Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice

Age-related depletion of estrogens and androgens is associated with an increase in Alzheimer's disease (AD) brain pathology and diminished cognitive function. Here we investigated AD-associated molecular and cellular changes in brains of aged hypogonadal (hpg) male and female mice. hpg Mice have a spontaneous, inactivating genetic mutation in the GnRH gene resulting in lifelong deficiency of gonadotropins and gonadal sex hormones. Western blot analysis revealed low levels of amyloid precursor protein and high levels of presenilin 1, amyloid precursor protein C-terminal fragment, and beta-amyloid 42 in brains of aged male, but not female, hpg mice. Changes were confined to the hippocampus and were not evident in the cerebellum or other brain tissues. Male hpg mice tended to have lower levels of IL-1 beta protein than male littermate controls. Immunohistochemical staining of the basal forebrain revealed that male hpg mice had lower choline acetyltransferase levels per neuron compared with controls. These AD-like changes specific to male hpg mice supports a link between androgen depletion and the development of AD pathology

Particle size distribution and mineralogy of Brazilian Ferralsols: Significance for the structure and hydraulic properties.

The Cerrados Biome is one of the major regions of Brazil with 24% of the Brazilian territory (204.106 ha). It is mainly located in the center of Brazil and corresponds to the whole Central Plateau. About 49% of the soils are Ferralsols and approximately 79.106 ha of these soils are dedicated to agriculture. The main characteristics of Ferralsols are a poor horizonation, a weak development of the macrostructure, and a strong submillimetric granular microstructure

Spin- and charge-density oscillations in spin chains and quantum wires

We analyze the spin- and charge-density oscillations near impurities in spin chains and quantum wires. These so-called Friedel oscillations give detailed information about the impurity and also about the interactions in the system. The temperature dependence of these oscillations explicitly shows the renormalization of backscattering and conductivity, which we analyze for a number of different impurity models. We are also able to analyze screening effects in one dimension. The relation to the Kondo effect and experimental consequences are discussed.Comment: Final published version. 15 pages in revtex format including 22 epsf-embedded figures. The latest version in PDF format is available from http://fy.chalmers.se/~eggert/papers/density-osc.pd

Constraints on the CMB temperature redshift dependence from SZ and distance measurements

The relation between redshift and the CMB temperature, $T_{CMB}(z)=T_0(1+z)$ is a key prediction of standard cosmology, but is violated in many non-standard models. Constraining possible deviations to this law is an effective way to test the $\Lambda$CDM paradigm and search for hints of new physics. We present state-of-the-art constraints, using both direct and indirect measurements. In particular, we point out that in models where photons can be created or destroyed, not only does the temperature-redshift relation change, but so does the distance duality relation, and these departures from the standard behaviour are related, providing us with an opportunity to improve constraints. We show that current datasets limit possible deviations of the form $T_{CMB}(z)=T_0(1+z)^{1-\beta}$ to be $\beta=0.004\pm0.016$ up to a redshift $z\sim 3$. We also discuss how, with the next generation of space and ground-based experiments, these constraints can be improved by more than one order of magnitude.Comment: 27 pages, 11 figure

Dissociation cross sections of ground-state and excited charmonia with light mesons in the quark model

We present numerical results for the dissociation cross sections of ground-state, orbitally- and radially-excited charmonia in collisions with light mesons. Our results are derived using the nonrelativistic quark model, so all parameters are determined by fits to the experimental meson spectrum. Examples of dissociation into both exclusive and inclusive final states are considered. The dissociation cross sections of several C=(+) charmonia may be of considerable importance for the study of heavy ion collisions, since these states are expected to be produced more copiously than the J/psi. The relative importance of the productions of ground-state and orbitally-excited charmed mesons in a pion-charmonium collision is demonstrated through the $\sqrt {s}$-dependent charmonium dissociation cross sections.Comment: 9 pages, 8 figure

BB Intermeson Potentials in the Quark Model

In this paper we derive quark model results for scattering amplitudes and equivalent low energy potentials for heavy meson pairs, in which each meson contains a heavy quark. This "BB" system is an attractive theoretical laboratory for the study of the nuclear force between color singlets; the hadronic system is relatively simple, and there are lattice gauge theory (LGT) results for V_BB(r) which may be compared to phenomenological models. We find that the quark model potential (after lattice smearing) has qualitative similarities to the LGT potential in the two B*B* channels in which direct comparison is possible, although there is evidence of a difference in length scales. The quark model prediction of equal magnitude but opposite sign for I=0 and I=1 potentials also appears similar to LGT results at intermediate r. There may however be a discrepancy between the LGT and quark model I=1 BB potentials. A numerical study of the two-meson Schrodinger equations in the (bqbar)(bqbar) and (cqbar)(cqbar) sectors with the quark model potentials finds a single "molecule", in the I=0 BB* sector. Binding in other channels might occur if the quark model forces are augmented by pion exchange.Comment: 30 pages, 5 figures, revtex and epsfig. Submitted to Phys. Rev.

Series study of the One-dimensional S-T Spin-Orbital Model

We use perturbative series expansions about a staggered dimerized ground state to compute the ground state energy, triplet excitation spectra and spectral weight for a one-dimensional model in which each site has an S=\case 1/2 spin ${\bf S}_i$ and a pseudospin ${\bf T}_i$, representing a doubly degenerate orbital. An explicit dimerization is introduced to allow study of the confinement of spinon excitations. The elementary triplet represents a bound state of two spinons, and is stable over much of the Brillouine zone. A special line is found in the gapped spin-liquid phase, on which the triplet excitation is dispersionless. The formation of triplet bound states is also investigated.Comment: 9 pages, 9 figure

Numerical convergence of the block-maxima approach to the Generalized Extreme Value distribution

In this paper we perform an analytical and numerical study of Extreme Value distributions in discrete dynamical systems. In this setting, recent works have shown how to get a statistics of extremes in agreement with the classical Extreme Value Theory. We pursue these investigations by giving analytical expressions of Extreme Value distribution parameters for maps that have an absolutely continuous invariant measure. We compare these analytical results with numerical experiments in which we study the convergence to limiting distributions using the so called block-maxima approach, pointing out in which cases we obtain robust estimation of parameters. In regular maps for which mixing properties do not hold, we show that the fitting procedure to the classical Extreme Value Distribution fails, as expected. However, we obtain an empirical distribution that can be explained starting from a different observable function for which Nicolis et al. [2006] have found analytical results.Comment: 34 pages, 7 figures; Journal of Statistical Physics 201

Star Formation and Dynamics in the Galactic Centre

The centre of our Galaxy is one of the most studied and yet enigmatic places in the Universe. At a distance of about 8 kpc from our Sun, the Galactic centre (GC) is the ideal environment to study the extreme processes that take place in the vicinity of a supermassive black hole (SMBH). Despite the hostile environment, several tens of early-type stars populate the central parsec of our Galaxy. A fraction of them lie in a thin ring with mild eccentricity and inner radius ~0.04 pc, while the S-stars, i.e. the ~30 stars closest to the SMBH (<0.04 pc), have randomly oriented and highly eccentric orbits. The formation of such early-type stars has been a puzzle for a long time: molecular clouds should be tidally disrupted by the SMBH before they can fragment into stars. We review the main scenarios proposed to explain the formation and the dynamical evolution of the early-type stars in the GC. In particular, we discuss the most popular in situ scenarios (accretion disc fragmentation and molecular cloud disruption) and migration scenarios (star cluster inspiral and Hills mechanism). We focus on the most pressing challenges that must be faced to shed light on the process of star formation in the vicinity of a SMBH.Comment: 68 pages, 35 figures; invited review chapter, to be published in expanded form in Haardt, F., Gorini, V., Moschella, U. and Treves, A., 'Astrophysical Black Holes'. Lecture Notes in Physics. Springer 201