45 research outputs found
Shell model in the complex energy plane and two-particle resonances
An implementation of the shell-model to the complex energy plane is
presented. The representation used in the method consists of bound
single-particle states, Gamow resonances and scattering waves on the complex
energy plane. Two-particle resonances are evaluated and their structure in
terms of the single-particle degreees of freedom are analysed. It is found that
two-particle resonances are mainly built upon bound states and Gamow
resonances, but the contribution of the scattering states is also important.Comment: 20 pages, 9 figures, submitted to Phys.Rev.
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk
Regular rates of popular culture change reflect random copying
Almost by definition, “popular culture” reflects the effects of most people imitating those around them. At the same time, trends and fashions are constantly changing, with future outcomes potentially irrational and nearly impossible to predict. A simple null model, which captures these seemingly conflicting tendencies of conformity and change, involves the random copying of cultural variants between individuals, with occasional innovation. Here, we show that the random-copying model predicts a continual flux of initially obscure new ideas (analogous to mutations) becoming highly popular by chance alone, such that the turnover rate on a list of most popular variants depends on the list size and the amount of innovation but not on population size. We also present evidence for remarkably regular turnover on “pop charts”—including the most popular music, first names, and dog breeds in 20th-century United States—which fits this expectation. By predicting parametric effects on the turnover of popular fashion, the random-copying model provides an additional means of characterizing collective copying behavior in culture evolution
Bioengineering in the Repair of Irradiated Normal Tissue by Bone Marrow Derived Stem Cell Populations
Consultation-liaison psychiatry: Does it help to get organized?
info:eu-repo/semantics/publishe
The ECLW collaborative study. 2: Patient registration form (PRF) instrument, training and reliability
info:eu-repo/semantics/publishe
The European Consultation-Liaison Workgroup (ECLW) collaborative study.1: General outline
info:eu-repo/semantics/publishe