Ribosome recycling induces optimal translation rate at low ribosomal availability

Funding statement The authors thank BBSRC (BB/F00513/X1, BB/I020926/1 and DTG) and SULSA for funding. Acknowledgement The authors thank R. Allen, L. Ciandrini, B. Gorgoni and P. Greulich for very helpful discussions and careful reading of the manuscript.Peer reviewedPublisher PD

The changes in leaf reflectance of sugar maple seedlings (Acer saccharum Marsh) in response to heavy metal stress

The effects of heavy metal stress on leaf reflectance of sugar maple seedlings (Acer saccharum Marsh) are examined. It is found that sugar maple seedlings treated with anomalous amounts of heavy metals in the rooting medium exhibited an increased leaf reflectance over the entire range of investigated wavelengths, from 475 to 1650 nm. These results conform to those of a previous investigation in the wavelengths from 475 to 660nm, but tend to contradict the previous study in the near infrared wavelengths from 1000 to 1650nm. The differences may possible be due to different water regimes in the two investigations

Reactive attachment disorder in the general population: a hidden ESSENCE disorder

Reactive attachment disorder (RAD) is a severe disorder of social functioning. Previous research has shown that children with RAD may have poor cognitive and language abilities; however, findings mainly come from biased, institutionalised samples. This paper describes the characteristics of all children who were given a suspected or likely diagnosis of reactive attachment disorder in an epidemiological study of approximately 1,600 children investigating the prevalence of RAD in the general population. We found that children with RAD are more likely to have multiple comorbidities with other disorders, lower IQs than population norms, more disorganised attachment, more problem behaviours, and poorer social skills than would be found in the general population and therefore have a complex presentation than can be described as ESSENCE. We discuss the clinical and educational implications

The relationship between amyloid structure and cytotoxicity

Self-assembly of proteins and peptides into amyloid structures has been the subject of intense and focused research due to their association with neurodegenerative, age-related human diseases and transmissible prion diseases in humans and mammals. Of the disease associated amyloid assemblies, a diverse array of species, ranging from small oligomeric assembly intermediates to fibrillar structures, have been shown to have toxic potential. Equally, a range of species formed by the same disease associated amyloid sequences have been found to be relatively benign under comparable monomer equivalent concentrations and conditions. In recent years, an increasing number of functional amyloid systems have also been found. These developments show that not all amyloid structures are generically toxic to cells. Given these observations, it is important to understand why amyloid structures may encode such varied toxic potential despite sharing a common core molecular architecture. Here, we discuss possible links between different aspects of amyloidogenic structures and assembly mechanisms with their varied functional effects. We propose testable hypotheses for the relationship between amyloid structure and its toxic potential in the context of recent reports on amyloid sequence, structure, and toxicity relationships

Persistent Sunward Flow of ~1.6 MeV Protons at 1 Au

The anisotropy of 1.3 to 2.3 MeV protons has been measured with the Caltech Electron/Isotope Spectrometer aboard IMP-7 for periods between prompt solar particle events from 72/273 to 74/2. The diffusive anisotropy, which has been computed by subtracting the independently determined. convective anisotropy from the observed anisotropy, is predominantly directed toward the sun with a typical radial component of 14%

Whole body interaction

In this workshop we explore the notation of whole body interaction. We bring together different disciplines to create a new research direction for study of this emerging form of interaction

BENEFITS OF CONTROLLING SALINE WATER IN COLORADO

The Arkansas River in Colorado is confronted with a salinity issue; the majority of this salinity problem is due to agricultural runoff caused by irrigation. Reducing applications of irrigation water through adoption of more technically efficient irrigation systems is one means of improving water quality in the Arkansas River basin. This research uses positive mathematical programming to model the cropping practices of the farms along the Arkansas River. It examines the affect of acreage and profit levels of these farms given the choice of changing their irrigation technologies.Environmental Economics and Policy,