The relevance of sebum composition in the etiopathogeny of acne

Acne vulgaris is an inflammatory disease that develops around the hair follicle. Many are the interconnected etiopathogenic factors involved, among which we can mention the increase in levels of androgen hormones, sebum hypersecretion, follicular hyperkeratosis with microcomedo formation, the proliferation of the bacteria Propionibacterium acnes (P. acnes) and the resulting inflammatory response. The way this bacterial growth occurs and how it is connected with the development of the inflammatory process have been themes of many clinical and experimental trials. Modifications in the sebum composition lead to a greater proliferation and differentiation of keratinocytes that obstruct the follicular ostium and favor the formation of comedones. On the other hand, these modifications alter the follicular hydration and facilitate the proliferation of the P. acnes, which not only produces chemotactic factors but also releases lipase that oxidizes the squalene. The oxidized squalene induces the formation of pro-inflammatory cytokines and boosts the innate immunity of keratinocytes and sebocytes, thus generating the inflammatory process. The aim of this study was to review the literature regarding the new concepts on the pathogenesis of acne. DOI: http://dx.doi.org/10.5281/zenodo.118413

The relevance of sebum composition in the etiopathogeny of acne

Acne vulgaris is an inflammatory disease that develops around the hair follicle. Many are the interconnected etiopathogenic factors involved, among which we can mention the increase in levels of androgen hormones, sebum hypersecretion, follicular hyperkeratosis with microcomedo formation, the proliferation of the bacteria Propionibacterium acnes (P. acnes) and the resulting inflammatory response. The way this bacterial growth occurs and how it is connected with the development of the inflammatory process have been themes of many clinical and experimental trials. Modifications in the sebum composition lead to a greater proliferation and differentiation of keratinocytes that obstruct the follicular ostium and favor the formation of comedones. On the other hand, these modifications alter the follicular hydration and facilitate the proliferation of the P. acnes, which not only produces chemotactic factors but also releases lipase that oxidizes the squalene. The oxidized squalene induces the formation of pro-inflammatory cytokines and boosts the innate immunity of keratinocytes and sebocytes, thus generating the inflammatory process. The aim of this study was to review the literature regarding the new concepts on the pathogenesis of acne. DOI: http://dx.doi.org/10.5281/zenodo.118413

Superficial technique for tear trough filling with cohesive polydensified matrix hyaluronic acid

Introduction: Deep tear troughs create unaesthetic hollows that often worsen the color alteration and aspect of dark undereye circles, thus giving an aged and tired appearance to the eyes, even in younger individuals. The use of dermal fillers for the restoration of volume loss in the area, with a wide variety of products and techniques, has been the most suitable treatment. Aim: Description and evaluation of the superficial intradermal injection technique for tear trough filling using cohesive polydensified matrix hyaluronic acid. Materials and Methods: 120 patients from Faculdade de Medicina do ABC’s Cosmetic Dermatology Sector and a private practice treated between the years 2011 and 2016. Results: All the patients rated the treatment result as good or very good. No important or long-lasting adverse effects were reported; the Tyndall effect was not observed either. Conclusion: The superficial technique is an easy and safe method to treat the tear trough deformity, with high rates of good aesthetic results. DOI: http://dx.doi.org/10.5281/zenodo.427243

Implantes em vitiligo

BV UNIFESP: Teses e dissertaçõe

Terapia despigmentante para vitiligo generalizado com solução tópica de fenol 88% Depigmentation therapy for generalized vitiligo with topical 88% phenol solution

Os autores relatam um caso de vitiligo generalizado com áreas normocrômicas residuais tratadas com sucesso com solução de fenol 88%.<br>Authors relate a case of generalized vitiligo with residual normochromic patches succesfully treated with 88% solution of phenol

Uso de esponja cirúrgica para curativo compressivo de enxerto cutâneo Surgical sponge as a pressure dressing for skin grafts

O enxerto cutâneo é um modo efetivo para restaurar feridas. O curativo compressivo é importante para a vitalidade do enxerto. Os autores observaram que o uso de esponja cirúrgica como curativo compressivo em enxertos cutâneos é factível e aconselhável.<br>Cutaneous graft is an effective way to treat wounds. A pressure dressing is important for the vitality of such grafts. We have observed that the use of surgical sponge as a pressure dressing on cutaneous grafts is feasible and recommend its use