Coordinated Behavior on Social Media in 2019 UK General Election

Coordinated online behaviors are an essential part of information and influence operations, as they allow a more effective disinformation's spread. Most studies on coordinated behaviors involved manual investigations, and the few existing computational approaches make bold assumptions or oversimplify the problem to make it tractable. Here, we propose a new network-based framework for uncovering and studying coordinated behaviors on social media. Our research extends existing systems and goes beyond limiting binary classifications of coordinated and uncoordinated behaviors. It allows to expose different coordination patterns and to estimate the degree of coordination that characterizes diverse communities. We apply our framework to a dataset collected during the 2019 UK General Election, detecting and characterizing coordinated communities that participated in the electoral debate. Our work conveys both theoretical and practical implications and provides more nuanced and fine-grained results for studying online information manipulation.Comment: Version accepted in Proc. AAAI Intl. Conference on Web and Social Media (ICWSM) 2021. Added dataset DO

Towards better social crisis data with HERMES: Hybrid sensing for EmeRgency ManagEment System

People involved in mass emergencies increasingly publish information-rich contents in online social networks (OSNs), thus acting as a distributed and resilient network of human sensors. In this work, we present HERMES, a system designed to enrich the information spontaneously disclosed by OSN users in the aftermath of disasters. HERMES leverages a mixed data collection strategy, called hybrid crowdsensing, and state-of-the-art AI techniques. Evaluated in real-world emergencies, HERMES proved to increase: (i) the amount of the available damage information; (ii) the density (up to 7x) and the variety (up to 18x) of the retrieved geographic information; (iii) the geographic coverage (up to 30%) and granularity

Linea Guida Multisocietaria per il paziente adulto con diabete o con iperglicemia ricoverato in setting clinico non critico

Introduzione Gruppo di sviluppo della Linea Guida Caratteristiche di una Linea Guida dell’ISS pubblicata sul Sito Nazionale Linee Guida Elenco dei quesiti Quesito 1: premesse, sintesi delle evidenze, raccomandazione, commento Quesito 2: premesse, sintesi delle evidenze, raccomandazione, commento Quesito 3: premesse, sintesi delle evidenze, raccomandazione, commento Quesito 4: premesse, sintesi delle evidenze, raccomandazione, commento Quesito 5: premesse, sintesi delle evidenze, raccomandazione, commento Quesito 6: premesse, sintesi delle evidenze, raccomandazione, commento Quesito 7: premesse, sintesi delle evidenze, raccomandazione, commento Quesito 8: premesse, sintesi delle evidenze, raccomandazione, commento Quesito 9: premesse, sintesi delle evidenze, raccomandazione, commento Quesito 10: premesse, sintesi delle evidenze, raccomandazione, commento Quesito 11: premesse, sintesi delle evidenze, raccomandazione, commento Quesito 12: premesse, sintesi delle evidenze, raccomandazione, commento Discussione Conclusion

Real-world Outcomes of Relapsed/Refractory Diffuse Large B-cell Lymphoma Treated With Polatuzumab Vedotin-based Therapy

: After FDA and EMA approval of the regimen containing polatuzumab vedotin plus rituximab and bendamustine (PolaBR), eligible relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients in Italy were granted early access through a Named Patient Program. A multicentric observational retrospective study was conducted focusing on the effectiveness and safety of PolaBR in everyday clinical practice. Fifty-five patients were enrolled. There were 26 females (47.3%), 32 patients were primary refractory and 45 (81.8%) resulted refractory to their last therapy. The decision to add or not bendamustine was at physician's discretion. Thirty-six patients underwent PolaBR, and 19 PolaR. The 2 groups did not differ in most of baseline characteristics. The final overall response rate was 32.7% (18.2% complete response rate), with a best response rate of 49.1%. Median disease-free survival was reached at 12 months, median progression-free survival at 4.9 months and median overall survival at 9 months, respectively. Overall, 88 adverse events (AEs) were registered during treatment in 31 patients, 22 of grade ≥3. Eight cases of neuropathy occurred, all of grades 1-2 and all related to polatuzumab. The two groups of treatment did not differ for effectiveness endpoints but presented statistically significant difference in AEs occurrence, especially in hematological AEs, in AEs of grade equal or greater than 3 and in incidence of neuropathy. Our data add useful information on the effectiveness of Pola(B)R in the setting of heavily pretreated DLBCL and may also suggest a better tolerability in absence of bendamustine without compromise of efficacy

Rapporto 2007 su consumo e dipendenze da sostanze in Emilia-Romagna.

Report on the state of legal and illegal substances use in the territory of Emilia-Romagna Region.Il report analizza il fenomeno delle dipendenze nel territorio della Regione Emilia-Romagna. La descrizione del fenomeno si sviluppa intorno all\u27analisi degli indicatori individuati dall\u27Osservatorio Europeo delle Dipendenze di Lisbona (OEDT): 1-uso di sostanze nella popolazione generale (questo indicatore va a rilevare i comportamenti nei confronti di alcol e sostanze psicoattive da parte della popolazione generale); 2-prevalenza d\u27uso problematico delle sostanze psicoattive; 3-domanda di trattamento degli utilizzatori di sostanze; 4-mortalit? degli utilizzatori di sostanze; 5-malattie infettive. Altri due importanti indicatori che si stanno sviluppando, e che vengono qui illustrati, sono l\u27analisi delle Schede di Dimissione Ospedaliera (SDO) e gli indicatori relativi alle conseguenza sociali dell\u27uso di droghe (criminalit? droga correlata). Inoltre sono state applicate diverse metodologie standard di stima sia per quantificare la quota parte sconosciuta di utilizzatori di sostanze che non afferiscono ai servizi, sia per identificarne alcune caratteristiche

Geo-Semantic-Parsing: AI-powered geoparsing by traversing semantic knowledge graphs

Online social networks convey rich information about geospatial facets of reality. However in most cases, geographic information is not explicit and structured, thus preventing its exploitation in real-time applications. We address this limitation by introducing a novel geoparsing and geotagging technique called Geo-Semantic- Parsing (GSP). GSP identifies location references in free text and extracts the corresponding geographic co- ordinates. To reach this goal, we employ a semantic annotator to identify relevant portions of the input text and to link them to the corresponding entity in a knowledge graph. Then, we devise and experiment with several efficient strategies for traversing the knowledge graph, thus expanding the available set of information for the geoparsing task. Finally, we exploit all available information for learning a regression model that selects the best entity with which to geotag the input text. We evaluate GSP on a well-known reference dataset including almost 10 k event-related tweets, achieving F1 = 0.66. We extensively compare our results with those of 2 baselines and 3 state-of-the-art geoparsing techniques, achieving the best performance. On the same dataset, competitors obtain F1 ≤ 0.55. We conclude by providing in-depth analyses of our results, showing that the overall superior performance of GSP is mainly due to a large improvement in recall, with respect to existing techniques

Complete remission of recurrent multiple insulin-producing neuroendocrine tumors of the pancreas with somatostatin analogs: a case report and literature review

Abstract Hyperinsulinemic hypoglycemia is most commonly caused by a single, sporadic insulinoma. Multicentric insulinoma disease (insulinomatosis) as well as metachronous neuroendocrine tumors of the pancreas, known also as neuroendocrine adenomatosis, represent a very rare condition, if not associated with multiple endocrine neoplasia type 1 syndrome (MEN1) or Von Hippel Lindau disease. We report a 9-year follow-up of a 41-year-old woman, initially presenting with hypoglycemic syndrome caused by two insulin-producing tumors, who underwent subtotal pancreasectomy in 2012, with histology compatible with multiple small neuroendocrine tumors. An approximately 1-cm insulin-producing tumor recurred at subsequent biochemical and radiological follow-up, and was cured with the somatostatin analog octreotide as a single treatment, until remission of symptoms and complete regression of the pancreatic lesion achieved after only 16 months of treatment. The possible mechanisms for these findings are discussed and the literature is briefly reviewed

A New Case of DRESS Syndrome Induced by Sulfasalazine and Triggered by Amoxicillin

Drug Rash Eosinophilia Systemic Symptoms (DRESS) syndrome is a systemic hypersensitivity reaction characterized by exfoliative dermatitis and maculopapular rash, lymphadenopathy, fever, eosinophilia, leukocytosis, and involvement of internal organs as liver, lung, heart, and kidney; the disorder starts within 2–6 weeks after taking a drug with an incidence that ranges from 1/1000 to 1/10000 exposures. Fatal cases are reported. The exact pathogenesis of DRESS syndrome is not completely understood, while it is reported that amoxicillin could trigger it in patients who are taking allopurinol, sulfasalazine, NSAIDs, carbamazepine, strontium ranelate, lisinopril, lansoprazole, and minocycline. Amoxicillin could act directly, inducing the reactivation of a viral infection (HHV 6 and EBV) with symptoms similar to DRESS syndrome or by reducing the patients’ ability to detoxify the body from substances chronically taken. We describe a case of a patient admitted to our hospital for a DRESS syndrome flared after amoxicilline intake during treatment with sulfasalazine; this combination can activate severe reactions often with an insidious onset that can mimic an infectious disease

CT-guided fine-needle aspiration of abdominal and retroperitoneal small lesions with the coaxial technique using MPR images

Purpose: To demonstrate the advantages of CT-guided fine-needle aspiration (FNA) of abdominal and retroperitoneal small lesions with the coaxial technique using MPR images. Materials and methods: The study included retrospectively 50 patients who underwent CT-guided FNA of abdominal and/or retroperitoneal small lesion (<30 mm). Patients with suspected lymphomas or sarcomas were excluded. Cytology reports were the reference standard. Results: The cytology was diagnostic in 48/50 biopsies (96%): out of 41 neoplastic lesions (85%), 37 were malignant (90.2%) and 4 were benign (9.8%); 7 out of 48 were non-neoplastic (14.6%). No procedural complications were observed (0%). Conclusion: By using MPR images there is an effective improvement in coaxial CT-guided FNA of abdominal and retroperitoneal small lesions

Efficacy of Corticosteroids Alone in the Eradication of Factor VIII Inhibitor in an Old Female with Idiopathic Acquired Haemophilia A: Description of a Case

Acquired haemophilia A (AHA) is a rare and serious disorder mainly affecting elderly patients. It is caused by the production of autoantibodies directed against coagulation factors; patients present with spontaneous bleeding, potentially fatal, in the absence of familial or personal history. Autoimmune disorders, infections, solid and hematologic tumors, and drugs are predisposing factors, but up to 50 percent of cases remain unexplained. The diagnosis of AHA is confirmed by specific laboratory tests; and the therapy is a clinical challenge, due to the fact that older patients are often affected by comorbidities. By passing agents may be used when persistent bleeding or haemodynamic instability is observed; corticosteroids, alone or with immunosuppressive therapy, are necessary to inhibit the production of the autoantibodies. We describe a case in which steroids in monotherapy successfully, safely, and persistently inhibited the production of anti-Factor VIII antibodies, in an old patient admitted after rheumatologic consult