Impact of a Geography-Literature Collaborative on Secondary School Pedagogy

Geography education has been relegated to a subset of social studies standards in most of the United States and has been overshadowed by a history-centered curriculum. Student achievement in geography has not improved for several decades due to the focus on history content in the social studies curriculum. Rooted in a conceptual framework encompassing elements of self-efficacy and the whole teacher approach, the purpose of this case study was to examine the impact of the West Virginia Geographic Alliance (WVGA) professional development workshop on teachers\u27 practices in delivering cross-disciplinary geography education. The research questions addressed teachers\u27 perceived self-efficacy in delivering cross-disciplinary geography and literature instruction and the long-term changes they made to their classroom pedagogy. Data collection involved open-ended, semistructured interviews with 6 teachers (3 geography and 3 literature) who attended the WVGA training. Analysis of interview transcripts with open and axial coding revealed that teachers perceived geography as an important discipline and an effective means of enhancing literature instruction. Perceived obstacles to cross-disciplinary geography instruction included rigid content standards, scheduling conflicts, and time constraints. Findings indicated that future geography professional development should be relevant to teachers\u27 needs and based on state standards for geography instruction. Findings may be used to promote cross-disciplinary geography instruction through professional development

Activity-promoting gaming systems in exercise and rehabilitation

Commercial activity-promoting gaming systems provide a potentially attractive means to facilitate exercise and rehabilitation. The Nintendo Wii, Sony EyeToy, Dance Dance Revolution, and Xbox Kinect are examples of gaming systems that use the movement of the player to control gameplay. Activity-promoting gaming systems can be used as a tool to increase activity levels in otherwise sedentary gamers and also be an effective tool to aid rehabilitation in clinical settings. Therefore, the aim of this current work is to review the growing area of activity-promoting gaming in the context of exercise, injury, and rehabilitation

Operative versus nonoperative treatment of acute Achilles tendon ruptures: A pilot economic decision analysis

Background: The operative treatment of Achilles tendon ruptures has been associated with lower rerupture rates and better function but also a risk of surgery-related complications compared with nonoperative treatment, which may provide improved outcomes with accelerated rehabilitation protocols. However, economic decision analyses integrating the updated costs of both treatment options are limited in the literature. Purpose: To compare the cost-effectiveness of operative and nonoperative treatment of acute Achilles tendon tears. Study Design: Economic and decision analysis; Level of evidence, 2. Methods: An economic decision model was built to assess the cost-utility ratio (CUR) of open primary repair versus nonoperative treatment for acute Achilles tendon ruptures, based on direct costs from the practices of sports medicine and foot and ankle surgeons at a single tertiary academic center, with published outcome probabilities and patient utility data. Multiway sensitivity analyses were performed to reflect the range of data. Results: Nonoperative treatment was more cost-effective in the average scenario (nonoperative CUR, US$520; operative CUR, US$1995), but crossover occurred during the sensitivity analysis (nonoperative CUR range, US$224-US$2079; operative CUR range, US$789-US$8380). Operative treatment cost an extra average marginal CUR of US$1475 compared with nonoperative treatment, assuming uneventful healing in both treatment arms. The sensitivity analysis demonstrated a decreased marginal CUR of operative treatment when the outcome utility was maximized, and rerupture rates were minimized compared with nonoperative treatment. Conclusion: Nonoperative treatment was more cost-effective in average scenarios. Crossover indicated that open primary repair would be favorable for maximized outcome utility, such as that for young athletes or heavy laborers. The treatment decision for acute Achilles tendon ruptures should be individualized. These pilot results provide inferences for further longitudinal analyses incorporating future clinical evidence

Drag Reduction of a Modern Straight Truck

A wind tunnel test program was conducted at the Langley Full Scale Tunnel (LFST) to evaluate the performance of five passive drag reduction configurations on a modern straight truck at full scale. Configurations were tested in a build-up fashion with results representing a cumulative effect. Tested configurations include a front valance, a front box fairing, a boat-tail, an ideal side-skirt, and a practical side-skirt. Configurations were evaluated over a nominal 9 degree yaw sweep to establish wind averaged drag coefficients using SAE J1252. Genuine replicate yaw sweeps were used in an uncertainty analysis. Results show up to 28% improvement in wind-averaged drag coefficient and that significant gains can be made in straight truck fuel economy, even at non-highway speeds. © 2011 SAE International

Study of picosecond-scale electron dynamics in laser-produced plasmas with and without an external magnetic field

textThe interaction of ultra-short laser pulses and cluster targets can be used to explore a number of interesting phenomena, ranging from nuclear fusion to astrophysical blast waves. In our experiments, we focused on exploring very fast plasma dynamics of a plasma created by ionizing clusters and monomer gas. By using a 115 fs laser pulse, we can even study sub-picosecond plasma dynamics. In addition, we also wanted to impose an external magnetic field on these plasmas to study how the plasma evolution would change. The results of this work produced two significant results. First, a new, extremely fast ionization mechanism, with velocities as high as 0.5 c, was discovered which allows for significant plasma expansion on a picosecond time-scale. Experimental studies measured the velocity of the ionization wave, while particle-in-cell simulations helped explain the source and longevity of the wave. It was also observed that this ionization wave was not affected by the external magnetic field. Second, the external field was shown to inhibit plasma expansion on a time-scale of tens of picoseconds, which seems to be one of the first demonstrations of magnetic confinement on such a fast time-scale. Simple 1D simulations tell us that the field appears to slow electron heat transport in the plasma as well as inhibiting collisional ionization of electrons expanding into the surrounding gas. The inhibition of plasma expansion by the field on this time-scale may provide some evidence that magnetic confinement of a fusion plasma created by exploding clusters could improve the fusion yield by slowing heat loss as well as possibly electrostatically confining the hot ions.Physic

Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection

SummaryThe neural correlates of optimal states for signal detection task performance are largely unknown. One hypothesis holds that optimal states exhibit tonically depolarized cortical neurons with enhanced spiking activity, such as occur during movement. We recorded membrane potentials of auditory cortical neurons in mice trained on a challenging tone-in-noise detection task while assessing arousal with simultaneous pupillometry and hippocampal recordings. Arousal measures accurately predicted multiple modes of membrane potential activity, including rhythmic slow oscillations at low arousal, stable hyperpolarization at intermediate arousal, and depolarization during phasic or tonic periods of hyper-arousal. Walking always occurred during hyper-arousal. Optimal signal detection behavior and sound-evoked responses, at both sub-threshold and spiking levels, occurred at intermediate arousal when pre-decision membrane potentials were stably hyperpolarized. These results reveal a cortical physiological signature of the classically observed inverted-U relationship between task performance and arousal and that optimal detection exhibits enhanced sensory-evoked responses and reduced background synaptic activity.Video Abstrac

Building Cultural Competency among Emerging Public Health Professionals: Student Experiences in Panama

One of the prerequisite skills of effective public health and health practitioners is cultural competency. Cultural competency, however, requires a deep and profound understanding of individuals who are shaped by different life experiences than one’s own. Previous authors have described study abroad and service-learning as established strategies for enhancing cultural competency among emerging health professionals. This article describes how students made meaning of an international study abroad experience in Panama through analysis of student-produced work including reflective journal entries, blog posts, and photo journaling. In summer 2019, 13 undergraduate and graduate students participated in a four-week travel course to explore the complex and interrelated concepts of population health, health equity, and social determinants of health. Through visits to clinics and health facilities as well as service-learning activities, students identified strengths and challenges to health and health care in Panama. Furthermore, interactions with health officials and community members encouraged students to challenge their own biases and assumptions, which is a first step towards developing cultural competency. Despite the short duration of this travel course, instructors used intentional pre-departure activities and readings as well as daily reflective essays to scaffold student learning. Moreover, reflective writing assignments provided students an outlet to record their observations of external expressions of culture (i.e., customs, rituals, styles) and internal expressions of culture (i.e., attitudes, habits, norms) and discuss their relevance in terms of health behaviors. This level of deep reflection compelled students to engage more fully in their own learning experience

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.

Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells. The persister cell pool constitutes a reservoir from which drug-resistant tumours may emerge. Targeting persister cells therefore presents a therapeutic opportunity to impede tumour relapse. We previously found that cancer cells in a high mesenchymal therapy-resistant cell state are dependent on the lipid hydroperoxidase GPX4 for survival. Here we show that a similar therapy-resistant cell state underlies the behaviour of persister cells derived from a wide range of cancers and drug treatments. Consequently, we demonstrate that persister cells acquire a dependency on GPX4. Loss of GPX4 function results in selective persister cell ferroptotic death in vitro and prevents tumour relapse in mice. These findings suggest that targeting of GPX4 may represent a therapeutic strategy to prevent acquired drug resistance