Towards Trustworthy Healthcare AI: Attention-Based Feature Learning for COVID-19 Screening With Chest Radiography

Building AI models with trustworthiness is important especially in regulated areas such as healthcare. In tackling COVID-19, previous work uses convolutional neural networks as the backbone architecture, which has shown to be prone to over-caution and overconfidence in making decisions, rendering them less trustworthy -- a crucial flaw in the context of medical imaging. In this study, we propose a feature learning approach using Vision Transformers, which use an attention-based mechanism, and examine the representation learning capability of Transformers as a new backbone architecture for medical imaging. Through the task of classifying COVID-19 chest radiographs, we investigate into whether generalization capabilities benefit solely from Vision Transformers' architectural advances. Quantitative and qualitative evaluations are conducted on the trustworthiness of the models, through the use of "trust score" computation and a visual explainability technique. We conclude that the attention-based feature learning approach is promising in building trustworthy deep learning models for healthcare.Comment: Accepted to 39th International Conference on Machine Learning, Workshop on Healthcare AI and COVID-1

PKSB1740-517: An ALMA view of the cold gas feeding a distant interacting young radio galaxy

Cold neutral gas is a key ingredient for growing the stellar and central black hole mass in galaxies throughout cosmic history. We have used the Atacama Large Millimetre Array (ALMA) to detect a rare example of redshifted $^{12}$CO(2-1) absorption in PKS B1740-517, a young ($t \sim 1.6 \times 10^{3}$ yr) and luminous ($L_{\rm 5 GHz} \sim 6.6 \times 10^{43}$ erg s$^{-1}$ ) radio galaxy at $z = 0.44$ that is undergoing a tidal interaction with at least one lower-mass companion. The coincident HI 21-cm and molecular absorption have very similar line profiles and reveal a reservoir of cold gas ($M_{\rm gas} \sim 10^{7} - 10^{8}$ M$_{\odot}$), likely distributed in a disc or ring within a few kiloparsecs of the nucleus. A separate HI component is kinematically distinct and has a very narrow line width ($\Delta{v}_{\rm FWHM} \lesssim 5$ km s$^{-1}$), consistent with a single diffuse cloud of cold ($T_{\rm k} \sim 100$ K) atomic gas. The $^{12}$CO(2-1) absorption is not associated with this component, which suggests that the cloud is either much smaller than 100 pc along our sight-line and/or located in low-metallicity gas that was possibly tidally stripped from the companion. We argue that the gas reservoir in PKS B1740-517 may have accreted onto the host galaxy $\sim$50 Myr before the young radio AGN was triggered, but has only recently reached the nucleus. This is consistent with the paradigm that powerful luminous radio galaxies are triggered by minor mergers and interactions with low-mass satellites and represent a brief, possibly recurrent, active phase in the life cycle of massive early type galaxies.Comment: 15 pages, 7 figures, accepted for publication in MNRA

A novel expression platform for the production of diabetes-associated autoantigen human glutamic acid decarboxylase (hGAD65)

<p>Abstract</p> <p>Background</p> <p>Human glutamic acid decarboxylase 65 (hGAD65) is a key autoantigen in type 1 diabetes, having much potential as an important marker for the prediction and diagnosis of type 1 diabetes, and for the development of novel antigen-specific therapies for the treatment of type 1 diabetes. However, recombinant production of hGAD65 using conventional bacterial or mammalian cell culture-based expression systems or nuclear transformed plants is limited by low yield and low efficiency. Chloroplast transformation of the unicellular eukaryotic alga <it>Chlamydomonas reinhardtii </it>may offer a potential solution.</p> <p>Results</p> <p>A DNA cassette encoding full-length <it>hGAD65</it>, under the control of the <it>C. reinhardtii </it>chloroplast <it>rbc</it>L promoter and 5'- and 3'-UTRs, was constructed and introduced into the chloroplast genome of <it>C. reinhardtii </it>by particle bombardment. Integration of <it>hGAD65 </it>DNA into the algal chloroplast genome was confirmed by PCR. Transcriptional expression of <it>hGAD65 </it>was demonstrated by RT-PCR. Immunoblotting verified the expression and accumulation of the recombinant protein. The antigenicity of algal-derived hGAD65 was demonstrated with its immunoreactivity to diabetic sera by ELISA and by its ability to induce proliferation of spleen cells from NOD mice. Recombinant hGAD65 accumulated in transgenic algae, accounts for approximately 0.25–0.3% of its total soluble protein.</p> <p>Conclusion</p> <p>Our results demonstrate the potential value of <it>C. reinhardtii </it>chloroplasts as a novel platform for rapid mass production of immunologically active hGAD65. This demonstration opens the future possibility for using algal chloroplasts as novel bioreactors for the production of many other biologically active mammalian therapeutic proteins.</p

How effective is stretching in maintaining range of movement for children with cerebral palsy?

YesBackground: Cerebral Palsy (CP) is the most common childhood disorder affecting four percent of children born in the UK. It is common for children with CP to have reduced range of movement (ROM) due to spasticity and contractures. Stretching is commonly used in physiotherapy programmes to manage this. Aim: This critical review aims to evaluate the evidence base behind the use of stretching for children with CP. Methods: A systematic literature search of AMED, CINAHL, MEDLINE and Cochrane Library Trials was conducted. Returned searches were assessed against strict criteria according to a predefined PICOS (Population, Intervention, Comparison, Outcome, Study). These studies were then critically appraised to assess the validity, reliability and clinical relevance. Findings: There is evidence supporting the use of stretching in children with CP. However there is also some evidence to suggest very little or no positive change. All of the included studies have methodological limitations, which questions the validity of the results. Conclusions/Recommendations: The research suggests some positive outcomes for the use of stretching in CP, studies that did not find positive outcomes found no adverse effects; however further research in the area is required to validate the effectiveness of stretching to maintain ROM in children with CP

The Spheres & Shield Maze Task: A virtual reality serious game for the assessment of risk taking in decision making

[EN] Risk taking (RT) is an essential component in decision-making process that depicts the propensity to make risky decisions. RT assessment has traditionally focused on self-report questionnaires. These classical tools have shown clear distance from real-life responses. Behavioral tasks assess human behavior with more fidelity, but still show some limitations related to transferability. A way to overcome these constraints is to take advantage from virtual reality (VR), to recreate real-simulated situations that might arise from performance-based assessments, supporting RT research. This article presents results of a pilot study in which 41 individuals explored a gamified VR environment: the Spheres & Shield Maze Task (SSMT). By eliciting implicit behavioral measures, we found relationships between scores obtained in the SSMT and self-reported risk-related constructs, as engagement in risky behaviors and marijuana consumption. We conclude that decontextualized Virtual Reality Serious Games are appropriate to assess RT, since they could be used as a cross-disciplinary tool to assess individuals' capabilities under the stealth assessment paradigm.This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness funded projects "Advanced Therapeutic Tools for Mental Health'' (DPI2016-77396-R), and "Assessment and Training on Decision Making in Risk Environments'' (RTC-2017-6523-6) (MINECO/AEI/FEDER,UE) and by the Generalitat Valenciana funded project "Rebrand'' (PROMETEU/2019/105).Juan-Ripoll, CD.; Soler-Domínguez, JL.; Chicchi-Giglioli, IA.; Contero, M.; Alcañiz Raya, ML. (2020). The Spheres & Shield Maze Task: A virtual reality serious game for the assessment of risk taking in decision making. Cyberpsychology Behavior and Social Networking. 23(11):773-781. https://doi.org/10.1089/cyber.2019.0761S7737812311Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R. (2005). The Iowa Gambling Task and the somatic marker hypothesis: some questions and answers. Trends in Cognitive Sciences, 9(4), 159-162. doi:10.1016/j.tics.2005.02.002Krain, A. L., Wilson, A. M., Arbuckle, R., Castellanos, F. X., & Milham, M. P. (2006). Distinct neural mechanisms of risk and ambiguity: A meta-analysis of decision-making. NeuroImage, 32(1), 477-484. doi:10.1016/j.neuroimage.2006.02.047Einhorn, H. J. (1970). The use of nonlinear, noncompensatory models in decision making. Psychological Bulletin, 73(3), 221-230. doi:10.1037/h0028695Figner, B., & Weber, E. U. (2011). Who Takes Risks When and Why? Current Directions in Psychological Science, 20(4), 211-216. doi:10.1177/0963721411415790Endsley, M. R., & Garland, D. J. (Eds.). (2000). Situation Awareness Analysis and Measurement. doi:10.1201/b12461Lauriola, M., & Levin, I. P. (2001). Personality traits and risky decision-making in a controlled experimental task: an exploratory study. Personality and Individual Differences, 31(2), 215-226. doi:10.1016/s0191-8869(00)00130-6Rundmo, T. (1996). Associations between risk perception and safety. Safety Science, 24(3), 197-209. doi:10.1016/s0925-7535(97)00038-6Zuckerman, M., & Kuhlman, D. M. (2000). Personality and Risk‐Taking: Common Bisocial Factors. Journal of Personality, 68(6), 999-1029. doi:10.1111/1467-6494.00124Dahlen, E. R., Martin, R. C., Ragan, K., & Kuhlman, M. M. (2005). Driving anger, sensation seeking, impulsiveness, and boredom proneness in the prediction of unsafe driving. Accident Analysis & Prevention, 37(2), 341-348. doi:10.1016/j.aap.2004.10.006Donohew, L., Zimmerman, R., Cupp, P. S., Novak, S., Colon, S., & Abell, R. (2000). Sensation seeking, impulsive decision-making, and risky sex: implications for risk-taking and design of interventions. Personality and Individual Differences, 28(6), 1079-1091. doi:10.1016/s0191-8869(99)00158-0Moreno, M., Estevez, A. F., Zaldivar, F., Montes, J. M. G., Gutiérrez-Ferre, V. E., Esteban, L., … Flores, P. (2012). Impulsivity differences in recreational cannabis users and binge drinkers in a university population. Drug and Alcohol Dependence, 124(3), 355-362. doi:10.1016/j.drugalcdep.2012.02.011Dvorak, R. D., & Day, A. M. (2014). Marijuana and self-regulation: Examining likelihood and intensity of use and problems. Addictive Behaviors, 39(3), 709-712. doi:10.1016/j.addbeh.2013.11.001Trocki, K. F., Drabble, L. A., & Midanik, L. T. (2009). Tobacco, marijuana, and sensation seeking: Comparisons across gay, lesbian, bisexual, and heterosexual groups. Psychology of Addictive Behaviors, 23(4), 620-631. doi:10.1037/a0017334Ames, S. L., Zogg, J. B., & Stacy, A. W. (2002). Implicit cognition, sensation seeking, marijuana use and driving behavior among drug offenders. Personality and Individual Differences, 33(7), 1055-1072. doi:10.1016/s0191-8869(01)00212-4Highhouse, S., Nye, C. D., Zhang, D. C., & Rada, T. B. (2016). Structure of the Dospert: Is There Evidence for a General Risk Factor? Journal of Behavioral Decision Making, 30(2), 400-406. doi:10.1002/bdm.1953Jackson, D. N., Hourany, L., & Vidmar, N. J. (1972). A four-dimensional interpretation of risk taking1. Journal of Personality, 40(3), 483-501. doi:10.1111/j.1467-6494.1972.tb00075.xSkeel, R. L., Neudecker, J., Pilarski, C., & Pytlak, K. (2007). The utility of personality variables and behaviorally-based measures in the prediction of risk-taking behavior. Personality and Individual Differences, 43(1), 203-214. doi:10.1016/j.paid.2006.11.025Horvath, P., & Zuckerman, M. (1993). Sensation seeking, risk appraisal, and risky behavior. Personality and Individual Differences, 14(1), 41-52. doi:10.1016/0191-8869(93)90173-zLejuez, C. W., Aklin, W. M., Zvolensky, M. J., & Pedulla, C. M. (2003). Evaluation of the Balloon Analogue Risk Task (BART) as a predictor of adolescent real-world risk-taking behaviours. Journal of Adolescence, 26(4), 475-479. doi:10.1016/s0140-1971(03)00036-8Verhulst, N., De Keyser, A., Gustafsson, A., Shams, P., & Van Vaerenbergh, Y. (2019). Neuroscience in service research: an overview and discussion of its possibilities. Journal of Service Management, 30(5), 621-649. doi:10.1108/josm-05-2019-0135de-Juan-Ripoll, C., Soler-Domínguez, J. L., Guixeres, J., Contero, M., Álvarez Gutiérrez, N., & Alcañiz, M. (2018). Virtual Reality as a New Approach for Risk Taking Assessment. Frontiers in Psychology, 9. doi:10.3389/fpsyg.2018.02532Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition, 50(1-3), 7-15. doi:10.1016/0010-0277(94)90018-3Bottari, C., Dassa, C., Rainville, C., & Dutil, É. (2009). The factorial validity and internal consistency of the Instrumental Activities of Daily Living Profile in individuals with a traumatic brain injury. Neuropsychological Rehabilitation, 19(2), 177-207. doi:10.1080/09602010802188435Verschoor, A., D’Exelle, B., & Perez-Viana, B. (2016). Lab and life: Does risky choice behaviour observed in experiments reflect that in the real world? Journal of Economic Behavior & Organization, 128, 134-148. doi:10.1016/j.jebo.2016.05.009Tarr, M. J., & Warren, W. H. (2002). Virtual reality in behavioral neuroscience and beyond. Nature Neuroscience, 5(S11), 1089-1092. doi:10.1038/nn948Alcañiz, M., Rey, B., Tembl, J., & Parkhutik, V. (2009). A Neuroscience Approach to Virtual Reality Experience Using Transcranial Doppler Monitoring. Presence: Teleoperators and Virtual Environments, 18(2), 97-111. doi:10.1162/pres.18.2.97Chittaro, L., & Ranon, R. (2009). Serious Games for Training Occupants of a Building in Personal Fire Safety Skills. 2009 Conference in Games and Virtual Worlds for Serious Applications. doi:10.1109/vs-games.2009.8Lovreglio, R., Gonzalez, V., Amor, R., Spearpoint, M., Thomas, J., Trotter, M., & Sacks, R. (2017). The Need for Enhancing Earthquake Evacuee Safety by Using Virtual Reality Serious Games. Lean and Computing in Construction Congress - Volume 1: Proceedings of the Joint Conference on Computing in Construction. doi:10.24928/jc3-2017/0058Rizzo, A. A., Bowerly, T., Buckwalter, J. G., Klimchuk, D., Mitura, R., & Parsons, T. D. (2009). A Virtual Reality Scenario for All Seasons:The Virtual Classroom. CNS Spectrums, 11(1), 35-44. doi:10.1017/s1092852900024196Chicchi Giglioli, I. A., de Juan Ripoll, C., Parra, E., & Alcañiz Raya, M. (2019). Are 3D virtual environments better than 2D interfaces in serious games performance? An explorative study for the assessment of executive functions. Applied Neuropsychology: Adult, 28(2), 148-157. doi:10.1080/23279095.2019.1607735Huang, H.-M., Rauch, U., & Liaw, S.-S. (2010). Investigating learners’ attitudes toward virtual reality learning environments: Based on a constructivist approach. Computers & Education, 55(3), 1171-1182. doi:10.1016/j.compedu.2010.05.014Dalgarno, B., & Lee, M. J. W. (2009). What are the learning affordances of 3-D virtual environments? British Journal of Educational Technology, 41(1), 10-32. doi:10.1111/j.1467-8535.2009.01038.xFowler, C. (2014). Virtual reality and learning: Where is the pedagogy? British Journal of Educational Technology, 46(2), 412-422. doi:10.1111/bjet.12135Zuckerman, M., Kolin, E. A., Price, L., & Zoob, I. (1964). Development of a sensation-seeking scale. Journal of Consulting Psychology, 28(6), 477-482. doi:10.1037/h0040995Patton, J. H., Stanford, M. S., & Barratt, E. S. (1995). Factor structure of the barratt impulsiveness scale. Journal of Clinical Psychology, 51(6), 768-774. doi:10.1002/1097-4679(199511)51:63.0.co;2-1So, R. H. Y., Lo, W. T., & Ho, A. T. K. (2001). Effects of Navigation Speed on Motion Sickness Caused by an Immersive Virtual Environment. Human Factors: The Journal of the Human Factors and Ergonomics Society, 43(3), 452-461. doi:10.1518/001872001775898223Zuckerman, M. (2008). Sensation Seeking. The International Encyclopedia of Communication. doi:10.1002/9781405186407.wbiecs029Orlebeke, J. F., Van Der Molen, M. W., Dolan, C., & Stoffels, E. J. (1990). The additive factor logic applied to the personality trait disinhibition. Personality and Individual Differences, 11(6), 553-558. doi:10.1016/0191-8869(90)90037-rPopham, L. E., Kennison, S. M., & Bradley, K. I. (2011). Ageism, Sensation-Seeking, and Risk-Taking Behavior in Young Adults. Current Psychology, 30(2), 184-193. doi:10.1007/s12144-011-9107-0Roberti, J. W. (2004). A review of behavioral and biological correlates of sensation seeking. Journal of Research in Personality, 38(3), 256-279. doi:10.1016/s0092-6566(03)00067-9Zuckerman, M., Eysenck, S. B., & Eysenck, H. J. (1978). Sensation seeking in England and America: Cross-cultural, age, and sex comparisons. Journal of Consulting and Clinical Psychology, 46(1), 139-149. doi:10.1037/0022-006x.46.1.139Television campaigns and adolescent marijuana use: tests of sensation seeking targeting. (2001). American Journal of Public Health, 91(2), 292-296. doi:10.2105/ajph.91.2.292Barry, D., & Petry, N. M. (2008). Predictors of decision-making on the Iowa Gambling Task: Independent effects of lifetime history of substance use disorders and performance on the Trail Making Test. Brain and Cognition, 66(3), 243-252. doi:10.1016/j.bandc.2007.09.00

A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression

Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are unknown. Here we report that a long NAT (Mm-antiNos1 RNA) complementary to mRNA encoding the neuronal isoform of nitric oxide synthase (Nos1) is expressed in the mouse brain and is transcribed from the non-template strand of the Nos1 locus. Nos1 produces nitric oxide (NO), a major signaling molecule in the CNS implicated in many important functions including neuronal differentiation and memory formation. We show that the newly discovered NAT negatively regulates Nos1 gene expression. Moreover, our quantitative studies of the temporal expression profiles of Mm-antiNos1 RNA in the mouse brain during embryonic development and postnatal life indicate that it may be involved in the regulation of NO-dependent neurogenesis

Development of aggression subtypes from childhood to adolescence:a group-based multi-trajectory modelling perspective

The persistence of elevated subtypes of aggression beginning in childhood have been associated with long-term maladaptive outcomes. Yet it remains unclear to what extent there are clusters of individuals following similar developmental trajectories across forms (i.e., physical and indirect) and functions (i.e., proactive and reactive) of aggression. We aimed to identify groups of children with distinct profiles of the joint development of forms and functions of aggression and to identify risk factors for group membership. A sample of 787 children was followed from birth to adolescence. Parent and teacher reports, and standardised assessments were used to measure two forms and two functions of aggressive behaviour, between six and 13 years of age along with preceding child, maternal, and family-level risk-factors. Analyses were conducted using a group-based multi-trajectory modelling approach. Five trajectory groups emerged: non-aggressors, low-stable, moderate-engagers, high-desisting, and high-chronic. Coercive parenting increased membership risk in the moderate-engagers and high-chronic groups. Lower maternal IQ increased membership risk in both high-desisting and high-chronic groups, whereas maternal depression increased membership risk in the high-desisting group only. Never being breastfed increased membership risk in the moderate-engagers group. Boys were at greater risk for belonging to groups displaying elevated aggression. Individuals with chronic aggression problems use all subtypes of aggression. Risk factors suggest that prevention programs should start early in life and target mothers with lower IQ. Strategies to deal with maternal depression and enhance positive parenting while replacing coercive parenting tactics should be highlighted in programming efforts

Uterine artery pseudoaneurysm requiring embolization in pregnancy: a case report and review of the literature.

Background: Uterine Artery Pseudoaneurysm is a rare cause of pelvic pain and haemorrhage in pregnancy. It should be considered in the differential diagnosis of pregnant women presenting with abdominal pain and is readily diagnosed by colour Doppler ultrasound. If left untreated, they may bleed into the peritoneum causing severe pain and haemorrhagic shock and may progress to maternal and fetal death. Case presentation: We describe a case of a woman presenting with severe right iliac fossa pain at 26 weeks gestation attributed to a right uterine artery pseudoaneurysm diagnosed on duplex ultrasound which was successfully treated by uterine artery embolization at 28 weeks gestation without complication to the fetus. Conclusion: Uterine artery embolization appears to be a safe and effective method to treat pseudoaneurysm during pregnancy without compromising uteroplacental perfusion

Associations between fruit and vegetable intake, leisure-time physical activity, sitting time and self-rated health among older adults : cross-sectional data from the WELL study

BackgroundLifestyle behaviours, such as healthy diet, physical activity and sedentary behaviour, are key elements of healthy ageing and important modifiable risk factors in the prevention of chronic diseases. Little is known about the relationship between these behaviours in older adults. The purpose of this study was to explore the relationship between fruit and vegetable (F&amp;V) intake, leisure-time physical activity (LTPA) and sitting time (ST), and their association with self-rated health in older adults.MethodsThis cross-sectional study comprised 3,644 older adults (48% men) aged 55-65 years, who participated in the Wellbeing, Eating and Exercise for a Long Life (&quot;WELL&quot;) study. Respondents completed a postal survey about their health and their eating and physical activity behaviours in 2010 (38% response rate). Spearman\u27s coefficient (rho) was used to evaluate the relationship between F&amp;V intake, LTPA and ST. Their individual and shared associations with self-rated health were examined using ordinal logistic regression models, stratified by sex and adjusted for confounders (BMI, smoking, long-term illness and socio-demographic characteristics).ResultsThe correlations between F&amp;V intake, LTPA and ST were low. F&amp;V intake and LTPA were positively associated with self-rated health. Each additional serving of F&amp;V or MET-hour of LTPA were associated with approximately 10% higher likelihood of reporting health as good or better among women and men. The association between ST and self-rated health was not significant in the multivariate analysis. A significant interaction was found (ST*F&amp;V intake). The effect of F&amp;V intake on self-rated health increased with increasing ST in women, whereas the effect decreased with increasing ST in men.ConclusionThis study contributes to the scarce literature related to lifestyle behaviours and their association with health indicators among older adults. The findings suggest that a modest increase in F&amp;V intake, or LTPA could have a marked effect on the health of older adults. Further research is needed to fully understand the correlates and determinants of lifestyle behaviours, particularly sitting time, in this age group

Dairy consumption and cardiometabolic diseases: systematic review and updated meta-analyses of prospective cohort studies

Purpose of Review Dairy products contain both beneficial and harmful nutrients in relation to cardiometabolic diseases. Here, we provide the latest scientific evidence regarding the relationship between dairy products and cardiometabolic diseases by reviewing the literature and updating meta-analyses of observational studies. Recent Findings We updated our previous meta-analyses of cohort studies on type 2 diabetes, coronary heart disease (CHD), and stroke with nine studies and confirmed previous results. Total dairy and low-fat dairy (per 200 g/d) were inversely associated with a 3–4% lower risk of diabetes. Yogurt was non-linearly inversely associatedwith diabetes (RR = 0.86, 95%CI: 0.83–0.90 at 80 g/ d). Total dairy and milk were not associated with CHD (RR~1.0). An increment of 200 g of daily milk intake was associated with an 8% lower risk of stroke. Summary The latest scientific evidence confirmed neutral or beneficial associations between dairy products and risk of cardiometabolic diseases