Mechanomyographic amplitude and frequency responses during dynamic muscle actions: a comprehensive review

The purpose of this review is to examine the literature that has investigated mechanomyographic (MMG) amplitude and frequency responses during dynamic muscle actions. To date, the majority of MMG research has focused on isometric muscle actions. Recent studies, however, have examined the MMG time and/or frequency domain responses during various types of dynamic activities, including dynamic constant external resistance (DCER) and isokinetic muscle actions, as well as cycle ergometry. Despite the potential influences of factors such as changes in muscle length and the thickness of the tissue between the muscle and the MMG sensor, there is convincing evidence that during dynamic muscle actions, the MMG signal provides valid information regarding muscle function. This argument is supported by consistencies in the MMG literature, such as the close relationship between MMG amplitude and power output and a linear increase in MMG amplitude with concentric torque production. There are still many issues, however, that have yet to be resolved, and the literature base for MMG during both dynamic and isometric muscle actions is far from complete. Thus, it is important to investigate the unique applications of MMG amplitude and frequency responses with different experimental designs/methodologies to continually reassess the uses/limitations of MMG

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Exploring the 'New Rural Paradigm' in Europe: eco-economic strategies as a counterforce to the global competitiveness agenda

Rural regions in Europe are facing diverging pathways of development. On the one hand, the influence of urbanisation and the intensification and continued up-scaling of agriculture make it more difficult for many regions to remain distinctive and increase sustainability. Places, as well as goods and services, have become increasingly interchangeable. For many regions an obvious choice is to compete with other regions for global mobile capital and labour. On the other hand, and as a counterforce to these global logics, new strategies, which are more place-based, are being developed, such as the construction of identities or images around new agricultural goods and services. These strategies can be seen in the context of the ‘New Rural Paradigm’ for European rural regions. In the search for new trajectories for sustainable development, different models can be identified: the bio-economy paradigm and the eco-economy. Each model has its own sustainability claim and can be analysed in the context of the overarching development theory of ecological modernisation. The central question in this article is what types of strategies and pathways for eco-economic development can be witnessed in rural regions in Europe? The empirical analysis is based on 62 European cases. Three key eco-economic strategies that show a shift from an agricultural-based development to a more integrative rural and regionally based development are identified. The article concludes with some consistent parameters for understanding the dynamic complexity of rural regional development

The implementation of agricultural policy in China: an actor-oriented perspective

To date, most studies on policy implementation have been conducted from either a top-down or bottom-up perspective. Both approaches have limitations for analyzing policy process, especially in complex, multi-actor or networked circumstances (O’Toole, 2004). To better reflect the changing process of policy implementation, and reveal the interaction of different interest groups, this study uses an actor-oriented perspective to analyze a state- led agricultural policy initiative in the Qinglin County of Hebei Province, China. We conclude that policy implementation is a social process which is constantly being negotiated. Power shifts and re-distribution of policy resources emerge stemming from the strategies and practices devised by different social actors. Based on these findings, we suggest that for a given policy, policy design only plays a limited role towards the desired goal, so do the policy implementation rules. As an important complement, monitoring and supervising mechanism should be introduced into policy implementation process, whereby the actions taken by various social actors at the local level can be responded duly under the supervision. Thus, the uncertainty of policy will be dealt with targeted and timely rather than being set aside until to the end, which is too late

Understanding alternative food networks: exploring the role of short food supply chains in rural development

In this paper we explore the development and incidence of alternative food networks within a European-wide context. By developing a consistent definition of short food supply chains, we address both the morphology and the dynamics of these, and then examine empirical evidence concerning their incidence and rural development impact across seven EU member states. These developments need to be seen as one significant contribution to the current transitions in rural Europe concerning the crisis of conventional intensive and productivist agriculture and the public consumer pressure for a larger variety of distinctive 'quality' food products.