Asymmetric vortex merger: mechanism and criterion

The merging of two unequal co-rotating vortices in a viscous fluid is investigated. Two-dimensional numerical simulations of initially equal sized Lamb-Oseen vortices with differing relative strengths are performed. Results show how the disparity in deformation rates between the vortices alters the interaction. Key physical mechanisms associated with vortex merging are identified. A merging criterion is formulated in terms of the relative timing of core detrainment and destruction. A critical strain parameter is defined to characterize the establishment of core detrainment. This parameter is shown to be directly related to the critical aspect ratio in the case of symmetric merger

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies

Homostrophic Vortex Interaction under External Strain in a Coupled QG-SQG Model

International audienceThe interaction between two co-rotating vortices, embedded in a steady external strain field, is studied in a coupled Quasi-Geostrophic — Surface Quasi-Geostrophic (hereafter referred to as QG-SQG) model. One vortex is an anomaly of surface density, and the other is an anomaly of internal potential vorticity. The equilibria of singular point vortices and their stability are presented first. The number and form of the equilibria are determined as a function of two parameters: the external strain rate and the vertical separation between the vortices. A curve is determined analytically which separates the domain of existence of one saddle-point, and that of one neutral point and two saddle-points. Then, a Contour-Advective Semi-Lagrangian (hereafter referred to as CASL) numerical model of the coupled QG-SQG equations is used to simulate the time-evolution of a sphere of uniform potential vorticity, with radius R at depth −2H interacting with a disk of uniform density anomaly, with radius R, at the surface. In the absence of external strain, distant vortices co-rotate, while closer vortices align vertically, either completely or partially (depending on their initial distance). With strain, a fourth regime appears in which vortices are strongly elongated and drift away from their common center, irreversibly. An analysis of the vertical tilt and of the horizontal deformation of the internal vortex in the regimes of partial or complete alignment is used to quantify the three-dimensional deformation of the internal vortex in time. A similar analysis is performed to understand the deformation of the surface vortex