The z=5.8 Quasar SDSSp J1044-0125: A Peek at Quasar Evolution?

The newly discovered z=5.8 quasar SDSSp J104433.04-012502.2 was recently detected in X-rays and found to be extremely X-ray weak. Here we present the hardness ratio analysis of the XMM-Newton observation. We consider various models to explain the detection in the soft X-ray band and non-detection in the hard band, together with its X-ray weakness. We show that the source may have a steep power-law slope, with an absorber partially covering the continuum. This may be X-ray evidence to support the argument of Mathur (2000) that narrow line Seyfert 1 galaxies, which show steep power-law slopes, might be the low redshift, low luminosity analogues of the high redshift quasars. Heavily shrouded and steep X-ray spectrum quasars may indeed represent the early stages of quasar evolution (Mathur 2000, Fabian 1999) and SDSSp J104433.04-012502.2 is possibly giving us a first glimpse of the physical evolution of quasar properties.Comment: To appear in A

Giant electrocaloric effect in thin film Pb Zr_0.95 Ti_0.05 O_3

An applied electric field can reversibly change the temperature of an electrocaloric material under adiabatic conditions, and the effect is strongest near phase transitions. This phenomenon has been largely ignored because only small effects (0.003 K V^-1) have been seen in bulk samples such as Pb0.99Nb0.02(Zr0.75Sn0.20Ti0.05)0.98O3 and there is no consensus on macroscopic models. Here we demonstrate a giant electrocaloric effect (0.48 K V^-1) in 300 nm sol-gel PbZr0.95Ti0.05O3 films near the ferroelectric Curie temperature of 222oC. We also discuss a solid state device concept for electrical refrigeration that has the capacity to outperform Peltier or magnetocaloric coolers. Our results resolve the controversy surrounding macroscopic models of the electrocaloric effect and may inspire ab initio calculations of electrocaloric parameters and thus a targeted search for new materials.Comment: 5 pages, 4 figure

Patient safety and estimation of renal function in patients prescribed new oral anticoagulants for stroke prevention in atrial fibrillation

OBJECTIVE: In clinical trials of dabigatran and rivaroxaban for stroke prevention in atrial fibrillation (AF), drug eligibility and dosing were determined using the Cockcroft-Gault equation to estimate creatine clearance as a measure of renal function. This cross-sectional study aimed to compare whether using estimated glomerular filtration rate (eGFR) by the widely available and widely used Modified Diet in Renal Disease (MDRD) equation would alter prescribing or dosing of the renally excreted new oral anticoagulants. PARTICIPANTS: Of 4712 patients with known AF within a general practitioner-registered population of 930 079 in east London, data were available enabling renal function to be calculated by both Cockcroft-Gault and MDRD methods in 4120 (87.4%). RESULTS: Of 4120 patients, 2706 were <80 years and 1414 were ≥80 years of age. Among those ≥80 years, 14.9% were ineligible for dabigatran according to Cockcroft-Gault equation but would have been judged eligible applying MDRD method. For those <80 years, 0.8% would have been incorrectly judged eligible for dabigatran and 5.3% would have received too high a dose. For rivaroxaban, 0.3% would have been incorrectly judged eligible for treatment and 13.5% would have received too high a dose. CONCLUSIONS: Were the MDRD-derived eGFR to be used instead of Cockcroft-Gault in prescribing these new agents, many elderly patients with AF would either incorrectly become eligible for them or would receive too high a dose. Safety has not been established using the MDRD equation, a concern since the risk of major bleeding would be increased in patients with unsuspected renal impairment. Given the potentially widespread use of these agents, particularly in primary care, regulatory authorities and drug companies should alert UK doctors of the need to use the Cockcroft-Gault formula to calculate eligibility for and dosing of the new oral anticoagulants in elderly patients with AF and not rely on the MDRD-derived eGFR

Dynamics of top-down factors with relation to ecological attributes of an endangered species Commiphora wightii

Present study was aimed to explore the influence of top down factors on ecological attributes of Commiphora wightii collected from seven districts of arid and semi arid parts of the Rajasthan. Ecological variables in respect of 46 accessions of this species were quantified. To assess the explanatory factors governing quantified ecological variables, soil samples were collected to analyze soil texture, soil EC, pH, available potassium, available phosphorus and total soil nitrogen. Results showed that there was a specific relationship between soil variables and occurence of C. wightii. The mid ranges of potassium (200-300 kg/ha) emerged as favourable to have better density and health of C. wightii: This is the first report on regulatory role of potassium on distribution and occurrence of C. wightii