Trithorax group proteins: switching genes on and keeping them active

Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein MLL in leukaemia. However, in terms of molecular analysis, they have lived in the shadow of their more famous counterparts, the PcG proteins. Recent advances have improved our understanding of TrxG protein function and demonstrated that the heterogeneous group of TrxG proteins is of critical importance in the epigenetic regulation of the cell cycle, senescence, DNA damage and stem cell biology

Anti-Unruh Phenomena

We find that a uniformly accelerated particle detector coupled to the vacuum can cool down as its acceleration increases, due to relativistic effects. We show that in (1+1)-dimensions, a detector coupled to the scalar field vacuum for finite timescales (but long enough to satisfy the KMS condition) has a KMS temperature that decreases with acceleration, in certain regimes. This contrasts with the heating that one would expect from the Unruh effect.Comment: 6 pages, 5 figures. RevTex 4.1. V2. Typos in the plots labeling corrected and plot rescaled. New discussion section added. Title change

On the Born-Oppenheimer approximation of diatomic molecular resonances

We give a new reduction of a general diatomic molecular Hamiltonian, without modifying it near the collision set of nuclei. The resulting effective Hamiltonian is the sum of a smooth semiclassical pseudodifferential operator (the semiclassical parameter being the inverse of the square-root of the nuclear mass), and a semibounded operator localised in the elliptic region corresponding to the nuclear collision set. We also study its behaviour on exponential weights, and give several applications where molecular resonances appear and can be well located.Comment: 22 page