A Geometric Approach to Combinatorial Fixed-Point Theorems

We develop a geometric framework that unifies several different combinatorial fixed-point theorems related to Tucker's lemma and Sperner's lemma, showing them to be different geometric manifestations of the same topological phenomena. In doing so, we obtain (1) new Tucker-like and Sperner-like fixed-point theorems involving an exponential-sized label set; (2) a generalization of Fan's parity proof of Tucker's Lemma to a much broader class of label sets; and (3) direct proofs of several Sperner-like lemmas from Tucker's lemma via explicit geometric embeddings, without the need for topological fixed-point theorems. Our work naturally suggests several interesting open questions for future research.Comment: 10 pages; an extended abstract appeared at Eurocomb 201

Towards Large-scale Inconsistency Measurement

We investigate the problem of inconsistency measurement on large knowledge bases by considering stream-based inconsistency measurement, i.e., we investigate inconsistency measures that cannot consider a knowledge base as a whole but process it within a stream. For that, we present, first, a novel inconsistency measure that is apt to be applied to the streaming case and, second, stream-based approximations for the new and some existing inconsistency measures. We conduct an extensive empirical analysis on the behavior of these inconsistency measures on large knowledge bases, in terms of runtime, accuracy, and scalability. We conclude that for two of these measures, the approximation of the new inconsistency measure and an approximation of the contension inconsistency measure, large-scale inconsistency measurement is feasible.Comment: International Workshop on Reactive Concepts in Knowledge Representation (ReactKnow 2014), co-located with the 21st European Conference on Artificial Intelligence (ECAI 2014). Proceedings of the International Workshop on Reactive Concepts in Knowledge Representation (ReactKnow 2014), pages 63-70, technical report, ISSN 1430-3701, Leipzig University, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-15056

A monolithic resonant terahertz sensor element comprising a metamaterial absorber and micro-bolometer

In this article a monolithic resonant terahertz sensor element with a noise equivalent power superior to that of typical commercial room temperature single pixel terahertz detectors and capable of close to real time read-out rates is presented. The detector is constructed via the integration of a metamaterial absorber and a micro-bolometer sensor. An absorption magnitude of 57% at 2.5 THz, a minimum NEP of inline image and a thermal time constant of 68 ms for the sensor are measured. As a demonstration of detector capability, it is employed in a practical Nipkow terahertz imaging system. The monolithic resonant terahertz detector is readily scaled to focal plane array formats by adding standard read-out and addressing circuitry enabling compact, low-cost terahertz imaging

Transposon mutagenesis in a hyper-invasive clinical isolate of Campylobacter jejuni reveals a number of genes with potential roles in invasion

Transposon mutagenesis has been applied to a hyper-invasive clinical isolate of Campylobacter jejuni, 01/51. A random transposon mutant library was screened in an in vitro assay of invasion and 26 mutants with a significant reduction in invasion were identified. Given that the invasion potential of C. jejuni is relatively poor compared to other enteric pathogens, the use of a hyper-invasive strain was advantageous as it greatly facilitated the identification of mutants with reduced invasion. The location of the transposon insertion in 23 of these mutants has been determined; all but three of the insertions are in genes also present in the genome-sequenced strain NCTC 11168. Eight of the mutants contain transposon insertions in one region of the genome (∼14 kb), which when compared with the genome of NCTC 11168 overlaps with one of the previously reported plasticity regions and is likely to be involved in genomic variation between strains. Further characterization of one of the mutants within this region has identified a gene that might be involved in adhesion to host cells

Terahertz single pixel imaging based on a Nipkow disk

We describe a terahertz single pixel imaging system based on a Nipkow disk. Nipkow disks have been used for fast scanning imaging systems since the first experimental television was invented in 1926. In our work, a Nipkow disk with 24 scanning lines was used to provide an axial resolution of 2 mm/pixel. We also show that by implementing a microscanning technique the axial resolution can be further improved to 0.5 mm/pixel. Imaging of several objects was demonstrated to show that this simple scanning system is promising for fast and/or real time terahertz imaging applications

Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders

Biological and mechanistic relevance of intergenic disease-associated genetic loci (IDAGL) containing highly statistically significant disease-linked SNPs remains unknown. Here we present the experimental and clinical evidence revealing important role of IDAGL in human diseases. Targeted RT-PCR screen coupled with sequencing of purified PCR products detects widespread transcription at multiple intergenic disease-associated genomic loci (IDAGL) and identifies 96 small non-coding trans-regulatory RNAs of ~ 100-300 nt in length containing SNPs associated with 21 common human disorders (snpRNAs). Functionality of snpRNAs is supported by multiple independent lines of experimental evidence demonstrating their cell-type-specific expression and evolutionary conservation of sequences, genomic coordinates, and biological effects. Analysis of chromatin state signatures, expression profiling experiments using microarray and Q-PCR technologies, and luciferase reporter assays indicate that many IDAGL are Polycomb-regulated long-range enhancers. Expression of snpRNAs in human and mouse cells markedly affects cellular behavior and induces allele-specific clinically-relevant phenotypic changes: NLRP1-locus snpRNAs exert regulatory effects on monocyte/macrophage trans-differentiation, induce prostate cancer (PC) susceptibility snpRNAs, and transform low-malignancy hormone-dependent human PC cells into highly malignant androgen-independent PC. Q-PCR analysis and luciferase reporter assays demonstrate that snpRNA sequences represent allele-specific “decoy” targets of microRNAs which function as SNP-allele-specific modifiers of microRNA expression and activity. We demonstrate that trans-acting RNA molecules facilitating androgen depletion-independent growth (ADIG) in vitro and castration-resistant (CR) phenotype in vivo of PC contain intergenic 8q24-locus SNP variants which were recently linked with increased risk of developing PC. Expression level of 8q24-locus PC susceptibility snpRNAs is regulated by NLRP1-locus snpRNAs, which are transcribed from the intergenic long-range enhancer sequence located in 17p13 region at ~ 30 kb distance from the NLRP1 gene. Q-PCR analysis of clinical PC samples reveals markedly increased snpRNA expression levels in tumor tissues compared to the adjacent normal prostate [122-fold and 45-fold in Gleason 7 tumors (p = 0.03); 370-fold and 127-fold in Gleason 8 tumors (p = 0.0001); for NLRP1-locus and 8q24-locus SnpRNAs, respectively]. Highly concordant expression profiles of the NLRP1-locus snpRNAs and 8q24 CR-locus snpRNAs (r = 0.896; p < 0.0001) in clinical PC samples and experimental evidence of trans-regulatory effects of NLRP1-locus snpRNAs on expression of 8q24-locus SnpRNAs indicate that ADIG and CR phenotype of human PC cells can be triggered by RNA molecules transcribed from the NLRP1-locus intergenic enhancer and down-stream activation of the 8q24-locus snpRNAs. Our results define the intergenic NLRP1 and 8q24 regions as regulatory loci of ADIG and CR phenotype of human PC, reveal previously unknown molecular links between the innate immunity/inflammasome system and development of hormone-independent PC, and identify novel diagnostic and therapeutic targets exploration of which should be highly beneficial for clinical management of PC

Is There a Case for Mandating Directly Elected Mayors in Australian Local Government? Lessons from the 2012 Queensland Local Government Elections

© 2015 Institute of Public Administration Australia. A 'semi-executive' model for Australian mayors, inclusive of direct election, is presently being explored in the Australian local sector (see, in particular, Sansom, 2012). This paper takes advantage of the differences across Australia's federation to examine the recent experience of directly elected mayors in Queensland, especially the results of local government elections held in 2012. It is argued that several factors contributed to the high turnover rates of both mayors and councillors, including the 2012 Queensland state election and the 2008 amalgamation process. However, the requirement for directly elected mayors was an important factor contributing to what the Local Government Association of Queensland (LGAQ, 2012, 12) described as a 'significantly high' proportion of 'corporate knowledge' being lost. Moreover, the direct election of mayors, in particular those charged with 'semi-executive' authority, is fraught with problems and thus should not to be implemented in all Australian local government systems

Religion and Life Satisfaction Down Under

© 2014, Springer Science+Business Media Dordrecht. We investigated the association between religious involvement and life satisfaction using panel data from the 2004, 2007, and 2010 waves of the Household, Income and Labour Dynamics in Australia (HILDA) survey. Our study provides strong evidence of an association between attendance at religious services and life satisfaction in the Australian social context. While social resources mediate this association, there appears to be a remaining direct influence of attendance at religious services on life satisfaction. To unravel this association, there is a need to disentangle and separately assess the influence that ‘religious social resources’ and ‘secular social resources’ may have on life satisfaction

Person centred discharge education following coronary artery bypass graft : a critical review

Aims and objectives: This critical review examines the extent that individualised education helps reduce depression, anxiety and improves self-care for people who have undergone Coronary Artery Bypass Graft surgery (CABG). Background: Individualised discharge planning is increasingly important following cardiac surgery due to recurrent admissions as well as the issue of anxiety and depression, often due to lack of preparation. The hospital to home transition is fundamental in the recovery process. Individualised education and person centred care ensures that patients’ educational needs are met. This empowers patients, increasing self-efficacy or confidence, resulting in autonomy, a smoother discharge process and avoiding post discharge problems and rehospitalisation. Design: A critical review of published peer-reviewed literature was conducted. Methods: Electronic databases searched included MEDLINE, CINAHL, the Cochrane Library and PsychInfo 2009-2015.Data was selected and extracted by three reviewers based on PRISMA guidelines (Moher et al 2009). Results: Eight articles were identified for review, and a CASP framework was used to determine the quality of the papers, all of the papers focussed on CABG. The designs were typically experimental or quasi-experimental with two reviews. Conclusion: A greater understanding of the patients’ needs allows tailored education to be provided which promotes self-care management. This level of patient empowerment increases confidence and ultimately minimise anxiety and depression. Despite the varying teaching and learning methods associated with individualised education, patient centred education has the potential to assist cardiac nurses in adequately preparing patients for discharge following their CABG. Relevance to clinical practice: Development of individualised education programmes is crucial in preparing patients for discharge. The reduction in readmission to hospital has a significant effect on already stretched resources, and the reduction in post-operative complications during the recovery period linked with depression and anxiety will have a positive effect on the individuals’ ability to self-care, health and wellbeing

A terahertz polarization insensitive dual band metamaterial absorber

Metamaterial absorbers have attracted considerable attention for applications in the terahertz range. In this Letter, we report the design, fabrication, and characterization of a terahertz dual band metamaterial absorber that shows two distinct absorption peaks with high absorption. By manipulating the periodic patterned structures as well as the dielectric layer thickness of the metal–dielectric–metal structure, significantly high absorption can be obtained at specific resonance frequencies. Finite-difference time-domain modeling is used to design the structure of the absorber. The fabricated devices have been characterized using a Fourier transform IR spectrometer. The experimental results show two distinct absorption peaks at 2.7 and 5.2 THz, which are in good agreement with the simulation. The absorption magnitudes at 2.7 and 5.2 THz are 0.68 and 0.74, respectively