Disruption and rescue of interareal theta phase coupling and adaptive behavior

Rescuing executive functions in people with neurological and neuropsychiatric disorders has been a major goal of psychology and neuroscience for decades. Innovative computer-training regimes for executive functions have made tremendous inroads, yet the positive effects of training have not always translated into improved cognitive functioning and often take many days to emerge. In the present study, we asked whether it was possible to immediately change components of executive function by directly manipulating neural activity using a stimulation technology called high-definition transcranial alternating current stimulation (HD-tACS). Twenty minutes of inphase stimulation over medial frontal cortex (MFC) and right lateral prefrontal cortex (lPFC) synchronized theta (∼6 Hz) rhythms between these regions in a frequency and spatially specific manner and rapidly improved adaptive behavior with effects lasting longer than 40 min. In contrast, antiphase stimulation in the same individuals desynchronized MFC-lPFC theta phase coupling and impaired adaptive behavior. Surprisingly, the exogenously driven impairments in performance could be instantly rescued by reversing the phase angle of alternating current. The results suggest executive functions can be rapidly up- or down-regulated by modulating theta phase coupling of distant frontal cortical areas and can contribute to the development of tools for potentially normalizing executive dysfunction in patient populations.Published versio

Spanish Entomology: Past and Present

Excerpt: The history of pure entomology in Spain begins during the Eighteenth Century and continues until today with emphasis upon systematics. The reasons for this are several, but chief among them must be mentioned the extraordinary richness and diversity of the Iberian entomological fauna. This peninsula was a landbridge that in earlier geological times linked Europe and Africa. It is highly zoned and stratified, and supports a variety of faunal elements including European, Mediterranean, African, Atlantic and indigenous. This rich fauna, together with a paucity of skilled entomologists, has resulted in insufficient study of Iberian insects. Except for the Orthoptera, and possibly one or two other groups, our insect fauna is still in the alpha taxonomic status, with the consequence that it is generally not feasible to carry out the comparative anatomical, ecological, physiological, or behavioral studies that can be accomplished in countries with either a better-known fauna or with a poorer one

Shade increases cereal production in mediterranean conditions facing the climate change

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Preliminary analysis of the dermersal fish assemblages in the Bangladesh waters of the Bay of Bengal

This paper presents the results of analyses of the demersal fish assemblages in Bangladesh waters of the Bay of Bengal. Catch data from three trawl survey cruises from January to February 1985 covering 135 stations were utilized for community structure analysis using TWINSPAN and DCA techniques. Both techniques separated the deepwater stations (> 90 m) from the shallow areas (Fishery resources, Demersal fisheries, Fishery surveys, Biomass, Population density, Shrimp fisheries, Catch/effort, Trawling, Population characteristics, ISW, India, Bengal Bay,

Tastes and odours in potable water:perception versus reality

Tastes and odours are amongst the few water quality standards immediately apparent to a consumer and, as a result, account for most consumer complaints about water quality. Although taste and odour problems can arise from a great many sources, from an operational point of view they are either ”predictable” or ”unpredictable”. The former - which include problems related to actinomycete and algal growth - have a tendency to occur in certain types of water under certain combinations of conditions, whereas the latter - typically chemical spills - can occur anywhere. Long-term control is one option for predictable problems, although biomanipulation on a large scale has had utile success. Detection and avoidance is a more practicable option for both predictable and unpredictable problems, particularly if the distribution network can be serviced from other sources. Where these are not feasible, then water treatment, typically using activated carbon, is possible. In general there is a reasonable understanding of what compounds cause taste and odour problems, and how to treat these. An efficient taste and odour control programme therefore relies ultimately on good management of existing resources. However, a number of problems lie outside the remit of water supply companies and will require more fundamental regulation of activities in the catchment

Correcting menu usability problems with sound

Future human-computer interfaces will use more than just graphical output to display information. In this paper we suggest that sound and graphics together can be used to improve interaction. We describe an experiment to improve the usability of standard graphical menus by the addition of sound. One common difficulty is slipping off a menu item by mistake when trying to select it. One of the causes of this is insufficient feedback. We designed and experimentally evaluated a new set of menus with much more salient audio feedback to solve this problem. The results from the experiment showed a significant reduction in the subjective effort required to use the new sonically-enhanced menus along with significantly reduced error recovery times. A significantly larger number of errors were also corrected with sound

Heat conduction from irregular surfaces

The effect of irregularities on the rate of heat conduction from a two-dimensional isothermal surface into a semi infinite medium is considered. The effect of protrusions, depressions, and surface roughness is quantified in terms of the displacement of the linear temperature profile prevailing far from the surface. This shift, coined the displacement length, is designated as an appropriate global measure of the effect of the surface indentations incorporating the particular details of the possibly intricate geometry. To compute the displacement length, Laplace's equation describing the temperature distribution in the semi-infinite space above the surface is solved numerically by a modified Schwarz-Christoffel transformation whose computation requires solving a system of highly non-linear algebraic equations by iterative methods, and an integral equation method originating from the single-layer integral representation of a harmonic function involving the periodic Green's function. The conformal mapping method is superior in that it is capable of handling with high accuracy a large number of vertices and intricate wall geometries. On the other hand, the boundary integral method yields the displacement length as part of the solution. Families of polygonal wall shapes composed of segments in regular, irregular, and random arrangement are considered, and pre-fractal geometries consisting of large numbers of vertices are analyzed. The results illustrate the effect of wall geometry on the flux distribution and on the overall enhancement in the rate of transport for regular and complex wall shapes

Downsizing of acute inpatient beds associated with private finance initiative: Scotland's case study

OBJECTIVES: To evaluate whether the projected 24% reduction in acute bed numbers in Lothian hospitals, which formed part of the private finance initiative (PFI) plans for the replacement Royal Infirmary of Edinburgh, is being compensated for by improvements in efficiency and greater use of community facilities, and to ascertain whether there is an independent PFI effect by comparing clinical activity and performance in acute specialties in Lothian hospitals with other NHS hospitals in Scotland. DESIGN: Comparison of projected and actual trends in acute bed capacity and inpatient and day case admissions in the first five years (1995-6 to 2000-1) of Lothian Health Board's integrated healthcare plan. Population study of trends in bed rate, hospital activity, length of stay, and throughput in Lothian hospitals compared with the rest of Scotland from 1990-1 to 2000-1. MAIN OUTCOME MEASURES: Staffed bed rates, admission rates, mean lengths of stay, occupancy, and throughput in four adult acute specialty groups in 1990-1, 1995-6, and 2000-1. RESULTS: By 2000-1, rates for inpatient admission in all acute, medical, surgical, and intensive therapy specialties in Lothian hospitals were respectively 20%, 6%, 28%, and 38% below those in the rest of Scotland. Day case rates in all acute and acute surgical specialties were 13% and 33% lower. The proportion of delayed discharges in staffed acute and post-acute NHS beds in Lothian hospitals exceeded the Scottish average (15% and 12% respectively; P<0.001). CONCLUSION: The planning targets and increase in clinical activity in acute specialties in Lothian hospitals associated with PFI had not been achieved by 2000-1. The effect on clinical activity has been a steeper decline in the number of acute beds and rates of admission in Lothian hospitals compared with the rest of Scotland between 1995-6 and 2000-1

EEG-informed fMRI reveals spatiotemporal characteristics of perceptual decision making

Single-unit and multiunit recordings in primates have already established that decision making involves at least two general stages of neural processing: representation of evidence from early sensory areas and accumulation of evidence to a decision threshold from decision-related regions. However, the relay of information from early sensory to decision areas, such that the accumulation process is instigated, is not well understood. Using a cued paradigm and single-trial analysis of electroencephalography (EEG), we previously reported on temporally specific components related to perceptual decision making. Here, we use information derived from our previous EEG recordings to inform the analysis of fMRI data collected for the same behavioral task to ascertain the cortical origins of each of these EEG components. We demonstrate that a cascade of events associated with perceptual decision making takes place in a highly distributed neural network. Of particular importance is an activation in the lateral occipital complex implicating perceptual persistence as a mechanism by which object decision making in the human brain is instigated