Piezoelectric metamaterial with negative and zero Poisson's ratios

This study presents the finite element–based micromechanical modeling approach to obtain the electromechanical properties of the piezoelectric metamaterial based on honeycomb (HC) cellular networks. The symmetry of the periodic structure was employed to derive mixed boundary conditions (MBCs) analogous to periodic boundary conditions (PBCs). Three classes of hexagonal HC cellular networks, namely, a conventional HC (CHC), a re-entrant HC (RE), and a semi-re-entrant HC (SRE) were considered. The representative volume elements (RVEs) of these three classes of cellular materials were created, and finite element analyses were carried out to analyze the effect of orientation of the ligament on their effective electromechanical properties and their suitability in specific engineering applications. The longitudinally poled piezoelectric HC cellular networks showed an enhanced behavior as compared to the monolithic piezoelectric materials. Moreover, longitudinally poled HC cellular networks demonstrated that, as compared to the bulk constituent, their hydrostatic figure of merit increased and their acoustic impedance decreased by one order of magnitude, respectively, indicating their applicability for the design on hydrophones. Moreover, results showed that cellular metamaterial with tunable electromechanical characteristics and a variety of auxetic behaviors such as negative, positive, or zero Poisson’s ratios could be developed. Such novel HC network-based functional cellular materials are likely to facilitate the design of light-weight devices for various next-generation sensors and actuators

Neurofibromatosis type 1: a rare cause of parotid swelling in a child

Von Recklinghausen disease, also known as neurofibromatosis type 1, is an autosomal dominant disorder that presents as neurocutaneous syndrome. These patients have increased chances of developing other tumors such as plexiform neurofibromas. Plexiform neurofibromas are a proliferation of Schwann cells in the nerve sheath. Affliction of the parotid gland in a young child is a rare presentation of these tumors. We present the management of one such case.Keywords: neurofibromatosis type 1, parotid swelling, plexiform neurofibrom

Instant dynamic response measurements for crack monitoring in metallic beams

This paper investigates the interdependencies of the modal behaviour of a cantilever beam, its dynamic response and crack growth. A methodology is proposed that can predict crack growth in a metallic beam using only its dynamic response. Analytical and numerical relationships are formulated between the fundamental mode and crack growth using the existing literature and finite element analysis (FEA) software, respectively. A relationship between the dynamic response and the modal behaviour is formulated empirically. All three relationships are used to predict crack growth and propagation. The load conditions are considered the same in all of the experiments for both model development and model validation. The predicted crack growth is compared with the visual observations. The overall error is within acceptable limits in all comparisons. The results obtained demonstrate the possibility of diagnosing crack growth in metallic beams at any instant within the operational conditions and environment

A novel approach for damage quantification using the dynamic response of a metallic beam under thermo-mechanical loads

This paper investigates the interdependencies of crack depth and crack location on the dynamic response of a cantilever beam under thermo-mechanical loads. Temperature can influence the stiffness of the structure, thus, the change in stiffness can lead to variation in frequency, damping and amplitude response. These variations are used as key parameters to quantify damage of Aluminum 2024 specimen under thermo-mechanical loads. Experiments are performed on cantilever beams at non-heating (room temperature) and elevated temperature, i.e., 50 °C, 100 °C, 150 °C and 200 °C. This study considers a cantilever beam having various initially seeded crack depth and locations. The analytical, numerical and experimental results for all configurations are found in good agreement. Dynamic response formulation is presented experimentally on beam for the first time under thermo-mechanical loads. Using available experimental data, a novel tool is formulated for in-situ damage assessment in the metallic structures. This tool can quantify and locate damage using the dynamic response and temperature including the diagnosis of subsurface cracking. The obtained results demonstrate the possibility to diagnose the crack growth at any instant within the operational condition under thermo-mechanical loads

Understanding Pharmaceutical Quality by Design

This review further clarifies the concept of pharmaceutical quality by design (QbD) and describes its objectives. QbD elements include the following: (1) a quality target product profile (QTPP) that identifies the critical quality attributes (CQAs) of the drug product; (2) product design and understanding including identification of critical material attributes (CMAs); (3) process design and understanding including identification of critical process parameters (CPPs), linking CMAs and CPPs to CQAs; (4) a control strategy that includes specifications for the drug substance(s), excipient(s), and drug product as well as controls for each step of the manufacturing process; and (5) process capability and continual improvement. QbD tools and studies include prior knowledge, risk assessment, mechanistic models, design of experiments (DoE) and data analysis, and process analytical technology (PAT). As the pharmaceutical industry moves toward the implementation of pharmaceutical QbD, a common terminology, understanding of concepts and expectations are necessary. This understanding will facilitate better communication between those involved in risk-based drug development and drug application review

A headspace-gas chromatography method for isopropanol determination in warfarin sodium products as a measure of drug crystallinity

Coumadin® and several generic products of warfarin sodium (WS) contain the crystalline form (clathrate) in which WS and isopropanol (IPA) are associated in a 2:1 molar ratio. IPA is critical in maintaining the WS crystalline structure. Physicochemical properties of the drug and drug product may change when the crystalline drug transforms to amorphous form. A headspace-gas chromatography (HS-GC) method was developed and validated for IPA determination in the WS drug product. n-propanol (NPA) was used as internal standard and the method was validated for specificity, system suitability, linearity, accuracy, precision, range, limits of detection and quantification, and robustness. The method was specific, with good resolution between IPA and NPA peaks. Chromatographic parameters (retention time, IPA/NPA area ratio, tailing factor, theoretical plates, USP symmetry, capacity factor, selectivity and resolution) were consistent over three days of validation. The analytical method was linear from 2–200 µg mL–1 (0.1–10 % IPA present in the drug product). LOD and LOQ were 0.1 and 2 µg mL–1, respectively. Accuracy at low (2 µg mL–1) and high (200 µg mL–1) IPA concentrations of the calibration curve was 103.3–113.3 and 98.9–102.2 % of the nominal value, resp. The validated method was precise, as indicated by the RSD value of less than 2 % at three concentration levels of the calibration curve. The method reported here was utilized to determine accurately and precisely the IPA content in in-house formulations and commercial products. In summary, IPA determination by HS-GC provides an indirect measure of WS crystallinity in the drug product. Nevertheless, it should be confirmed by another analytical method since IPA from the drug substance is not distinguishable from IPA that may be present outside the drug crystals in a dosage form when prepared by wet granulation with IPA

Extremity tourniquet training at high seas

Background Future navy officers require unique training for emergency medical response in the isolated maritime environment. The authors issued a workshop on extremity bleeding control, using four different commercial extremity tourniquets onboard a training sail ship. The purposes were to assess participants' perceptions of this educational experience and evaluate self-application simplicity while navigating on high seas. Methods A descriptive observational study was conducted as part of a workshop issued to volunteer training officers. A post-workshop survey collected their perceptions about the workshops' content usefulness and adequacy, tourniquet safety, self-application simplicity, and device preference. Tourniquet preference was measured by frequency count while the rest of the studied variables on a one-to-ten Likert scale. Frequencies and percentages were calculated for the studied variables, and application simplicity means compared using the ANOVA test (p < 0.05). Results Fifty-one Spanish training naval officers, aged 20 or 21, perceived high sea workshop content’s usefulness, adequacy, and safety level at 8.6/10, 8.7/10, and 7.5/10, respectively. As for application simplicity, CAT and SAM-XT were rated equally with a mean of 8.5, followed by SWAT (7.9) and RATS (6.9), this one statistically different from the rest (p < 0.01). Windlass types were preferred by 94%. Conclusions The training sail ship’s extremity bleeding control workshop was perceived as useful and its content adequate by the participating midshipmen. Windlass types were regarded as easier to apply than elastic counterparts. They were also preferred by nine out of every ten participants

Prediction of crack depth and fatigue life of an acrylonitrile butadiene styrene cantilever beam using dynamic response

n this article, a methodology is proposed that can be used to predict the crack growth and fatigue life of a cantilever beam made of Acrylonitrile Butadiene Styrene (ABS) manufactured with fused deposition modeling. Three beam configurations based on length (L = 110, 130, and 150 mm) are considered. Empirical relationships are formulated between the natural frequency and the crack growth. The analytical and experimental results are found to be in good agreement for all configurations. Using the experimental data, a global relation is formulated for the crack depth prediction. This global relation is useful for an in situ crack depth prediction with an error of less than 10 %. Later, a residual fatigue life of these specimens is compared with a metallic structure (Aluminum 1050) of similar configuration available in the literature. It is found that the ABS material has more residual fatigue life compared with the metallic structure at the same frequency drop. Based on the remaining fatigue life, ABS material can be a potential material to manufacture machine components under cyclic loads

Evaluation of solar disinfection of water intervention delivered through lady health workers in reduction of diarrheal episodes in under five children

Background: Solar Water Disinfection (SODIS) is a simple, inexpensive and sustainable means of daily household treatment for drinking and storage of water. Globally, over a billion people lack access to safe drinking water. As many as half million under five children die annually due to diarrheal illnesses. Most of these deaths are concentrated in Africa and South Asia. Unsafe water is one of the most critical risk factors for diarrhoea. Systematic reviews indicate that interventions to improve the microbial quality of drinking water in households are effective at reducing diarrhoea illnesses and thereby contribute significantly in reducing deaths due to communicable diseases in children under 5 years. We evaluated the impact of the SODIS intervention on health outcomes and diarrheal episodes in two districts of Punjab province in Pakistan. Methods: A cross-sectional survey was undertaken to assess the impact of solar water disinfection (SODIS) program in two districts of Punjab province, Pakistan. The program was implemented by the Ministry of Health from April 2010- May 2011 in Faisalabad district. We selected Toba Tek Singh as a comparison district for the survey.Results: Analysis with regression models revealed that children had a lower risk of contracting diarrhoea when they consumed high percentages of safe drinks (SODIS), lived in households with good hygiene, washed hands, and belonged to the richest quintile. Diarrhoea prevalence was 10.1 episodes per child per year in the non-intervention area compared to 5.6 episodes per child per year (\u3c 0.0001) in the intervention area. Similarly the proportion of children with dysentery reported in the intervention was half compared to non-intervention area (6.1% vs. 13.9%). SODIS method for purifying drinking water is acceptable and effective in the developing countries. It should be a part of preventive strategies at health system level to control diarrheal illnesses and reduce under five mortalit

Disposition Kinetics and Optimal Dosage of Ciprofloxacin in Healthy Domestic Ruminant Species

The purpose of this experimental study was to determine the disposition kinetics and optimal dosages of ciprofloxacin in healthy domestic ruminant species including adult female buffalo, cow, sheep and goat. The drug was given as a single intramuscular dose of 5 mg/kg. The plasma concentrations of the drug were determined with HPLC and pharmacokinetic variables were determined. The biological half-life (t1/2 β was longer in cows (3.25 ± 0.46 h) followed by intermediate values in buffaloes (3.05 ± 0.20 h) and sheep (2.93 ± 0.45 h) and shorter in goats (2.62 ± 0.39 h). The volume of distribution (Vd) in buffaloes was 1.09 ± 0.06 l/kg, cows 1.24 ± 0.16 l/kg, sheep 2.89 ± 0.30 l/kg and goats 3.76 ± 0.92 l/kg. Total body clearance (ClB) expressed in l/h/kg was minimum in buffaloes 0.25 ± 0.02 followed by values in cows 0.31 ± 0.02 and sheep 0.75 ± 0.04 and maximum in goats 1.09 ± 0.11. An optimal dosage regimen for 12-h interval consisted of 5.17, 5.62, 6.54 and 6.10 mg/kg body weight as priming and 4.84, 5.37, 6.26 and 5.91 mg/kg body weight as maintenance intramuscular dose in buffalo, cow, sheep and goat, respectively. The manufacturers of ciprofloxacin have claimed 5 mg/kg dose to be repeated after 24 h. However, the investigated dosage regimen may be repeated after 12 h to maintain MIC at the end of the dosage interval. Therefore, it is imperative that an optimal dosage regimen be based on the disposition kinetics data determined in the species and environment in which a drug is to be employed clinically