Clinical characteristics and survival patterns of subsequent sarcoma, breast cancer, and melanoma after childhood cancer in the DCOG-LATER cohort

PURPOSE: Childhood cancer survivors are at increased risk of developing subsequent malignant neoplasms (SMNs). We compared survival and clinical characteristics of survivors with SMNs (sarcoma, breast cancer, or melanoma) and a population-based sample of similar first malignant neoplasm (FMN) patients.METHODS: We assembled three case series of solid SMNs observed in a cohort of 5-year Dutch childhood cancer survivors diagnosed 1963-2001 and followed until 2014: sarcoma (n = 45), female breast cancer (n = 41), and melanoma (n = 17). Each SMN patient was sex-, age-, and calendar year-matched to 10 FMN patients in the population-based Netherlands Cancer Registry. We compared clinical and histopathological characteristics by Fisher's exact tests and survival by multivariable Cox regression and competing risk regression analyses.RESULTS: Among sarcoma-SMN patients, overall survival [hazard ratio (HR) 1.88, 95% confidence interval (CI) 1.23-2.87] and sarcoma-specific mortality (HR 1.91, 95% CI 1.16-3.13) were significantly worse compared to sarcoma-FMN patients (foremost for soft-tissue sarcoma), with 15-year survival rates of 30.8% and 61.6%, respectively. Overall survival did not significantly differ for breast-SMN versus breast-FMN patients (HR 1.14, 95% CI 0.54-2.37), nor for melanoma-SMN versus melanoma-FMN patients (HR 0.71, 95% CI 0.10-5.00). No significant differences in tumor characteristics were observed between breast-SMN and breast-FMN patients. Breast-SMN patients were treated more often with mastectomy without radiotherapy/chemotherapy compared to breast-FMN patients (17.1% vs. 5.6%).CONCLUSIONS: Survival of sarcoma-SMN patients is worse than sarcoma-FMN patients. Although survival and tumor characteristics appear similar for breast-SMN and breast-FMN patients, treatment differs; breast-SMN patients less often receive breast-conserving therapy. Larger studies are necessary to substantiate these exploratory findings.</p

The Caenorhabditis elegans GATA Factor ELT-1 Works through the Cell Proliferation Regulator BRO-1 and the Fusogen EFF-1 to Maintain the Seam Stem-Like Fate

Seam cells in Caenorhabditis elegans provide a paradigm for the stem cell mode of division, with the ability to both self-renew and produce daughters that differentiate. The transcription factor RNT-1 and its DNA binding partner BRO-1 (homologues of the mammalian cancer-associated stem cell regulators RUNX and CBFβ, respectively) are known rate-limiting regulators of seam cell proliferation. Here, we show, using a combination of comparative genomics and DNA binding assays, that bro-1 expression is directly regulated by the GATA factor ELT-1. elt-1(RNAi) animals display similar seam cell lineage defects to bro-1 mutants, but have an additional phenotype in which seam cells lose their stem cell-like properties and differentiate inappropriately by fusing with the hyp7 epidermal syncytium. This phenotype is dependent on the fusogen EFF-1, which we show is repressed by ELT-1 in seam cells. Overall, our data suggest that ELT-1 has dual roles in the stem-like seam cells, acting both to promote proliferation and prevent differentiation

La cuestion religiosa en el engels premarxista. Estudio de la genesis de un punto de vista en sociologia de las religiones

Thèse de doctorat -- Université catholique de Louvain, 197

Religión y exclusión/marginación*. Pentecostalismo globalizado entre los hispanos en Newark, Nueva Jersey.

The recent, growing literature on Pentecostalism – as well as an ongoing research on Hispanic churches in which I am involved in Newark, the largest city in New Jersey – suggest, among other things, that a fertile encounter is taking place between, on the one hand, Latin Americans pushed into migration by their exclusion and/or marginalization from the ongoing processes of economic globalization, and, on the other hand, the global expansion of Pentecostalism. New immigrants seem to find in Pentecostalism a set of extremely useful socio-religious "tools" to creatively face and overcome the hurdles inherent in the migrant experience. This seems especially true in the case of isolated individuals and small groups moving into milieus where they find themselves in a particularly challenging or disadvantageous situation, be it economic, cultural, linguistic, legal and/or educational. In this brief essay, I will attempt to contextualize and describe some of the dynamics unchained through such encounters between Latin American immigrants and Pentecostal churches, especially as they occur in Newark (NJ), but which seem to recur in similar ways in different places, repeatedly contributing both to expand the probabilities of creative survival for Latin American immigrants under the dire straits of economic globalization, while furthering the worldwide growth of Pentecostalism

La Desmitificación del Marxismo en la Teología de la Liberación

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Notas sobre pentecostalismo y poder entre inmigrantes latinoamericanos en la ciudad de Newark (New Jersey, E.U.A.)

La literatura reciente y creciente sobre el fenómeno pentecostal -al igual que una investigación en la que participo sobre iglesias latinas en Newark, la mayor ciudad del Estado de Nueva Jersey en E.U.A. - sugiere, entre otras cosas, que muchos migrantes latinoamericanos (y otros grupos e individuos negativamente privilegiados) hallan en el pentecostalismo una suerte de "caja de herramientas" socio-religiosas extremadamente útiles para enfrentar y superar creativamente las dificultades inherentes a la migración, especialmente en el caso de personas aisladas migrando a lugares donde se hallan en relativa desventaja económica, cultural, lingüística, legal y/o educacional. En este corto ensayo se intenta simplemente enumerar y describir algunas de las dinámicas desencadenadas en ese encuentro entre migrantes latinoamericanos e iglesias pentecostales, que parecen repetirse de maneras análogas en distintos sitios, y que reiteradamente parecen contribuir a aumentar las posibilidades de supervivencia creativa de migrantes latinoamericanos en situación de dificultad.<br>The recent, growing literature on Pentecostalism - as well as an ongoing research on Hispanic churches in which I am involved in Newark, the largest city in New Jersey - suggest, among other things, that many Latin American immigrants (and other groups equally negatively privileged) seem to find in Pentecostalism a set of extremely useful socio-religious "toolkit" to creatively face and overcome the hurdles inherent in the migrant experience, especially in the case of isolated individuals and small groups moving into milieus where they find themselves in a particularly challenging or disadvantageous situation, be it economic, cultural, linguistic, legal and/or educational. In this brief essay, I will attempt to contextualize and describe some of the dynamics unchained through such encounters between Latin American immigrants and Pentecostal churches, especially as they occur in Newark (NJ), but which seem to recur in similar ways in different places, repeatedly contributing both to expand the probabilities of creative survival for Latin American immigrants under duress

La Desmitificación del Marxismo en la Teología de la Liberación

no tien