カンケイ キカンカン ニオケル ショウガイ ガ アル コドモ ノ ジョウホウ キョウユウ システム ノ ゲンジョウ ト カダイ

文部科学省ギガスクール構想の前倒しにより，2021年度以降，すべての児童生徒にタブレット端末等のICT機器が配布されることとなった。教育現場でのICT活用は学習指導要領に示されている通り，今後も一層推進されていくことになるが，教員のICT活用は進んでいない。特に特別支援教育における障害がある子どもの情報共有においては，ICTを活用した手段が最も効果的であると思われるものの，その事例はほとんど報告されていない。障害がある子どもの情報共有は本人の健康管理，体調管理，学習目標への到達度を図るためには極めて有効な手段である。ではそれを遮っている背景要因は何か。進捗を妨げる壁はどこにあるのか。本論では学校の伝統的な慣習や教員の個人情報に関する意識の問題，またICT活用への誤解などからその要因を明らかにするとともに，課題をクリアし子どもの情報共有におけるICT活用を進展させる方法論についてまとめていく

Spontaneous Bilateral Pneumothorax in a Patient with Anorexia Nervosa: The Management of Prolonged Postoperative Air Leakage

A 24-year-old Japanese female with anorexia nervosa presented to our hospital for bilateral pneumothorax, and 12-Fr thoracostomy catheters were inserted into the bilateral pleural cavities. On hospital day 9, a thoracoscopic bullectomy was performed. However, air leakage relapsed on both sides on postoperative day 1. The air leakage on the right side was particularly persistent, and we switched the drainage to a Heimlich valve. Both lungs expanded gradually and the chest tube was removed on postoperative day 19. Passive pleural drainage might be an option for prolonged air leakage after a bullectomy in patients with anorexia nervosa

AKARI/FIS Mapping of the ISM-Wind Bow Shock around Alpha Ori

We present 10' x 50' scan maps around an M supergiant Alpha Ori at 65, 90, 140 and 160 microns obtained with the AKARI Infrared Astronomy Satellite. Higher spatial resolution data with the exact analytic solution permit us to fit the de-projected shape of the stellar wind bow shock around Alpha Ori to have the stand-off distance of 4.8', position angle of 55 degrees and inclination angle of 56 degrees. The shape of the bow shock suggests that the peculiar velocity of Alpha Ori with respect to the local medium is v_* = 40 (n_H)^(-1/2), where n_H is the hydrogen nucleus density at Alpha Ori. We find that the local medium is of n_H = 1.5 to 1.9 cm^(-3) and the velocity of the local flow is at 11 km s^(-1) by using the most recent astrometric solutions for Alpha Ori under the assumption that the local medium is moving away from the Orion OB 1 association. AKARI images may also reveal a vortex ring due to instabilities on the surface of the bow shock as demonstrated by numerical models. This research exemplifies the potential of AKARI All-Sky data as well as follow-up observations with Herschel Space Telescope and Stratospheric Observatory for Infrared Astronomy for this avenue of research in revealing the nature of interaction between the stellar wind and interstellar medium.Comment: 8 pages, 2 figures, to be published in PASJ Vol. 60 Special Issue on Recent Results from AKAR

A Herschel study of Planetary Nebulae

We present Herschel PACS and SPIRE images of the dust shells around the planetary nebulae NGC 650, NGC 6853, and NGC 6720, as well as images showing the dust temperature in their shells. The latter shows a rich structure, which indicates that internal extinction in the UV is important despite the highly evolved status of the nebulae.Comment: 2 pages, 1 figure, 2012, proceedings IAU Symposium 283 Planetary Nebulae: An Eye to the Futur

Detached shells as tracers of AGB-ISM bow shocks

New Spitzer imaging observations have revealed the structure around the Mira variable star R Hya to be a one-sided parabolic arc 100 arcsec to the West stretching from North to South. We successfully model R Hya and its surroundings in terms of an interaction of the stellar wind from an asymptotic giant branch (AGB) star with the interstellar medium (ISM) the star moves through. Our three-dimensional hydrodynamic simulation reproduces the structure as a bow shock into the oncoming ISM. We propose this as another explanation of detached shells around such stars which should be considered alongside current theories of internal origin. The simulation predicts the existence of a tail of ram-pressure-stripped AGB material stretching downstream. Indications for such a tail behind R Hya are seen in IRAS maps.Comment: 5 pages, 3 colour figures, submitted to MNRAS letters, revised version after referee's comment

EGFR Mutation is a Prognostic Factor in Lung Cancer Patients with Pleural Dissemination Detected During or After Surgery

Background. Primary lung tumors are sometimes resected when either pleural dissemination (PD) or malignant pleural effusion (MPE) exists. This study clarified the prognostic factors for non-small cell lung cancer (NSCLC) with either PD and MPE, or both, detected during or after surgery. Patients and Methods. We examined patients with NSCLC from a multicenter database who had either PD, MPE, or both, detected during or after surgery between 2005 and 2015. Hazard ratios and 95% confidence intervals were estimated using the Cox proportional hazards model adjusted for potential confounding factors. Results. Among 9463 registered patients, PD, MPE, or both, were found in 114 patients with NSCLC during or after surgery. Primary tumor resection and exploratory thoracotomy were performed in 65 and 49 patients, respectively. In univariate analysis, adenocarcinoma, clinically undetected lymph node metastasis (c-N0 or unknown), EGFR mutation, and combination of chemotherapy or tyrosine kinase inhibitors after surgery were better prognostic factors for overall survival (OS), whereas in the multivariate analysis, adenocarcinoma, clinically undetected lymph node metastasis, and EGFR mutation were favorable independent prognostic factors in OS. Additionally, limited to patients with EGFR mutation, patients with primary lung tumor resection showed a significantly better 5-year OS than those with exploratory thoracotomy (86.4 vs. 44.8%; p Conclusion. Our findings show that surgical resection of primary tumors could improve the prognosis of patients with PD, MPE, or both, detected during or after surgery when the tumors harbor an EGFR mutation

ラットCD5抗原の構造と発現

The CD5 molecule is a lymphocyte differentiating antigen with mw. of 67,000, ex pressed on a majority of thymocytes, peripheral T cells and a subpopulation of B cells. We have isolated and characterized rat CD5 cDNA clones from the Wistar rat thymus cDNA library. A clone R5c64 was found to contain a 2.1 kb full-length cDNA insert. The deduced amino acid sequence was comprised of an amino-terminal extracellular domain of 344 residues, a transmembrane region of 31 residues, and a carboxyl-terminal domain of 93 residues with a leader peptide of 23 residues. The extracellular domain contained 22 cysteine residues, all of which were highly conserved among rat, mouse and human in position and in number, and were divided into two homologous subregions by a threonine/proline-rich region. The rat CD5 had a 85% amino acid identity with the murine CD5 and a 64% identity with its human counterpart for the whole peptide. In contrast, the cytoplasmic domain was 97% and 87% identical with those of mouse and human homologues, respectively. This implied an important functional property of this domain. A mAb R1-3B3 was shown to recognize rat CD5 antigens expressed on COS cells transfected with the insert DNA. We could also demonstrate rat CD5 expression on a subset of B cells. Analysis of RFLP of rat genomes showed allelic variants in some strains