1,000 research outputs found
The Gauging of Five-dimensional, N=2 Maxwell-Einstein Supergravity Theories coupled to Tensor Multiplets
We study the general gaugings of N=2 Maxwell-Einstein supergravity theories
(MESGT) in five dimensions, extending and generalizing previous work. The
global symmetries of these theories are of the form SU(2)_R X G, where SU(2)_R
is the R-symmetry group of the N=2 Poincare superalgebra and G is the group of
isometries of the scalar manifold that extend to symmetries of the full action.
We first gauge a subgroup K of G by turning some of the vector fields into
gauge fields of K while dualizing the remaining vector fields into tensor
fields transforming in a non-trivial representation of K. Surprisingly, we find
that the presence of tensor fields transforming non-trivially under the
Yang-Mills gauge group leads to the introduction of a potential which does not
admit an AdS ground state. Next we give the simultaneous gauging of the U(1)_R
subgroup of SU(2)_R and a subgroup K of G in the presence of K-charged tensor
multiplets. The potential introduced by the simultaneous gauging is the sum of
the potentials introduced by gauging K and U(1)_R separately. We present a list
of possible gauge groups K and the corresponding representations of tensor
fields. For the exceptional supergravity we find that one can gauge the SO^*(6)
subgroup of the isometry group E_{6(-26)} of the scalar manifold if one
dualizes 12 of the vector fields to tensor fields just as in the gauged N=8
supergravity.Comment: Latex file, 23 page
Unified Maxwell-Einstein and Yang-Mills-Einstein Supergravity Theories in Five Dimensions
Unified N=2 Maxwell-Einstein supergravity theories (MESGTs) are supergravity
theories in which all the vector fields, including the graviphoton, transform
in an irreducible representation of a simple global symmetry group of the
Lagrangian. As was established long time ago, in five dimensions there exist
only four unified Maxwell-Einstein supergravity theories whose target manifolds
are symmetric spaces. These theories are defined by the four simple Euclidean
Jordan algebras of degree three. In this paper, we show that, in addition to
these four unified MESGTs with symmetric target spaces, there exist three
infinite families of unified MESGTs as well as another exceptional one. These
novel unified MESGTs are defined by non-compact (Minkowskian) Jordan algebras,
and their target spaces are in general neither symmetric nor homogeneous. The
members of one of these three infinite families can be gauged in such a way as
to obtain an infinite family of unified N=2 Yang-Mills-Einstein supergravity
theories, in which all vector fields transform in the adjoint representation of
a simple gauge group of the type SU(N,1). The corresponding gaugings in the
other two infinite families lead to Yang-Mills-Einstein supergravity theories
coupled to tensor multiplets.Comment: Latex 2e, 28 pages. v2: reference added, footnote 14 enlarge
Unified N=2 Maxwell-Einstein and Yang-Mills-Einstein Supergravity Theories in Four Dimensions
We study unified N=2 Maxwell-Einstein supergravity theories (MESGTs) and
unified Yang-Mills Einstein supergravity theories (YMESGTs) in four dimensions.
As their defining property, these theories admit the action of a global or
local symmetry group that is (i) simple, and (ii) acts irreducibly on all the
vector fields of the theory, including the ``graviphoton''. Restricting
ourselves to the theories that originate from five dimensions via dimensional
reduction, we find that the generic Jordan family of MESGTs with the scalar
manifolds [SU(1,1)/U(1)] X [SO(2,n)/SO(2)X SO(n)] are all unified in four
dimensions with the unifying global symmetry group SO(2,n). Of these theories
only one can be gauged so as to obtain a unified YMESGT with the gauge group
SO(2,1). Three of the four magical supergravity theories defined by simple
Euclidean Jordan algebras of degree 3 are unified MESGTs in four dimensions.
Two of these can furthermore be gauged so as to obtain 4D unified YMESGTs with
gauge groups SO(3,2) and SO(6,2), respectively. The generic non-Jordan family
and the theories whose scalar manifolds are homogeneous but not symmetric do
not lead to unified MESGTs in four dimensions. The three infinite families of
unified five-dimensional MESGTs defined by simple Lorentzian Jordan algebras,
whose scalar manifolds are non-homogeneous, do not lead directly to unified
MESGTs in four dimensions under dimensional reduction. However, since their
manifolds are non-homogeneous we are not able to completely rule out the
existence of symplectic sections in which these theories become unified in four
dimensions.Comment: 47 pages; latex fil
Exoplanets and SETI
The discovery of exoplanets has both focused and expanded the search for
extraterrestrial intelligence. The consideration of Earth as an exoplanet, the
knowledge of the orbital parameters of individual exoplanets, and our new
understanding of the prevalence of exoplanets throughout the galaxy have all
altered the search strategies of communication SETI efforts, by inspiring new
"Schelling points" (i.e. optimal search strategies for beacons). Future efforts
to characterize individual planets photometrically and spectroscopically, with
imaging and via transit, will also allow for searches for a variety of
technosignatures on their surfaces, in their atmospheres, and in orbit around
them. In the near-term, searches for new planetary systems might even turn up
free-floating megastructures.Comment: 9 page invited review. v2 adds some references and v3 has other minor
additions and modification
Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis.
Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously, no membrane protein was found so far. As there is a great overlap between glycoproteins and membrane proteins, the aim of this study was to test whether pre-enrichment of retinal glycoproteins by ConA affinity is an effective tool to detect autoantigen candidates among membrane proteins. In 1D Western blots, the glycoprotein preparation allowed detection of IgG reactions to low abundant proteins in sera of ERU patients. Synaptotagmin-1, a Ca2+-sensing protein in synaptic vesicles, was identified as autoantigen candidate from the pre-enriched glycoprotein fraction by mass spectrometry and was validated as a highly prevalent autoantigen by enzyme-linked immunosorbent assay. Analysis of Syt1 expression in retinas of ERU cases showed a downregulation in the majority of ERU affected retinas to 24%. Results pointed to a dysregulation of retinal neurotransmitter release in ERU. Identification of synaptotagmin-1, the first cell membrane associated autoantigen in this spontaneous autoimmune disease, demonstrated that examination of tissue fractions can lead to the discovery of previously undetected novel autoantigens. Further experiments will address its role in ERU pathology
SPECULOOS exoplanet search and its prototype on TRAPPIST
One of the most significant goals of modern science is establishing whether
life exists around other suns. The most direct path towards its achievement is
the detection and atmospheric characterization of terrestrial exoplanets with
potentially habitable surface conditions. The nearest ultracool dwarfs (UCDs),
i.e. very-low-mass stars and brown dwarfs with effective temperatures lower
than 2700 K, represent a unique opportunity to reach this goal within the next
decade. The potential of the transit method for detecting potentially habitable
Earth-sized planets around these objects is drastically increased compared to
Earth-Sun analogs. Furthermore, only a terrestrial planet transiting a nearby
UCD would be amenable for a thorough atmospheric characterization, including
the search for possible biosignatures, with near-future facilities such as the
James Webb Space Telescope. In this chapter, we first describe the physical
properties of UCDs as well as the unique potential they offer for the detection
of potentially habitable Earth-sized planets suitable for atmospheric
characterization. Then, we present the SPECULOOS ground-based transit survey,
that will search for Earth-sized planets transiting the nearest UCDs, as well
as its prototype survey on the TRAPPIST telescopes. We conclude by discussing
the prospects offered by the recent detection by this prototype survey of a
system of seven temperate Earth-sized planets transiting a nearby UCD,
TRAPPIST-1.Comment: Submitted as a chapter in the "Handbook of Exoplanets" (editors: H.
Deeg & J.A. Belmonte; Section Editor: N. Narita). 16 pages, 4 figure
COVID-19 and cancer registries: Learning from the first peak of the SARS-CoV-2 pandemic
The SARS-Cov-2 pandemic in 2020 has caused oncology teams around the world to adapt their practice in the aim of protecting patients. Early evidence from China indicated that patients with cancer, and particularly those who had recently received chemotherapy or surgery, were at increased risk of adverse outcomes following SARS-Cov-2 infection. Many registries of cancer patients infected with SARS-Cov-2 emerged during the first wave. We collate the evidence from these national and international studies and focus on the risk factors for patients with solid cancers and the contribution of systemic anti-cancer treatments (SACT-chemotherapy, immunotherapy, targeted and hormone therapy) to outcomes following SARS-Cov-2 infection. Patients with cancer infected with SARS-Cov-2 have a higher probability of death compared with patients without cancer. Common risk factors for mortality following COVID-19 include age, male sex, smoking history, number of comorbidities and poor performance status. Oncological features that may predict for worse outcomes include tumour stage, disease trajectory and lung cancer. Most studies did not identify an association between SACT and adverse outcomes. Recent data suggest that the timing of receipt of SACT may be associated with risk of mortality. Ongoing recruitment to these registries will enable us to provide evidence-based care
Global Chromatin Domain Organization of the Drosophila Genome
In eukaryotes, neighboring genes can be packaged together in specific chromatin structures that ensure their coordinated expression. Examples of such multi-gene chromatin domains are well-documented, but a global view of the chromatin organization of eukaryotic genomes is lacking. To systematically identify multi-gene chromatin domains, we constructed a compendium of genome-scale binding maps for a broad panel of chromatin-associated proteins in Drosophila melanogaster. Next, we computationally analyzed this compendium for evidence of multi-gene chromatin domains using a novel statistical segmentation algorithm. We find that at least 50% of all fly genes are organized into chromatin domains, which often consist of dozens of genes. The domains are characterized by various known and novel combinations of chromatin proteins. The genes in many of the domains are coregulated during development and tend to have similar biological functions. Furthermore, during evolution fewer chromosomal rearrangements occur inside chromatin domains than outside domains. Our results indicate that a substantial portion of the Drosophila genome is packaged into functionally coherent, multi-gene chromatin domains. This has broad mechanistic implications for gene regulation and genome evolution
Experimentally manipulated self-affirmation promotes reduced alcohol consumption in response to narrative information
Background: Health-risk information is increasingly being conveyed through accounts of personal experiences or narrative information. However, whether self-affirmation can enhance the ability of such messages to promote behavior change has yet to be established.
Purpose: This study aims to test whether self-affirmation (a) promotes behavior change following exposure to narrative information about the risks of excessive alcohol consumption and (b) boosts message acceptance by increasing narrative engagement.
Methods: In an experimental design, female drinkers (N = 142) reported their baseline alcohol consumption and were randomly allocated to condition (Self-Affirmation, Control). All participants next watched an extract of a genuine narrative piece in which the central character discussed her liver disease and its link with her previous alcohol consumption. Then, participants completed measures assessing engagement with the narrative and message acceptance. The primary outcome was alcohol consumption, assessed at 7-day follow-up.
Results: Self-affirmed participants reported consuming significantly less alcohol at follow-up compared to baseline (mean 7-day decrease = 5.43 units); there was no change in alcohol consumption for the control group. Immediately post-manipulation, self-affirmed participants (vs. control) showed more message acceptance and reported greater engagement with the information. The impact of self-affirmation on message acceptance was mediated by narrative engagement.
Conclusions: Self-affirmation can promote behavior change following exposure to health information, even when presented in narrative form
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