67 research outputs found
Controllable Entanglement of Lights in a Five-Level System
We analyze the nonlinear optical response of a five-level system under a
novel configuration of electro-magnetically induced transparency. We show that
a giant Kerr nonlinearity with a relatively large cross-phase modulation
coefficient that occurs in such system may be used to produce an efficient
photon-photon entanglement. We demonstrate that such photon-photon entanglement
is practically controllable and hence facilitates promising applications in
quantum information and computation.Comment: 13 pages, 4 figures, 1 column. We have added a section in which the
distortion of pulses due to the dispersion is considere
Hybrid Mechanical Systems
We discuss hybrid systems in which a mechanical oscillator is coupled to
another (microscopic) quantum system, such as trapped atoms or ions,
solid-state spin qubits, or superconducting devices. We summarize and compare
different coupling schemes and describe first experimental implementations.
Hybrid mechanical systems enable new approaches to quantum control of
mechanical objects, precision sensing, and quantum information processing.Comment: To cite this review, please refer to the published book chapter (see
Journal-ref and DOI). This v2 corresponds to the published versio
A Mighty Small Heart: The Cardiac Proteome of Adult Drosophila melanogaster
Drosophila melanogaster is emerging as a powerful model system
for the study of cardiac disease. Establishing peptide and protein maps of the
Drosophila heart is central to implementation of protein
network studies that will allow us to assess the hallmarks of
Drosophila heart pathogenesis and gauge the degree of
conservation with human disease mechanisms on a systems level. Using a
gel-LC-MS/MS approach, we identified 1228 protein clusters from 145 dissected
adult fly hearts. Contractile, cytostructural and mitochondrial proteins were
most abundant consistent with electron micrographs of the
Drosophila cardiac tube. Functional/Ontological enrichment
analysis further showed that proteins involved in glycolysis,
Ca2+-binding, redox, and G-protein signaling, among other
processes, are also over-represented. Comparison with a mouse heart proteome
revealed conservation at the level of molecular function, biological processes
and cellular components. The subsisting peptidome encompassed 5169 distinct
heart-associated peptides, of which 1293 (25%) had not been identified in
a recent Drosophila peptide compendium. PeptideClassifier
analysis was further used to map peptides to specific gene-models. 1872 peptides
provide valuable information about protein isoform groups whereas a further 3112
uniquely identify specific protein isoforms and may be used as a
heart-associated peptide resource for quantitative proteomic approaches based on
multiple-reaction monitoring. In summary, identification of
excitation-contraction protein landmarks, orthologues of proteins associated
with cardiovascular defects, and conservation of protein ontologies, provides
testimony to the heart-like character of the Drosophila cardiac
tube and to the utility of proteomics as a complement to the power of genetics
in this growing model of human heart disease
AEDGE: Atomic Experiment for Dark Matter and Gravity Exploration in Space
We propose in this White Paper a concept for a space experiment using cold
atoms to search for ultra-light dark matter, and to detect gravitational waves
in the frequency range between the most sensitive ranges of LISA and the
terrestrial LIGO/Virgo/KAGRA/INDIGO experiments. This interdisciplinary
experiment, called Atomic Experiment for Dark Matter and Gravity Exploration
(AEDGE), will also complement other planned searches for dark matter, and
exploit synergies with other gravitational wave detectors. We give examples of
the extended range of sensitivity to ultra-light dark matter offered by AEDGE,
and how its gravitational-wave measurements could explore the assembly of
super-massive black holes, first-order phase transitions in the early universe
and cosmic strings. AEDGE will be based upon technologies now being developed
for terrestrial experiments using cold atoms, and will benefit from the space
experience obtained with, e.g., LISA and cold atom experiments in microgravity.
This paper is based on a submission (v1) in response to the Call for White
Papers for the Voyage 2050 long-term plan in the ESA Science Programme. ESA
limited the number of White Paper authors to 30. However, in this version (v2)
we have welcomed as supporting authors participants in the Workshop on Atomic
Experiments for Dark Matter and Gravity Exploration held at CERN: ({\tt
https://indico.cern.ch/event/830432/}), as well as other interested scientists,
and have incorporated additional material
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially visceral], glucose intolerance, endothelial dysfunction), each of which is an independent risk factor for cardiovascular disease (CVD). Multiple prospective studies have documented an association between insulin resistance and accelerated CVD in patients with type 2 diabetes, as well as in non-diabetic individuals. The molecular causes of insulin resistance, i.e. impaired insulin signalling through the phosphoinositol-3 kinase pathway with intact signalling through the mitogen-activated protein kinase pathway, are responsible for the impairment in insulin-stimulated glucose metabolism and contribute to the accelerated rate of CVD in type 2 diabetes patients. The current epidemic of diabetes is being driven by the obesity epidemic, which represents a state of tissue fat overload. Accumulation of toxic lipid metabolites (fatty acyl CoA, diacylglycerol, ceramide) in muscle, liver, adipocytes, beta cells and arterial tissues contributes to insulin resistance, beta cell dysfunction and accelerated atherosclerosis, respectively, in type 2 diabetes. Treatment with thiazolidinediones mobilises fat out of tissues, leading to enhanced insulin sensitivity, improved beta cell function and decreased atherogenesis. Insulin resistance and lipotoxicity represent the missing links (beyond the classical cardiovascular risk factors) that help explain the accelerated rate of CVD in type 2 diabetic patients
Towards variance-matrix characterization of complementarity relations in a continuous variable system
Tomographic characterisation of correlations in a photonic tripartite state
Starting from a four-partite photonic hyper-entangled Dicke resource, we
report the full tomographic characterization of three-, two-, and one-qubit
states obtained by projecting out part of the computational register. The
reduced states thus obtained correspond to fidelities with the expected states
larger than 87%, therefore certifying the faithfulness of the
entanglement-sharing structure within the original four-qubit resource. The
high quality of the reduced three-qubit state allows for the experimental
verification of the Koashi-Winter relation for the monogamy of correlations
within a tripartite state. We show that, by exploiting the symmetries of the
three-qubit state obtained upon projection over the four-qubit Dicke resource,
such relation can be experimentally fully characterized using only 5
measurement settings. We highlight the limitations of such approach and sketch
an experimentally-oriented way to overcome them.Comment: 13 pages, 5 figure
Odorant receptor gene expression changes during the parr-smolt transformation in Atlantic salmon
- …