An association of boswellia, betaine and myo-inositol (Eumastós) in the treatment of mammographic breast density. A randomized, double-blind study

Mammographic breast density is a recognized risk factor for breast cancer. The causes that lead to the proliferation of the glandular breast tissue and, therefore, to an increase of breast density are still unclear. However, a treatment strategy to reduce the mammary density may bring about very relevant clinical outcomes in breast cancer prevention. Myo-inositol is a six-fold alcohol of cyclohexane, has already been proved to modulate different pathways: inflammatory, metabolic, oxidative and endocrine processes, in a wide array of human diseases, including cancer and the genesis of mammary gland and breast diseases, like fibrosis, as well as metabolic and endocrine cues. Similarly, boswellic acid and betaine (three-methyl glycine) both inhibit inflammation and exert protective effects on breast physiology. Based on this scientific background, we hypothesized that a combination including, boswellic acid, betaine and myo-inositol would be able to reduce breast density working on different pathways.OBJECTIVE: Mammographic breast density is a recognized risk factor for breast cancer. The causes that lead to the proliferation of the glandular breast tissue and, therefore, to an increase of breast density are still unclear. However, a treatment strategy to reduce the mammary density may bring about very relevant clinical outcomes in breast cancer prevention. Myo-inositol is a six-fold alcohol of cyclohexane, has already been proved to modulate different pathways: inflammatory, metabolic, oxidative and endocrine processes, in a wide array of human diseases, including cancer and the genesis of mammary gland and breast diseases, like fibrosis, as well as metabolic and endocrine cues. Similarly, boswellic acid and betaine (threemethyl glycine) both inhibit inflammation and exert protective effects on breast physiology. Based on this scientific background, we hypothesized that a combinat ion including, boswellic acid, betaine and myo-inositol would be able to reduce breast density working on different pathways. PATIENTS AND METHODS: In this study, seventy-six premenopausal women were randomly assigned to the placebo and the experimental drug arms (Eumastós®) for six months. RESULTS: After 6 months of treatment, statistically significant difference between the two groups was recorded on the breast density reduction (60% vs. 9%), using mammographic as well as ultrasound examination. CONCLUSIONS: Preliminary data collected here with support the starting assumptions,that the association comprising boswellic acid, betaine and myo-inositol significantly reduces mammary density, providing the first evidence for a new and safe approach for the management of mammographic density treatment

Microscopic Entropy of Non-dilatonic Branes: a 2D approach

We investigate non-dilatonic p-branes in the near-extremal, near-horizon regime. A two-dimensional gravity model, obtained from dimensional reduction, gives an effective description of the brane. We show that the AdS_p+2/CFT_p+1 correspondence at finite temperature admits an effective description in terms of a AdS_2/CFT_1 duality endowed with a scalar field, which breaks the conformal symmetry and generates a non-vanishing central charge. The entropy of the CFT_1 is computed using Cardy formula. Fixing in a natural way a free, dimensionless, parameter introduced in the model by a renormalization procedure, we find exact agreement between the CFT_1 entropy and the Bekenstein-Hawking entropy of the brane.Comment: 10 pages, no figure

Effect of nickel in solid solution on hydrogen transport kinetics in low alloy steels

The use of low alloy steels (LAS) in H2S-containing environments in the oil and gas industry is governed by the ISO standard 15156-2 (NACE MR0175-2). One requirement, which has been disputed over the years, is that the nickel (Ni) content shall not exceed 1 wt%. This work investigated the effect of Ni in solid solution on hydrogen diffusion, solubility, and trapping in ferritic/pearlitic research-grade LAS with nominal Ni contents from 0 to 3 wt%. Hydrogen permeability experiments were carried out in a Devanathan-Stachurski setup at 15, 45 and 70 °C. The effective diffusion coefficients, calculated by the tlag method, decreased with increasing Ni content. The sub-surface hydrogen concentration in lattice and trap sites increased with increasing Ni content. There was no difference between the first and subsequent hydrogen permeation transients, suggesting that Ni in solid solution forms reversible traps. The effect of Ni in refining the microstructure may be superimposed on the effect of Ni in solid solution, and should be investigated in future work

On the energy-shell contributions of the three-particle~-~ three-hole excitations

The response functions for the extended second and third random phase approximation are compared. A second order perturbation calculation shows that the first-order amplitude for the direct $3p3h$ excitation from the ground state cancels with those that are engendered by the $1p1h$-$3p3h$ coupling. As a consequence nonvanishing $3p3h$ effects to the $1p1h$ response involve off energy shell renormalization only. On shell $3p3h$ processes are absent.Comment: 12 pages text (LaTex) and 1 figure included, to be published in Phys. Rev.

Bicrossproduct structure of the null-plane quantum Poincare algebra

A nonlinear change of basis allows to show that the non-standard quantum deformation of the (3+1) Poincare algebra has a bicrossproduct structure. Quantum universal R-matrix, Pauli-Lubanski and mass operators are presented in the new basis.Comment: 7 pages, LaTe

Canine Cyclin T1 Rescues Equine Infectious Anemia Virus Tat Trans-Activation in Human Cells

AbstractHuman immunodeficiency virus-1 Tat protein and human Cyclin T1 mediate transcriptional activation by enhancing the elongation efficiency of RNA polymerase II. Activation of transcription of the related equine infectious anemia virus (EIAV) requires a similar protein known as eTat, which does not function in human cells. Expression of equine Cyclin T1 in human cells rescues eTat function, suggesting a general mechanism of transcription activation among lentiviruses. Here we present the cloning of Cyclin T1 from canine D17 osteosarcoma cells, which support EIAV transactivation, and show that canine Cyclin T1 confers eTat transactivation to human cells. A two-amino-acid change, from 79–proline–glycine–80 to 79–histidine–arginine–80, confers on the human Cyclin T1 the ability to cooperate with eTat in transcriptional activation. These findings suggested that the regions of Cyclin T1 that interact with lentiviral Tat proteins and TAR RNA elements form an extended domain, which very likely has a conserved fold

Prediction of stable walking for a toy that cannot stand

Previous experiments [M. J. Coleman and A. Ruina, Phys. Rev. Lett. 80, 3658 (1998)] showed that a gravity-powered toy with no control and which has no statically stable near-standing configurations can walk stably. We show here that a simple rigid-body statically-unstable mathematical model based loosely on the physical toy can predict stable limit-cycle walking motions. These calculations add to the repertoire of rigid-body mechanism behaviors as well as further implicating passive-dynamics as a possible contributor to stability of animal motions.Comment: Note: only corrections so far have been fixing typo's in these comments. 3 pages, 2 eps figures, uses epsf.tex, revtex.sty, amsfonts.sty, aps.sty, aps10.sty, prabib.sty; Accepted for publication in Phys. Rev. E. 4/9/2001 ; information about Andy Ruina's lab (including Coleman's, Garcia's and Ruina's other publications and associated video clips) can be found at: http://www.tam.cornell.edu/~ruina/hplab/index.html and more about Georg Bock's Simulation Group with whom Katja Mombaur is affiliated can be found at http://www.iwr.uni-heidelberg.de/~agboc

European Federation of Periodontology Survey of Postgraduate and Specialist Training in Europe in 2020:Periodontal specialist training in Europe

AIMS: The survey's aim was to establish which universities and other educational organisations deliver postgraduate and specialist training in Periodontology in the 31 countries who are members of the European Federation of Periodontology (EFP) and to obtain details of how these programmes are organised, funded, regulated and evaluated. METHODS: A questionnaire and covering letter were emailed to all national periodontal societies. The questions were on the name of country, official recognition, training programmes, entry to specialist training, specialist training assessment and recognition after completion of training. RESULTS: Twenty‐nine (93%) of national periodontal societies responded. Key findings included the following: Periodontology was reported as being recognised at a national level in 17 countries, there was a three‐year full‐time programme in 12 countries, no fees were charged for specialist training in 10 countries, in 14 countries trainees received annual salaries, end of training (summative) assessments varied from country to country, 12 countries reported that they had a requirement for specialists in Periodontology to complete continuing education to maintain registration as specialists. CONCLUSIONS: This survey has established which universities and other educational organisations deliver postgraduate and specialist training in Periodontology and how these programmes are organised, funded, regulated and evaluated. To provide uniformly high‐quality periodontal care for patients in all European countries, further harmonisation of postgraduate and specialty training in Periodontology would be advantageous