biological activity against the majority of cell lines tested. In contrast, the D. orbita egg extracts significantly decreased cell viability in the majority of carcinoma cell lines. Flow cytometry revealed these extracts induce necrosis in HT29 colorectal cancer cells, whereas apoptosis was induced in Jurkat cells. These findings highlight the biomedical potential of Muricidae extracts in the development of a natural therapy for the treatment of neoplastic tumors and lymphomas
Value Iteration for Long-run Average Reward in Markov Decision Processes
Markov decision processes (MDPs) are standard models for probabilistic
systems with non-deterministic behaviours. Long-run average rewards provide a
mathematically elegant formalism for expressing long term performance. Value
iteration (VI) is one of the simplest and most efficient algorithmic approaches
to MDPs with other properties, such as reachability objectives. Unfortunately,
a naive extension of VI does not work for MDPs with long-run average rewards,
as there is no known stopping criterion. In this work our contributions are
threefold. (1) We refute a conjecture related to stopping criteria for MDPs
with long-run average rewards. (2) We present two practical algorithms for MDPs
with long-run average rewards based on VI. First, we show that a combination of
applying VI locally for each maximal end-component (MEC) and VI for
reachability objectives can provide approximation guarantees. Second, extending
the above approach with a simulation-guided on-demand variant of VI, we present
an anytime algorithm that is able to deal with very large models. (3) Finally,
we present experimental results showing that our methods significantly
outperform the standard approaches on several benchmarks
On the relation between Differential Privacy and Quantitative Information Flow
Differential privacy is a notion that has emerged in the community of
statistical databases, as a response to the problem of protecting the privacy
of the database's participants when performing statistical queries. The idea is
that a randomized query satisfies differential privacy if the likelihood of
obtaining a certain answer for a database is not too different from the
likelihood of obtaining the same answer on adjacent databases, i.e. databases
which differ from for only one individual. Information flow is an area of
Security concerned with the problem of controlling the leakage of confidential
information in programs and protocols. Nowadays, one of the most established
approaches to quantify and to reason about leakage is based on the R\'enyi min
entropy version of information theory. In this paper, we analyze critically the
notion of differential privacy in light of the conceptual framework provided by
the R\'enyi min information theory. We show that there is a close relation
between differential privacy and leakage, due to the graph symmetries induced
by the adjacency relation. Furthermore, we consider the utility of the
randomized answer, which measures its expected degree of accuracy. We focus on
certain kinds of utility functions called "binary", which have a close
correspondence with the R\'enyi min mutual information. Again, it turns out
that there can be a tight correspondence between differential privacy and
utility, depending on the symmetries induced by the adjacency relation and by
the query. Depending on these symmetries we can also build an optimal-utility
randomization mechanism while preserving the required level of differential
privacy. Our main contribution is a study of the kind of structures that can be
induced by the adjacency relation and the query, and how to use them to derive
bounds on the leakage and achieve the optimal utility
Direct optical probe of magnon topology in two-dimensional quantum magnets
Controlling edge states of topological magnon insulators is a promising route to stable spintronics devices. However, to experimentally ascertain the topology of magnon bands is a challenging task. Here we derive a fundamental relation between the light-matter coupling and the quantum geometry of magnon states. This allows to establish the two-magnon Raman circular dichroism as an optical probe of magnon topology in honeycomb magnets, in particular of the Chern number and the topological gap. Our results pave the way for interfacing light and topological magnons in functional quantum devices
Completely positive maps with memory
The prevailing description for dissipative quantum dynamics is given by the
Lindblad form of a Markovian master equation, used under the assumption that
memory effects are negligible. However, in certain physical situations, the
master equation is essentially of a non-Markovian nature. This paper examines
master equations that possess a memory kernel, leading to a replacement of
white noise by colored noise. The conditions under which this leads to a
completely positive, trace-preserving map are discussed for an exponential
memory kernel. A physical model that possesses such an exponential memory
kernel is presented. This model contains a classical, fluctuating environment
based on random telegraph signal stochastic variables.Comment: 4 page
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