Real-Time Rough Extraction of Foreground Objects in MPEG1,2 Compressed Video

This paper describes a new approach to extract foreground objects in MPEG1,2 video streams, in the framework of “rough indexing paradigm”, that is starting from rough data obtained by only partially decoding the compressed stream. In this approach we use both P-frame motion information and I-frame colour information to identify and extract foreground objects. The particularity of our approach with regards to the state of the art methods consists in a robust estimation of camera motion and its use for localisation of real objects and filtering of parasite zones. Secondly, a spatio-temporal filtering of roughly segmented objects at DC resolution is fulfilled using motion trajectory and gaussian-like shape characteristic function. This paradigm results in content description in real time, maintaining a good level of details

Performance evaluation of wavelet-based HD video coding

This paper is intended as a complement of document n3954 and presents some preliminary evaluation of coding efficiency of a scalable wavelet-based encoder. Two HD video sequences have been encoded according to test conditions derived from those used to evaluate the coding efficiency of JSVM and VidWav[4]. Assuming that exploiting temporal redundancy in video coding improves compression efficiency, the aim of this work is to further investigate advantage and disadvantage of applying a motion compensated temporal filtering, in term of compression gain, with respect to pure intra coding

Wavelet-based encoding for HD applications

In the past decades, most of the research on image and video compression has focused on addressing high bandwidth- constrained environments. However, for high resolution and high quality image and video compression, as in the case of High Definition Television (HDTV) or Digital Cinema (DC), the primary constraints are related to quality and flexibility. This paper presents a comparison between scalable wavelet-based video codecs and the state of the art in single point encoding and it investigates the obtainable compression efficiency when using temporal correlation with respect to pure intra coding

Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: results from a national, multicenter survey

Background: There is mounting evidence on the existence of a Pediatric Inflammatory Multisystem Syndrome-temporally associated to SARS-CoV-2 infection (PIMS-TS), sharing similarities with Kawasaki Disease (KD). The main outcome of the study were to better characterize the clinical features and the treatment response of PIMS-TS and to explore its relationship with KD determining whether KD and PIMS are two distinct entities. Methods: The Rheumatology Study Group of the Italian Pediatric Society launched a survey to enroll patients diagnosed with KD (Kawasaki Disease Group - KDG) or KD-like (Kawacovid Group - KCG) disease between February 1st 2020, and May 31st 2020. Demographic, clinical, laboratory data, treatment information, and patients' outcome were collected in an online anonymized database (RedCAP®). Relationship between clinical presentation and SARS-CoV-2 infection was also taken into account. Moreover, clinical characteristics of KDG during SARS-CoV-2 epidemic (KDG-CoV2) were compared to Kawasaki Disease patients (KDG-Historical) seen in three different Italian tertiary pediatric hospitals (Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste; AOU Meyer, Florence; IRCCS Istituto Giannina Gaslini, Genoa) from January 1st 2000 to December 31st 2019. Chi square test or exact Fisher test and non-parametric Wilcoxon Mann-Whitney test were used to study differences between two groups. Results: One-hundred-forty-nine cases were enrolled, (96 KDG and 53 KCG). KCG children were significantly older and presented more frequently from gastrointestinal and respiratory involvement. Cardiac involvement was more common in KCG, with 60,4% of patients with myocarditis. 37,8% of patients among KCG presented hypotension/non-cardiogenic shock. Coronary artery abnormalities (CAA) were more common in the KDG. The risk of ICU admission were higher in KCG. Lymphopenia, higher CRP levels, elevated ferritin and troponin-T characterized KCG. KDG received more frequently immunoglobulins (IVIG) and acetylsalicylic acid (ASA) (81,3% vs 66%; p = 0.04 and 71,9% vs 43,4%; p = 0.001 respectively) as KCG more often received glucocorticoids (56,6% vs 14,6%; p < 0.0001). SARS-CoV-2 assay more often resulted positive in KCG than in KDG (75,5% vs 20%; p < 0.0001). Short-term follow data showed minor complications. Comparing KDG with a KD-Historical Italian cohort (598 patients), no statistical difference was found in terms of clinical manifestations and laboratory data. Conclusion: Our study suggests that SARS-CoV-2 infection might determine two distinct inflammatory diseases in children: KD and PIMS-TS. Older age at onset and clinical peculiarities like the occurrence of myocarditis characterize this multi-inflammatory syndrome. Our patients had an optimal response to treatments and a good outcome, with few complications and no deaths

Opacity modulation for interactive volume rendering of medical images

Interactivity is a main requirement for 3D visualisation of medical images in a variety of clinical applications. The good matching between segmentation and rendering techniques is essential to design easy to use interactive systems which assist the physicians in dynamically creating and manipulating "diagnostically relevant" images from the volumetric data sets. In this work we consider the above problem within an original interactive visualisation paradigm. By this paradigm we want to highlight the twofold clinical requirement of a) detecting and visualising the structures of diagnostic interest (SoDI's) and b) adding to the 3D scene some other structures to create a meaningful visual context. Being the opacity modulation of the different structures a crucial point, we propose an opacity management which reflects the paradigm ideas and operates by means of a twofold indexed look-up table (2iLUT). the 2iLUT consists of a combination of attribute based and object based opacity management and is here designed and experimented in order to combine the time interaction benefits of an indexed opacity setting with the effective handling of the above classification and visualisation clinical requirements

Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways.

Galloflavin (GF), a recently identified lactate dehydrogenase inhibitor, hinders the proliferation of cancer cells by blocking glycolysis and ATP production. The aim of the present experiments was to study the effect of this compound on breast cancer cell lines reproducing different pathological subtypes of this tumor: MCF-7 (the well differentiated form), MDA-MB-231 (the aggressive triple negative tumor) and MCF-Tam (a sub-line of MCF-7 with acquired tamoxifen resistance). We observed marked differences in the energetic metabolism of these cell lines. Compared to MCF-7 cells, both MDA-MB-231 and MCF-Tam cells exhibited higher LDH levels and glucose uptake and showed lower capacity of oxygen consumption. In spite of these differences, GF exerted similar growth inhibitory effects. This result was explained by the finding of a constitutively activated stress response in MDA-MB- 231 and MCF-Tam cells, which reproduce the poor prognosis tumor forms. As a further proof, different signaling pathways were found to be involved in the antiproliferative action of GF. In MCF-7 cells we observed a down regulation of the ERa-mediated signaling needed for cell survival. On the contrary, in MCF-Tam and MDA-MB-231 cells growth inhibition appeared to be contributed by an oxidative stress condition. The prevalent mechanism of cell death was found to be apoptosis induction. Because of the clinical relevance of breast cancer forms having the triple negative and/or chemoresistant phenotype, our results showing comparable effects of GF even on aggressively growing cells encourage further studies to verify the potential of this compound in improving the chemotherapy of breast cancer