Persistent fluctuations in stride intervals under fractal auditory stimulation

Copyright @ 2014 Marmelat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Stride sequences of healthy gait are characterized by persistent long-range correlations, which become anti-persistent in the presence of an isochronous metronome. The latter phenomenon is of particular interest because auditory cueing is generally considered to reduce stride variability and may hence be beneficial for stabilizing gait. Complex systems tend to match their correlation structure when synchronizing. In gait training, can one capitalize on this tendency by using a fractal metronome rather than an isochronous one? We examined whether auditory cues with fractal variations in inter-beat intervals yield similar fractal inter-stride interval variability as isochronous auditory cueing in two complementary experiments. In Experiment 1, participants walked on a treadmill while being paced by either an isochronous or a fractal metronome with different variation strengths between beats in order to test whether participants managed to synchronize with a fractal metronome and to determine the necessary amount of variability for participants to switch from anti-persistent to persistent inter-stride intervals. Participants did synchronize with the metronome despite its fractal randomness. The corresponding coefficient of variation of inter-beat intervals was fixed in Experiment 2, in which participants walked on a treadmill while being paced by non-isochronous metronomes with different scaling exponents. As expected, inter-stride intervals showed persistent correlations similar to self-paced walking only when cueing contained persistent correlations. Our results open up a new window to optimize rhythmic auditory cueing for gait stabilization by integrating fractal fluctuations in the inter-beat intervals.Commission of the European Community and the Netherlands Organisation for Scientific Research

Flying without fear: Shooting disturbance has little effect on site preferences in a conflict goose species

This is the final version. Available from Wiley via the DOI in this record. DATA AVAILABILITY STATEMENT: Data and R code are available via the Dryad Digital Repository: https://doi.org/10.5061/dryad.kwh70rzch (McIntosh et al., 2024).Human-modified landscapes have created opportunities for numerous taxa. Agricultural expansion has proven advantageous for several Arctic-breeding goose species, leading to increased abundance and intensified conflict with farmers. Shooting is frequently implemented as a mitigation strategy to control population and via scaring to alter the spatial distribution of conflict species. However, the efficacy of such regimes in manipulating the fear landscape is not always investigated. We developed resource selection functions using GPS-tracking data for Greenland barnacle geese (Branta leucopsis) wintering on Islay, Scotland to assess foraging site choice. We assessed overall foraging site preference and evaluated the influence of shooting management on foraging site selection of key habitats. Barnacle geese selected for improved grassland areas and the likelihood of utilisation varied between these fields according to field-specific management. Protected areas were strongly selected for along with newly reseeded grassland. Field-level exposure to shooting disturbance did not cause a notable change in site selection. Synthesis and Applications: Our results demonstrate the importance of providing refuges within managed agricultural landscapes to encourage site use and minimise conflict. We highlight how low-intensity shooting disturbance may be ineffective in altering winter habitat selection of high-value foraging sites (especially near roosts). If future management aimed to stimulate redistribution, higher intensity shooting disturbance along with the spatial and temporal coordination of shooting effort would likely be required to create a stronger perceived gradient of disturbance risk.Natural Environment Research Council (NERC)NatureScotWildfowl and Wetlands Trus

Modelling harvest of Greenland barnacle geese and its implications in mitigating human–wildlife conflict

This is the final version. Available from Wiley via the DOI in this record. Data availability statement. R code, data and metadata are available via the Dryad Digital Repository http://doi.org/10.5061/dryad.4tmpg4ffj (McIntosh et al., 2023).Arctic-breeding goose populations have increased in recent decades and their expansion into agricultural areas has caused increasing conflict with farmers due to the damage they cause. Lethal control and scaring are common management strategies of conflict mitigation. Management typically focuses on local/national scales, making addressing the impact of localised control on the wider population challenging, particularly when populations move over large areas and cross international borders. We construct an integrated population model (IPM) to assess the cumulative impact of all shooting harvest (hunting and derogation shooting) on the Greenland barnacle goose, Branta leucopsis. We use data from monitoring schemes throughout the migratory flyway and use population projections to evaluate the impact of potential future shooting strategies on abundance. Our model suggests flyway abundance has declined since its 2012 peak, consistent with an increase in harvest rate and low productivity. Harvest rate increase was most pronounced on Islay (rising from 2% to 7% from 2011 to 2017), suggesting this was a probable cause of flyway abundance decline. Islay abundance has declined since derogation shooting began in 2000, while abundance at other wintering sites has increased. This may indicate that declines in Islay abundance may be due to both shooting mortality and emigration from Islay. Should future flyway-level harvest rates increase, further declines in abundance could be expected, and are likely to be more pronounced if harvests are extended to the entire winter range. Conversely, should harvest rates decline, an increase in abundance is predicted. Projections can therefore be used to allocate flyway-level harvest rates to alleviate local pressure without hindering flyway-level management objectives. Synthesis and applications. Our findings demonstrate the impact of local harvests on global abundance, emphasising the importance of internationally coordinated monitoring and management strategies of migratory species. IPMs provide a framework for adaptation to incorporate additional data when they become available and enable comparisons of future harvest scenarios to inform management strategies throughout the flyway.NatureScotDepartment of Housing Local Government and Heritage, IrelandNatural Environment Research CouncilWildfowl and Wetlands Trus

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain

Opioids are first-line drugs for moderate to severe acute pain and cancer pain. However, these medications are associated with severe side effects, and whether they are efficacious in treatment of chronic nonmalignant pain remains controversial. Medications that act through alternative molecular mechanisms are critically needed. Antagonists of α9α10 nicotinic acetylcholine receptors (nAChRs) have been proposed as an important nonopioid mechanism based on studies demonstrating prevention of neuropathology after trauma-induced nerve injury. However, the key α9α10 ligands characterized to date are at least two orders of magnitude less potent on human vs. rodent nAChRs, limiting their translational application. Furthermore, an alternative proposal that these ligands achieve their beneficial effects by acting as agonists of GABA(B) receptors has caused confusion over whether blockade of α9α10 nAChRs is the fundamental underlying mechanism. To address these issues definitively, we developed RgIA4, a peptide that exhibits high potency for both human and rodent α9α10 nAChRs, and was at least 1,000-fold more selective for α9α10 nAChRs vs. all other molecular targets tested, including opioid and GABA(B) receptors. A daily s.c. dose of RgIA4 prevented chemotherapy-induced neuropathic pain in rats. In wild-type mice, oxaliplatin treatment produced cold allodynia that could be prevented by RgIA4. Additionally, in α9 KO mice, chemotherapy-induced development of cold allodynia was attenuated and the milder, temporary cold allodynia was not relieved by RgIA4. These findings establish blockade of α9-containing nAChRs as the basis for the efficacy of RgIA4, and that α9-containing nAChRs are a critical target for prevention of chronic cancer chemotherapy-induced neuropathic pain

Incidence of lead ingestion in managed goose populations and the efficacy of imposed restrictions on the use of lead shot

This is the final version. Available from Wiley via the DOI in this record. Data Availability Statement. R code, data and metadata used for this study are available at: https://github.com/LukeOzsanlav/Islay_LeadGeese.Lead is a toxic heavy metal that when ingested can cause death or sub-lethal fitness effects. Despite its toxicity, it is still widely used in recreational and management shooting globally. To reduce the impacts of lead on wildfowl, recent European Union legislation has banned the use of lead shot in and around wetlands from 2023. Understanding the effectiveness of such mitigation is vital to inform future policy. On Islay, Scotland, the licensed shooting of Barnacle Geese Branta leucopsis to reduce agricultural damage has adhered to the ban on use of lead shot over Ramsar-designated wetlands legislated in Scotland in 2004. On average 2380 lead cartridges were fired annually between 2005 and 2020 outside designated wetlands, where Barnacle Geese and other wildfowl forage. From faecal samples, it is possible to infer whether birds have ingested lead and are therefore potentially suffering from lead poisoning. After sampling faeces from Barnacle Geese (n = 193) and Greenland White-fronted Geese Anser albifrons flavirostris (n = 150) we found only four (1.2%) faecal samples with elevated lead levels that may be indicative of lead shot ingestion. Further post-mortem examinations (n = 102 Barnacle Geese only) and X-ray of live birds (n = 293) revealed similarly low levels of shot ingestion in both species (post-mortem < 4%, and X-ray < 2%), corroborating findings from faecal sample analysis. When subsequently accounting for limited shot retention time within individuals, the proportion of each population ingesting a single lead shot over a winter was estimated at a maximum of 9.4% (Barnacle Geese) and 16.8% (White-fronted Geese). We propose that high compliance with the ban on using lead shot over wetlands because of carefully controlled shooting management on Islay has led to relatively low instantaneous ingestion rates, probably resulting in minimal lead poisoning mortality. However, ingestion was not eliminated and the potential fitness effect of chronic lead poisoning in both goose populations therefore persists, although use of lead shot in organized shooting has subsequently been discontinued. Recent European Union bans on lead shot use over wetlands may reduce lead ingestion in waterfowl if compliance rates are high, but as foraging often occurs outside wetlands (as in this study), further restrictions including use on other key foraging sites may help to further mitigate the risk of lead poisoning in waterfowl.Natural Environment Research CouncilWildfowl and Wetlands TrustNatureSco

Spatially-resolved electronic and vibronic properties of single diamondoid molecules

Diamondoids are a unique form of carbon nanostructure best described as hydrogen-terminated diamond molecules. Their diamond-cage structures and tetrahedral sp3 hybrid bonding create new possibilities for tuning electronic band gaps, optical properties, thermal transport, and mechanical strength at the nanoscale. The recently-discovered higher diamondoids (each containing more than three diamond cells) have thus generated much excitement in regards to their potential versatility as nanoscale devices. Despite this excitement, however, very little is known about the properties of isolated diamondoids on metal surfaces, a very relevant system for molecular electronics. Here we report the first molecular scale study of individual tetramantane diamondoids on Au(111) using scanning tunneling microscopy and spectroscopy. We find that both the diamondoid electronic structure and electron-vibrational coupling exhibit unique spatial distributions characterized by pronounced line nodes across the molecular surfaces. Ab-initio pseudopotential density functional calculations reveal that the observed dominant electronic and vibronic properties of diamondoids are determined by surface hydrogen terminations, a feature having important implications for designing diamondoid-based molecular devices.Comment: 16 pages, 4 figures. to appear in Nature Material

Gravito-electromagnetic analogies

We reexamine and further develop different gravito-electromagnetic (GEM) analogies found in the literature, and clarify the connection between them. Special emphasis is placed in two exact physical analogies: the analogy based on inertial fields from the so-called "1+3 formalism", and the analogy based on tidal tensors. Both are reformulated, extended and generalized. We write in both formalisms the Maxwell and the full exact Einstein field equations with sources, plus the algebraic Bianchi identities, which are cast as the source-free equations for the gravitational field. New results within each approach are unveiled. The well known analogy between linearized gravity and electromagnetism in Lorentz frames is obtained as a limiting case of the exact ones. The formal analogies between the Maxwell and Weyl tensors are also discussed, and, together with insight from the other approaches, used to physically interpret gravitational radiation. The precise conditions under which a similarity between gravity and electromagnetism occurs are discussed, and we conclude by summarizing the main outcome of each approach.Comment: 60 pages, 2 figures. Improved version (compared to v2) with some re-write, notation improvements and a new figure that match the published version; expanded compared to the published version to include Secs. 2.3 and

How are podocytes affected in nail–patella syndrome?

Nail–patella syndrome is an autosomal-dominant hereditary disease named for dysplastic fingernails and toenails and hypoplastic or absent kneecaps evident in patients with the syndrome. Prognosis is determined by the nephropathy that develops in many such patients. Besides podocyte foot-process effacement, pathognomonic changes in the kidney comprise electron-lucent areas and fibrillar inclusions in the glomerular basement membrane. These characteristic symptoms are caused by mutations in the gene encoding the transcription factor LMX1B, a member of the LIM-homeodomain gene family. Comparable with the human syndrome, homozygous Lmx1b knockout mice lack patellae and suffer from severe podocyte damage. In contrast, however, podocin and the α3 and α4 chains of collagen IV are absent in the glomeruli of Lmx1b knockout mice. Further studies with podocyte-specific Lmx1b knockout mice have confirmed the importance of LMX1B in podocytes, as these mice apparently develop foot processes initially but lose them later on. We therefore conclude that LMX1B is essential for the development of metanephric precursor cells into podocytes and possibly also for maintaining the differentiation status of podocytes. LMX1B can serve as a model system to elucidate a genetic program in podocytes

Cost effectiveness of pediatric pneumococcal conjugate vaccines: a comparative assessment of decision-making tools

BACKGROUND: Several decision support tools have been developed to aid policymaking regarding the adoption of pneumococcal conjugate vaccine (PCV) into national pediatric immunization programs. The lack of critical appraisal of these tools makes it difficult for decision makers to understand and choose between them. With the aim to guide policymakers on their optimal use, we compared publicly available decision-making tools in relation to their methods, influential parameters and results. METHODS: The World Health Organization (WHO) requested access to several publicly available cost-effectiveness (CE) tools for PCV from both public and private provenance. All tools were critically assessed according to the WHO's guide for economic evaluations of immunization programs. Key attributes and characteristics were compared and a series of sensitivity analyses was performed to determine the main drivers of the results. The results were compared based on a standardized set of input parameters and assumptions. RESULTS: Three cost-effectiveness modeling tools were provided, including two cohort-based (Pan-American Health Organization (PAHO) ProVac Initiative TriVac, and PneumoADIP) and one population-based model (GlaxoSmithKline's SUPREMES). They all compared the introduction of PCV into national pediatric immunization program with no PCV use. The models were different in terms of model attributes, structure, and data requirement, but captured a similar range of diseases. Herd effects were estimated using different approaches in each model. The main driving parameters were vaccine efficacy against pneumococcal pneumonia, vaccine price, vaccine coverage, serotype coverage and disease burden. With a standardized set of input parameters developed for cohort modeling, TriVac and PneumoADIP produced similar incremental costs and health outcomes, and incremental cost-effectiveness ratios. CONCLUSIONS: Vaccine cost (dose price and number of doses), vaccine efficacy and epidemiology of critical endpoint (for example, incidence of pneumonia, distribution of serotypes causing pneumonia) were influential parameters in the models we compared. Understanding the differences and similarities of such CE tools through regular comparisons could render decision-making processes in different countries more efficient, as well as providing guiding information for further clinical and epidemiological research. A tool comparison exercise using standardized data sets can help model developers to be more transparent about their model structure and assumptions and provide analysts and decision makers with a more in-depth view behind the disease dynamics. Adherence to the WHO guide of economic evaluations of immunization programs may also facilitate this process. Please see related article: http://www.biomedcentral.com/1741-7007/9/55