Impact of endometritis on post-partum ovarian cyclicity in dairy cows

Endometritis in dairy cows is a major global issue and has been associated with a decrease in reproductive performance. The aim of this study was to quantify the effect of endometritis (as defined by the presence of any abnormal vaginal discharge after 21 days post-partum) on post-partum ovarian cyclicity in dairy cows. Milk progesterone analysis was used to monitor reproductive cyclicity in 170 dairy cows across three different commercial herds. Associations between the occurrence of endometritis and the incidence risk of a variety of atypical cycle profiles during the calving to conception period were investigated to establish the importance of endometritis on post-partum ovarian activity.Endometritis increased the incidence odds of atypical ovarian profiles (P [less than] 0.05) with prolonged luteal activity being the most affected (P [less than] 0.05), but also showed prolonged time (3 days) to onset of luteal activity after parturition (P [less than] 0.05). Using milk progesterone analysis, we found a relatively low incidence odds for reproductive cycle problems in healthy cows during the calving to conception period. However, the incidence odds of cycle problems, in particular prolonged luteal activity, were high in cows that had experienced endometritis, which would have significantly impaired reproductive function

Milk progesterone on day 5 following insemination in the dairy cow: associated metabolic variables and reproductive consequences

Despite the importance of progesterone on the fertility of lactating dairy cows, the factors that affect post ovulatory progesterone concentration are still unclear. Thus, the aim of the present study was to identify factors associated with the post ovulatory progesterone rise following 1st insemination in lactating dairy cows. Data collected across a number of complimentary studies were compiled to produce a single database of 168 lactating Holstein Friesian dairy cows maintained under commercial conditions. In all animals a number of variables were measured during the insemination period and related to milk progesterone measured on day 5 following 1st artificial insemination (AI). Overall, 44% of cows conceived to 1st AI and while mean day 5 progesterone was not significantly higher in these cows, there was a significant quadratic relationship between milk progesterone concentration and conception rate. While a number of variables showed some association with progesterone concentration, the only variable showing a strong and repeatable relationship was plasma leptin concentration. We conclude that adequate but not excessive progesterone levels on day 5 bring about a better fertility, and plasma leptin concentration may be a much better indicator of metabolic status in lactating dairy cows.Keywords: Conception rate, dairy cow, leptin, metabolic variables, milk progesteron

The Role of Exercise on L-Arginine Nitric Oxide Pathway in Chronic Heart Failure

Chronic heart failure (CHF) is a pathological state with high morbidity and mortality and the full understanding of its genesis remain to be elucidated. In this syndrome, a cascade of neurohormonal and hemodynamic mechanisms, as well as inflammatory mediators, are activated to improve the impaired cardiac function. Clinical and experimental observations have shown that CHF is associated with a generalized disturbance in endothelium-dependent vasodilation, which may contribute to the progression of ventricular and vascular remodelling in this syndrome. There is also accumulating evidence that disturbances in nitric oxide (NO) availability is involved in the development of heart failure at the systemic and cardiac levels. NO is a ubiquitous signalling molecule which causes potent vasodilation, inhibits platelet activation and regulates the contractile properties of cardiac myocytes. It is generated from the amino acid L-arginine via constitutive and inducible isoforms of the enzyme NO synthase (NOS). There is evidence that exercise, a nonpharmacological tool, improves symptoms, fitness (VO2peak), quality of life and NO bioavailability in CHF population. This review examines different aspects of the L-arginine-NO pathway and inflammation in the physiopathology of CHF and highlights the important beneficial effects of exercise in this disease

Strange Particles in Dense Matter and Kaon Condensates

We discuss the role of strangeness in dense matter and especially in neutron stars. The early (in density) introduction of hyperons found in many calculations is probably delayed by the decrease in vector mean field acting on the neutron. The decrease results from both conventional many-body rescattering effects and from the movement towards asymptotic freedom at high densities. Subthreshold $K^-$-meson production by the KaoS collaboration at GSI shows that the $K^-$-mass must be substantially lowered, by $\gtrsim$ 200 MeV at $\rho\sim 2\rho_0$. It is shown that explicit chiral symmetry breaking through the kaon mass may be responsible for $\Sigma^-$-nucleon and $\Xi^-$-nucleon scalar attraction being weaker than obtained by simple quark scaling. The normal mode of the strangeness minus, charge $e^-$, excitation is constructed as a linear combination of $K^-$-meson and $\Sigma^-$, neutron-hole state. Except for zero momentum, where the terms are unmixed the "kaesobar" is a linear combination of these two components.Comment: 10 pages, 8 postscript figures, Talk given at the International Conference on Hypernuclear and Strange Particle Physics (HYP97), Brookhaven Nat'l Lab., USA, October 13-18, 1997, to be published in Nucl. Phys.

Unstable particles in matter at a finite temperature: the rho and omega mesons

Unstable particles (such as the vector mesons) have an important role to play in low mass dilepton production resulting from heavy ion collisions and this has been a subject of several investigations. Yet subtleties, such as the implications of the generalization of the Breit-Wigner formula for nonzero temperature and density, e.g. the question of collisional broadening, the role of Bose enhancement, etc., the possibility of the kinematic opening (or closing) of decay channels due to environmental effects, the problem of double counting through resonant and direct contributions, are often given insufficient emphasis. The present study attempts to point out these features using the rho and omega mesons as illustrative examples. The difference between the two versions of the Vector Meson Dominance Model in the present context is also presented. Effects of non-zero temperature and density, through vector meson masses and decay widths, on dilepton spectra are studied, for concreteness within the framework of a Walecka-type model, though most of the basic issues highlighted apply to other scenarios as well.Comment: text and figures modifie

The Nuclear Sigma Term in the Skyrme Model: Pion-Nucleus Interaction

The nuclear sigma term is calculated including the nuclear matrix element of the derivative of the NN interaction with respect to the quark mass, $m_q\frac{\partial V_{NN}}{\partial m_q}$. The NN potential is evaluated in the skyrmion-skyrmion picture within the quantized product ansatz. The contribution of the NN potential to the nuclear sigma term provides repulsion to the pion-nucleus interaction. The strength of the s-wave pion-nucleus optical potential is estimated including such contribution. The results are consistent with the analysis of the experimental data.Comment: 16 pages (latex), 3 figures (eps), e-mail: [email protected] and [email protected]

Coronal Shock Waves, EUV waves, and their Relation to CMEs. II. Modeling MHD Shock Wave Propagation Along the Solar Surface, Using Nonlinear Geometrical Acoustics

We model the propagation of a coronal shock wave, using nonlinear geometrical acoustics. The method is based on the Wentzel-Kramers-Brillouin (WKB) approach and takes into account the main properties of nonlinear waves: i) dependence of the wave front velocity on the wave amplitude, ii) nonlinear dissipation of the wave energy, and iii) progressive increase in the duration of solitary shock waves. We address the method in detail and present results of the modeling of the propagation of shock-associated extreme-ultraviolet (EUV) waves as well as Moreton waves along the solar surface in the simplest solar corona model. The calculations reveal deceleration and lengthening of the waves. In contrast, waves considered in the linear approximation keep their length unchanged and slightly accelerate.Comment: 15 pages, 7 figures, accepted for publication in Solar Physic

Radio Bursts Associated with Flare and Ejecta in the 13 July 2004 Event

We investigate coronal transients associated with a GOES M6.7 class flare and a coronal mass ejection (CME) on 13 July 2004. During the rising phase of the flare, a filament eruption, loop expansion, a Moreton wave, and an ejecta were observed. An EIT wave was detected later on. The main features in the radio dynamic spectrum were a frequency-drifting continuum and two type II bursts. Our analysis shows that if the first type II burst was formed in the low corona, the burst heights and speed are close to the projected distances and speed of the Moreton wave (a chromospheric shock wave signature). The frequency-drifting radio continuum, starting above 1 GHz, was formed almost two minutes prior to any shock features becoming visible, and a fast-expanding piston (visible as the continuum) could have launched another shock wave. A possible scenario is that a flare blast overtook the earlier transient, and ignited the first type II burst. The second type II burst may have been formed by the same shock, but only if the shock was propagating at a constant speed. This interpretation also requires that the shock-producing regions were located at different parts of the propagating structure, or that the shock was passing through regions with highly different atmospheric densities. This complex event, with a multitude of radio features and transients at other wavelengths, presents evidence for both blast-wave-related and CME-related radio emissions.Comment: 14 pages, 6 figures; Solar Physics Topical Issue, in pres

Chiral Symmetry and light resonances in hot and dense matter

We present a study of the $\pi\pi$ scattering amplitude in the $\sigma$ and $\rho$ channels at finite temperature and nuclear density within a chiral unitary framework. Meson resonances are dynamically generated in our approach, which allows us to analyze the behavior of their associated scattering poles when the system is driven towards chiral symmetry restoration. Medium effects are incorporated in three ways: (a) by thermal corrections of the unitarized scattering amplitudes, (b) by finite nuclear density effects associated to a renormalization of the pion decay constant, and complementarily (c) by extending our calculation of the scalar-isoscalar channel to account for finite nuclear density and temperature effects in a microscopic many-body implementation of pion dynamics. Our results are discussed in connection with several phenomenological aspects relevant for nuclear matter and Heavy-Ion Collision experiments, such as $\rho$ mass scaling vs broadening from dilepton spectra and chiral restoration signals in the $\sigma$ channel. We also elaborate on the molecular nature of $\pi\pi$ resonances.Comment: 14 pages, 14 figures. Contribution to Hard Probes 2008, Illa de A Toxa, Spain, June 8th-14th 200

Chiral and Gluon Condensates at Finite Temperature

We investigate the thermal behaviour of gluon and chiral condensates within an effective Lagrangian of pseudoscalar mesons coupled to a scalar glueball. This Lagrangian mimics the scale and chiral symmetries of QCD. (Submitted to Z. Phys. C)Comment: 20 pages + 7 figures (uuencoded compressed postscript files), University of Regensburg preprint TPR-94-1