Nonlinear elasticity of composite networks of stiff biopolymers with flexible linkers

Motivated by recent experiments showing nonlinear elasticity of in vitro networks of the biopolymer actin cross-linked with filamin, we present an effective medium theory of flexibly cross-linked stiff polymer networks. We model such networks by randomly oriented elastic rods connected by flexible connectors to a surrounding elastic continuum, which self-consistently represents the behavior of the rest of the network. This model yields a crossover from a linear elastic regime to a highly nonlinear elastic regime that stiffens in a way quantitatively consistent with experiment.Comment: 4 pages, 3 figure

Multi-scale strain-stiffening of semiflexible bundle networks

Bundles of polymer filaments are responsible for the rich and unique mechanical behaviors of many biomaterials, including cells and extracellular matrices. In fibrin biopolymers, whose nonlinear elastic properties are crucial for normal blood clotting, protofibrils self-assemble and bundle to form networks of semiflexible fibers. Here we show that the extraordinary strain-stiffening response of fibrin networks is a direct reflection of the hierarchical architecture of the fibrin fibers. We measure the rheology of networks of unbundled protofibrils and find excellent agreement with an affine model of extensible wormlike polymers. By direct comparison with these data, we show that physiological fibrin networks composed of thick fibers can be modeled as networks of tight protofibril bundles. We demonstrate that the tightness of coupling between protofibrils in the fibers can be tuned by the degree of enzymatic intermolecular crosslinking by the coagulation Factor XIII. Furthermore, at high stress, the protofibrils contribute independently to the network elasticity, which may reflect a decoupling of the tight bundle structure. The hierarchical architecture of fibrin fibers can thus account for the nonlinearity and enormous elastic resilience characteristic of blood clots.Comment: 27 pages including 8 figures and Supplementary Dat

Influence of single-neutron stripping on near-barrier ⁶He+²⁰⁸Pb and ⁸He+²⁰⁸Pb elastic scattering

The influence of single-neutron stripping on the near-barrier elastic scattering angular distributions for the 6,8He+208Pb systems is investigated through coupled reaction channels (CRC) calculations fitting recently published data to explore the differences in the absorptive potential found in the scattering of these two neutron-rich nuclei. The inclusion of the coupling reduces the elastic cross section in the Coulomb-nuclear interference region for 8He scattering, whereas for 6He its major impact is on the large-angle elastic scattering. The real and imaginary dynamic polarization potentials are obtained by inverting the CRC elastic scattering S-matrix elements. These show that the main absorptive features occur between 11 and 12 fm for both projectiles, while the attractive features are separated by about 1 fm, with their main structures occurring at 10.5 fm for 6He and 11.5 fm for 8He

Spin 1 inversion: a Majorana tensor force for deuteron alpha scattering

We demonstrate, for the first time, successful S-matrix to potential inversion for spin one projectiles with non-diagonal $S^j_{ll'}$ yielding a $T_{\rm R}$ interaction. The method is a generalization of the iterative-perturbative, IP, method. We present a test case indicating the degree of uniqueness of the potential. The method is adapted, using established procedures, into direct observable to potential inversion, fitting $\sigma$, ${\rm i}T_{11}$, $T_{20}$, $T_{21}$ and $T_{22}$ for d + alpha scattering over a range of energies near 10 MeV. The $T_{\rm R}$ interaction which we find is very different from that proposed elsewhere, both real and imaginary parts being very different for odd and even parity channels.Comment: 7 pages Revtex, 4 ps figure

Landmark vs. geometry learning: Explaining female rats' selective preference for a landmark

Rats were trained in a triangular-shaped pool to find a hidden platform, whose location was defined in terms of two sources of information, a landmark outside the pool and a particular corner of the pool. Subsequent test trials without the platform pitted these two sources of information against one another. In Experiment 1 this test revealed a clear, although selective, sex difference. As in previous experiments, females spent more time in an area of the pool that corresponded to the landmark, but here only when it was a cone but not when it was a pyramid. Males, on the other hand, always spent more time in the distinctive corner of the pool. Experiments 2 and 3 were only with female rats. In Experiment 2 two identical shaped cylinders were used as landmark cues (one plain white and the other vertically patterned with four different patterns). The results of the preference test revealed that only the females trained and tested with the plain cylinder spent more time in the area of the pool that corresponded to the landmark than in the distinctive corner of the pool. Finally, Experiment 3 replicated the results of Experiment 2 while eliminating an alternative explanation in terms of differential contrast between the two cylinders and the black curtain

Coulomb-Enhanced Spin-Orbit Splitting: The Missing Piece in the Sr2RhO4 Puzzle

The outstanding discrepancy between the measured and calculated (local-density approximation) Fermi surfaces in the well-characterized, paramagnetic Fermi liquid Sr2RhO4 is resolved by including the spin-orbit coupling and Coulomb repulsion. This results in an effective spin-orbit coupling constant enhanced 2.15 times over the bare value. A simple formalism allows discussion of other systems. For Sr2RhO4, the experimental specific-heat and mass enhancements are found to be 2.2.Comment: 4 pages, 2 figure

Simulation of associative learning with the replaced elements model

Associative learning theories can be categorised according to whether they treat the representation of stimulus compounds in an elemental or configural manner. Since it is clear that a simple elemental approach to stimulus representation is inadequate there have been several attempts to produce more elaborate elemental models. One recent approach, the Replaced Elements Model (Wagner, 2003), reproduces many results that have until recently been uniquely predicted by Pearce’s Configural Theory (Pearce, 1994). Although it is possible to simulate the Replaced Elements Model using “standard” simulation programs the generation of the correct stimulus representation is complex. The current paper describes a method for simulation of the Replaced Elements Model and presents the results of two example simulations that show differential predictions of Replaced Elements and Pearce’s Configural Theor

Online resources and apps to aid self-diagnosis and help seeking in the perinatal period: A descriptive survey of women's experiences.

OBJECTIVE:Assess the role of online resources and apps for women's help seeking and staff's response to concerns in the perinatal period. DESIGN:Online survey. Descriptive analysis of women's use and experiences of digital resources for self-diagnosis and help seeking, drawing on numerical and free-text responses. SETTING:Two tertiary referral centres and one district general hospital in two UK geographic locations. PARTICIPANTS:632 postnatal women, surveyed over a 4 month period. MEASUREMENTS:Women's access to digital devices; frequency and type of health concerns experienced after 22 weeks' gestation; variability in use and experiences of websites/apps; perceptions of staff's response to concerns after help-seeking. FINDINGS:1254 women were approached over a 4-month period; 632 participated (response rate: 50%). Women reported a 'mix and match' blended use of digital resources to both learn about, and self-diagnose/self-triage for potential complications in pregnancy as an adjunct to care provided by maternity staff. Over half the participants experienced concerns about themselves or their baby after 22 weeks. The top concern was fetal movements, reported by 62%. Women used 91 different digital resources to help with understanding and decision-making, in addition to seeking support from family, friends and healthcare professionals. Enabling features of staff responses were identified from free-text responses (n = 292) by women who sought professional help regarding their health concerns, and influencing factors at clinical, organisational and digital level. KEY CONCLUSIONS AND IMPLICATIONS FOR PRACTICE:Online information retrieval and digital self-monitoring is increasingly integral to women's self-care during pregnancy and offers opportunities to support escalation of care and shared decision-making. Further work should assess optimal inclusion of this 'digital work' into clinical consultations

Reaction channel contributions to the helion optical potential

Background: The well-established coupled channel and coupled reaction channel processes contributing to direct reactions make particular contributions to elastic scattering that are absent from local density folding models. Very little has been established concerning the contribution of these processes to the optical model potentials (OMPs) for 3He scattering. For studying such processes, spin-saturated closed shell nuclei such as 16O and 40Ca are particularly suitable target nuclei and the (3He, 4He) reaction is easily handled within conventional reaction theory because it avoids complications such as breakup.Purpose: To establish and characterize the contribution to the 3He-nucleus interaction generated by coupling to neutron pickup (outgoing 4He) channels; also to study the contribution of collective states and identify effects of dynamical nonlocality from these couplings.Methods: Coupled reaction channel (CRC) calculations, including coupling to collective states, will provide the elastic channel S-matrix Sl j resulting from the included processes. Inversion of Sl j will produce the local potential that yields, in a single channel calculation, the elastic scattering observables from the coupled channel calculation. Subtracting the bare potential from the CRC calculations yields a local and l-independent representation of the dynamical polarization potential (DPP). From the DPPs, because of a range of combinations of channel couplings, the influence of dynamically generated nonlocality can be identified.Results: Coupling to 4He channels systematically induces repulsion and absorption in the 3He OMP and also a reduction in the rms radius of the real part. The repulsion and absorption is less for 208Pb than for the lighter target nuclei although the qualitative effects, including the general undularity of the DPPs, are similar for all cases; therefore coupling to these channels cannot be represented by renormalizing folding model potentials. Evidence is presented for substantial dynamical nonlocality of the induced DPPs; for 40Ca this modifies direct reaction angular distributions. The local equivalent DPPs for individual couplings cannot be added to give the overall DPP for the complete set of couplings. For the 208Pb case, channel coupling reduces the reaction cross section although it increases it for 16O, with 40Ca an intermediate case. Conclusions: The DPPs established here strongly challenge the notion that folding models, in particular local density models, provide a satisfactory description of elastic scattering of 3He from nuclei. Coupling to neutron pickup channels induces dynamical nonlocality in the 3He OMP with implications for direct reactions involving 3He. Departures from a smooth radial form for the 3He OMP should be apparent in good fits to suitable elastic scattering data

Parent escalation of care for the deteriorating child in hospital: A health-care improvement study

Objective: To evaluate the implementation of an intervention for parents to escalate care if concerned about their child's clinical condition. Design: Mixed-methods health-care improvement approach guided by the Theoretical Domains Framework. Methods: Implementation of the ‘Calling for Help’ (C4H) intervention was informed by previously identified barriers and facilitators. Evaluation involved audit, review of clinical deterioration incidents, interviews and focus groups. Setting: Australian specialist paediatric hospital. Participants: Convenience sample of 75 parents from inpatient areas during the audit, interviews with ten parents who had expressed concern about their child's clinical condition; five focus groups with 35 ward nurses. Main outcome measures: Parent awareness and utilization of C4H, parent and nurse views of factors influencing implementation. Results: Parent awareness of C4H improved to 35% (25/75). Parent concern was documented prior to 21/174 (12%) clinical deterioration events. All interviewed parents and nurses who participated in focus groups were positive about C4H. Parents preferred to be informed about C4H by nurses, but nurses described this as time-consuming and selectively chose parents who they believed would benefit most. Parents and nurses described frustrations with and trepidation in escalating care. Nurses had used C4H to expedite urgent medical review. Conclusions: There was an improvement in the level of parent awareness of C4H, which was viewed positively by parents and nurses alike. To achieve a high level of parent awareness in a sustainable way, a multifaceted approach is required. Further strategies will be required for parents to feel confident enough to use C4H and to address interprofessional communication barriers