Laurence-Moon-Bardet-Biedl Syndrome: A Rare Case Report

Introduction: Laurence-Moon-Bardet-Biedl syndrome (LMBBS) is a rare autosomal-recessive disorder, which is characterized principally by cardinal symptoms of marked central obesity, retinal dystrophy, polydactyly, mental retardation, hypogonadism and renal dysfunction. Case presentation: We report a case of a 20-year-old male who presented to us with history of fever, vomiting and dizziness. He was incidentally diagnosed as a case of LMBBS as the patient was having polydactyly, retinitis pigmentosa, central obesity, hypogonadism and low IQ. Conclusion: Laurence-Moon-Bardet-Biedl syndrome is a very rare syndrome with very low incidence; hence, we are reporting this case. In addition, we advice more diligent approach from various specialties, so that this syndrome can be picked up at an early age

Mirizzi Syndrome: A Rare Cause of Obstructive Jaundice

Mirizzi syndrome was first described by Pablo Luis Mirrizi. The incidence of this syndrome ranges from 0.05% to 4%. Thisrare condition is caused by the obstruction of common hepatic duct or common bile duct due to compression caused byseveral impacted stones or a single large impacted gallstone in Hartmann’s pouch. The clinical presentations may vary fromno symptoms to severe cholangitis. It is a rare cause of obstructive jaundice and hence we are reporting a case to emphasizethat while evaluating a case of obstructive jaundice, one must consider Mirizzi syndrome as a differential diagnosis

Scrub Typhus and Myocarditis: A Rare Complication

Scrub typhus, also called bush typhus, is a zoonotic disease a Gram-negative bacterium. Its presentation may range from nonspecific febrile illness to severe disease, with cardiovascular, renal, hepatic and neurological involvement. Myocarditis is one of the rare complications of scrub typhus. Hence, we are reporting a case of a 50-year-old male, farmer by occupation, presenting to us in multiorgan dysfunction syndrome who developed myocarditis during second week of his illness

Scrub Typhus Presenting as Subdural Hemorrhage with Normal Platelet Counts: A Rare Case Presentation

Scrub typhus is a common zoonotic disease with high case fatality rate. The clinical presentation of this disease may vary from acute febrile illness, thrombocytopenia, gastrointestinal manifestations, coagulopathy to neurological manifestations. The common neurological manifestations are meningitis and meningoencephalitis, whereas subdural hemorrhage, cerebrovascular accident, i.e., intracerebral hemorrhage, infarct, subarachnoid hemorrhage, etc. are among rare neurological presentations. Scrub typhus-induced neurological disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality in complicated scrub typhus infection. Here we report a case of scrub typhus complicated with subdural hemorrhage admitted in our hospital

A Study of Erectile Dysfunction in Male Diabetes Patients and its Correlation with Platelet-Lymphocyte Ratio

Introduction: Erectile dysfunction (ED) constitutes a large burden on society given its high prevalence and impact on quality of life. Diabetes is a common cause of organic ED. Prevalence of ED in diabetes ranges from 35% to 85% depending on the study, versus 26% in general population. Platelet-lymphocyte ratio (PLR) has been detected as an important marker for inflammation. Some studies have identified its role in ED but more research is needed. Material and methods: It was a hospital-based prospective observational study. According to International Index of Erectile Function (IIEF)-5 questionnaire, patients were divided into 4 categories: mild ED with score 17 to 21, mild-to-moderate ED with score 12 to 16, moderate ED with score 8 to 11 and severe ED with score 1 to 7. Presence of ED and its severity was correlated with age, residence, duration of diabetes, glycemic status, lipid profile, PLR, complications, body mass index (BMI), etc. Results: Prevalence of ED in male diabetes patients was found to be 72.4%. Among 110 cases with ED, 8 had mild ED (7.2%), 27 had mild-to-moderate (24.5%), 27 had moderate ED (24.5%) and 48 had severe ED (43.6%). Prevalence of ED was found to be proportional to age. Majority of cases in ED group were those with long-standing diabetes. Correlation of ED with complication of diabetes, like nephropathy and retinopathy, was significant, whereas it was not significant with neuropathy. Significant correlation of ED was found with BMI and PLR. Conclusion: ED prevalence was high among the diabetes patients and it increased with age and duration of the disease. Presence of diabetic complications was significantly associated with ED. BMI was significantly associated with development of ED. PLR was significantly higher in ED group and closely related to severity of ED

Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N′-(substituted)-4-(butan-2-lideneamino)benzohydrazides

AbstractA series of N′-(substituted)-4-(butan-2-ylideneamino)benzohydrazides (1–21) was synthesized and characterized by physicochemical as well as spectral means. The synthesized compounds were screened for their in vitro antimicrobial and anticancer potentials. The synthesized compounds displayed higher antifungal potential as compared to antibacterial potential. Besides having good antifungal potential, the synthesized compounds were having appreciable anticancer potential and a number of compounds displayed higher anticancer potential than the standard drug, carboplatin. The results of QSAR studies demonstrated the importance of steric parameter, molar refractivity (MR), topological parameters, third order molecular connectivity index (3χ), Kier’s first order shape index (κ1) in describing the antimicrobial activity of N′-(substituted)-4-(butan-2-ylideneamino)benzohydrazides

Innovation Strategies in Indian Textile Sector – Evidence from Surat Textile Cluster

Though India has comparative advantage in labour intensive sector like textile, India’s performance in this sector is not too impressive on the export front. In this context, this paper argues that lack of innovation culture could be one of the principal reasons for India’s poor performance. This hypothesis is tested by conducing primary survey in one of the more dynamic textile cluster in Northern India namely, Surat and adjoining areas. Our findings do indicate lack of product as well as organisational innovation culture in this region, which may be a serious bottleneck in competitive export market. We do find that firms score well in respect of marketing innovation which probably suggests that competitive pressure has increased due to the globalization of the economy. Firms are also found to be keen in respect of process innovation to reduce cost in the aftermath of increased pace of competition in the sector

Spectroscopic and Mechanistic Studies of Heterodimetallic Forms of Metallo-β-lactamase NDM-1

In an effort to characterize the roles of each metal ion in metallo-β-lactamase NDM-1, heterodimetallic analogues (CoCo-, ZnCo-, and CoCd-) of the enzyme were generated and characterized. UV–vis, 1H NMR, EPR, and EXAFS spectroscopies were used to confirm the fidelity of the metal substitutions, including the presence of a homogeneous, heterodimetallic cluster, with a single-atom bridge. This marks the first preparation of a metallo-β-lactamase selectively substituted with a paramagnetic metal ion, Co(II), either in the Zn1 (CoCd-NDM-1) or in the Zn2 site (ZnCo-NDM-1), as well as both (CoCo-NDM-1). We then used these metal-substituted forms of the enzyme to probe the reaction mechanism, using steady-state and stopped-flow kinetics, stopped-flow fluorescence, and rapid-freeze-quench EPR. Both metal sites show significant effects on the kinetic constants, and both paramagnetic variants (CoCd- and ZnCo-NDM-1) showed significant structural changes on reaction with substrate. These changes are discussed in terms of a minimal kinetic mechanism that incorporates all of the data

Optimizing Spacing and Nutrient Management for Enhanced Growth and Yield of Summer Green Gram (Vigna radiata L.): A Comprehensive Review

Summer green gram (Vigna radiata L.), a vital legume in many agricultural systems, requires precise agronomic practices to maximize its growth and yield. This review examines the influence of optimized plant spacing and nutrient management on the performance of summer green gram. Proper spacing is crucial for minimizing competition for resources among plants, ensuring adequate sunlight, and promoting effective pest and disease control. Different plant densities and their impact on biomass production, pod formation, and seed quality are analysed. Nutrient management, particularly the balanced application of macro and micronutrients, plays a significant role in enhancing physiological and biochemical processes in the plant. The review highlights the importance of integrating organic and inorganic fertilizers to improve soil fertility, boost microbial activity, and increase nutrient uptake efficiency. Studies indicate that appropriate nitrogen, phosphorus, and potassium levels, along with essential micronutrients like zinc and boron, are vital for optimal plant development and yield. The synergistic effects of spacing and nutrient strategies on green gram's growth parameters, including plant height, leaf area index, nodulation, and chlorophyll content, are explored. This comprehensive review synthesizes current research findings and offers practical recommendations for farmers and agronomists aiming to enhance green gram productivity sustainably. By adopting optimal spacing and tailored nutrient management practices, significant improvements in yield and resource use efficiency can be achieved, contributing to food security and agricultural sustainability. The review underscores the need for continued research to refine these agronomic practices under diverse environmental conditions to fully realize the potential of summer green gram cultivation