5 research outputs found
Effect of selenium fertilization on the accumulation of cadmium and lead in rice plants
- Author
- A Fargasova
- CA Grant
- CB Allan
- D Caussy
- DR Juberg
- EK Silbergeld
- F Capdevila
- FM Fordyce
- Gareth John Norton
- GJ Taylor
- GL Duan
- Guilan Duan
- H Deng
- H Hartikainen
- I Murata
- JG Liu
- JK Yoon
- L Lin
- L Marchiol
- M Kumar
- M Srivastava
- M Zembala
- MA Francek
- MH Bhattacharyya
- MJ Hawkesford
- MJ McLaughlin
- MJ Small
- ML Otte
- MP Rayman
- MS Taspinar
- N Yamagata
- NS Bolan
- O Gotsis
- P Zhuang
- PN Williams
- PN Williams
- PP He
- QW Yang
- R Badiello
- RW Feng
- S Clemens
- S Verma
- T Kuboi
- XB Zhou
- XY Tang
- Yanchao Huang
- Ying Hu
- Yunxia Liu
- Z Pedrero
- ZW Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
MENTAL MODELS ABOUT SEISMIC EFFECTS: STUDENTS’ PROFILE BASED COMPARATIVE ANALYSIS
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Potentially toxic elements in urban soils: source apportionment and contamination assessment
- Author
- A Argyraki
- A Baharifar
- A Cachada
- A Christoforidis
- A Kabata-Pendias
- A Kabata-Pendias
- A Okorie
- A RodrĂguez-Seijo
- A Turner
- AA Odewande
- AA Sepahi
- AJ Fernandez-Espinosa
- Andrew S. Hursthouse
- AP Davis
- AW Rate
- B Wei
- British Standard Institution
- C Costa
- C Kuang
- C MicĂł
- C Patinha
- C Reimann
- C Su
- C Zhang
- CC Johnson
- CS Wong
- CS-L Lee
- D Beers Van
- D Cicchella
- DS Manta
- E Callender
- E Liu
- E Smolders
- E Solgi
- F Ajmone-Marsan
- F Amato
- FM Fordyce
- G Abrahim
- G Kisku
- G MacKinnon
- G Qingjie
- G Shi
- GL Yuan
- H Bohemen Van
- H Cheng
- H Yongming
- HG Zechmeister
- HW Mielke
- I Galušková
- I Othman
- I Yesilonis
- J Acosta
- J Sims
- J Sternbeck
- JA Acosta
- JA Carrero
- JR Dean
- K Adachi
- K Ljung
- L Giusti
- L Poggio
- M Andersson
- M Biasioli
- M Guney
- M Romic
- M Saeedi
- M Woszczyk
- M Yeganeh
- MA Francek
- Mahsa Tashakor
- MD Hays
- MJ McLaughlin
- Neda Sharifi Soltani
- NS Duzgoren-Aydin
- P Abrahams
- P Peltola
- P Tume
- R Tang
- RA Sutherland
- RG Mitchell
- S Charlesworth
- S Maas
- S Norra
- S Shojaeimehr
- Soroush Modabberi
- ST Pickett
- TB Chen
- TTT Dung
- U Pietrzak
- VP Salonen
- W Cannon
- WM Lau
- X Li
- X Lu
- X Xia
- Y Hu
- Y-M Zheng
- Z Lin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Edoxaban versus warfarin in patients with atrial fibrillation
- Author
- Abdullakutty J
- Abi-Mansour P
- Abril SB
- Accini J
- Accini M
- Acikel M
- Acikel M
- Adachi C
- Adams K
- Adams K
- Adamus J
- Adler J
- Adler P
- Agarwal D
- Aggarwal R
- Aggarwal R
- Agirov M
- Agraou B
- Ahmad A
- Ahmadpour H
- Ahuad Guerrero R
- Ajioka M
- Akhter F
- Akihisa U
- Akilli H
- Al-Maliky T
- Al-Zoebi A
- Albert L. Waldo
- Albisu J
- Albulescu P
- Alexander J
- Alexandrova L
- Alexopoulos D
- Alexopoulos D
- Alhakim M
- Aliyar P
- Allall O
- Allison J
- Allman J
- Almaraz SP
- Almeida A
- Almeida M
- Almquist A
- Aloni I
- Alsheikh T
- Altonen D
- Alvarez C
- Alvarez M
- Alvarez RF
- Amarenco P
- Amato Vincenzo de Paola A
- Ambrovic I
- Ambrovicova V
- Ameriso P
- Ameriso S
- Amin K
- Amin M
- Amuchastegui M
- Anciu M
- Anderson C
- Anderson J
- Anderson J
- Andersson R
- Andor M
- Andrade Lotufo P
- Andresen T
- Andrews A
- Angel J
- Anscombe R
- Anthony A
- Antle S
- Antman EM
- Antman EM
- Antonino M
- Anzai T
- Apetrei E
- Apostolovic S
- Appelros P
- Aquino M
- Arakawa S
- AraĂşjo E
- Archibald J
- Arcocha Torres M
- Ardelean A
- Arfaoui M
- Arias J
- Armas BH
- Arneja J
- Arnold T
- Arora T
- Arora V
- Arouni A
- Arrieta M
- Arroyave C
- Arstall M
- Arutyunov G
- Asakura H
- Asensio A
- Astier L
- Ata N
- Ata N
- Atar D
- Atar D
- Atar S
- Atie J
- Atkinson C
- Attanti S
- Aude Y
- Augusto Alves da Costa F
- Aull L
- Ault S
- Ausperger KM
- Avellar K
- Averett P
- Avery D
- Avila H
- Avvaru G
- Awasty V
- Awtry E
- Ayasse D
- Ayau Milla O
- Ayesu K
- Aylward P
- Azhdari M
- Azua MG
- Babbar A
- Babbolin M
- Babilonia N
- Babilonia N
- Babu P
- Babu R
- Babuty D
- Badenhorst J
- Badila E
- Bae HJ
- Bagatin J
- Bagby J
- Bai F
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- Bakliza Z
- Balboa W
- Baldwin E
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- Baman R
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- Bamrungpong P
- Banaeian F
- Banikova A
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- Barcinas R
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- Barnhorst M
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- Barrington P
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- Bart B
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- Bartkowiak A
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- Baszak J
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- Bertolim Precoma D
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- Biniek D
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- Bognar A
- Bojanowska E
- Bokarev I
- Bollova D
- Bolohan F
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- Bonds C
- Bonin K
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- Bosco B
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- Botelho R
- Botero R
- Botha L
- Bouchard A
- Bourlios P
- Boursin P
- Bouzo M
- Bowden W
- Bowen L
- Bowman B
- Boyer M
- Bozek B
- Bradley A
- Braemer U
- Braun D
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- Braunwald E
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- Bridge C
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- Broberg M
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- Bronisz M
- Brown F
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- Browning J
- Brtko M
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- Bruguera Cortada J
- Bruning T
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- Buchholz M
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- Bugueño C
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- Chumakova G
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- Zateyshchikova A
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- Zhao RP
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- Zharinov O
- Zheng X
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- Zhou SX
- Zhukova N
- Zhurba S
- Zidkova E
- Zidkova E
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- Zielinski M
- Zienciuk-Krajka A
- Zimmermann EB
- Zimmermann S
- Zoghi M
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- Zondag M
- Zotova I
- Zubeeva G
- Zyatenkova E
- Ă…kerberg A
- Ă–stberg S
- Ĺśpinar J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
Contains fulltext :
125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)
Ezetimibe added to statin therapy after acute coronary syndromes
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- Ă…ngman K
- Édes I
- Ă–stberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit