269 research outputs found
Self Consistent Molecular Field Theory for Packing in Classical Liquids
Building on a quasi-chemical formulation of solution theory, this paper
proposes a self consistent molecular field theory for packing problems in
classical liquids, and tests the theoretical predictions for the excess
chemical potential of the hard sphere fluid. Results are given for the self
consistent molecular fields obtained, and for the probabilities of occupancy of
a molecular observation volume. For this system, the excess chemical potential
predicted is as accurate as the most accurate prior theories, particularly the
scaled particle (Percus-Yevick compressibility) theory. It is argued that the
present approach is particularly simple, and should provide a basis for a
molecular-scale description of more complex solutions.Comment: 6 pages and 5 figure
A critique of non-extensive q-entropy for thermal statistics
During the past dozen years there have been numerous articles on a relation
between entropy and probability which is non-additive and has a parameter
that depends on the nature of the thermodynamic system under consideration. For
this relation corresponds to the Boltzmann-Gibbs entropy, but for other
values of it is claimed that it leads to a formalism which is consistent
with the laws of thermodynamics. However, it is shown here that the joint
entropy for systems having {\it different} values of is not defined in this
formalism, and consequently fundamental thermodynamic concepts such as
temperature and heat exchange cannot be considered for such systems. Moreover,
for the probability distribution for weakly interacting systems does
not factor into the product of the probability distribution for the separate
systems, leading to spurious correlations and other unphysical consequences,
e.g. non-extensive energy, that have been ignored in various applications given
in the literature
Interacting New Agegraphic Dark Energy in a Cyclic Universe
The main goal of this work is investigation of NADE in the cyclic universe
scenario. Since, cyclic universe is explained by a phantom phase (),
it is shown when there is no interaction between matter and dark energy, ADE
and NADE do not produce a phantom phase, then can not describe cyclic universe.
Therefore, we study interacting models of ADE and NADE in the modified
Friedmann equation. We find out that, in the high energy regime, which it is a
necessary part of cyclic universe evolution, only NADE can describe this
phantom phase era for cyclic universe. Considering deceleration parameter tells
us that the universe has a deceleration phase after an acceleration phase, and
NADE is able to produce a cyclic universe. Also it is found valuable to study
generalized second law of thermodynamics. Since the loop quantum correction is
taken account in high energy regime, it may not be suitable to use standard
treatment of thermodynamics, so we turn our attention to the result of
\citep{29}, which the authors have studied thermodynamics in loop quantum
gravity, and we show that which condition can satisfy generalized second law of
thermodynamics.Comment: 8 pages, 3 figure
Effect of Divalproex on Brain Morphometry, Chemistry, and Function in Youth at High-Risk for Bipolar Disorder: A Pilot Study
Abstract Objective: Divalproex has been found efficacious in treating adolescents with and at high risk for bipolar disorder (BD), but little is known about the effects of mood stabilizers on the brain itself. We sought to examine the effects of divalproex on the structure, chemistry, and function of specific brain regions in children at high-risk for BD. Methods: A total of 24 children with mood dysregulation but not full BD, all offspring of a parent with BD, were treated with divalproex monotherapy for 12 weeks. A subset of 11 subjects and 6 healthy controls were scanned with magnetic resonance imaging (MRI, magnetic resonance spectroscopy [MRS], and functional MRI [fMRI]) at baseline and after 12 weeks. Results: There were no significant changes in amygdalar or cortical volume found over 12 weeks. Furthermore, no changes in neurometabolite ratios were found. However, we found the degree of decrease in prefrontal brain activation to correlate with degree of decrease in depressive symptom severity. Conclusions: Bipolar offspring at high risk for BD did not show gross morphometric, neurometabolite, or functional changes after 12 weeks of treatment with divalproex. Potential reasons include small sample size, short exposure to medications, or lack of significant neurobiological impact of divalproex in this particular population
Field Measurements of Terrestrial and Martian Dust Devils
Surface-based measurements of terrestrial and martian dust devils/convective vortices provided from mobile and stationary platforms are discussed. Imaging of terrestrial dust devils has quantified their rotational and vertical wind speeds, translation speeds, dimensions, dust load, and frequency of occurrence. Imaging of martian dust devils has provided translation speeds and constraints on dimensions, but only limited constraints on vertical motion within a vortex. The longer mission durations on Mars afforded by long operating robotic landers and rovers have provided statistical quantification of vortex occurrence (time-of-sol, and recently seasonal) that has until recently not been a primary outcome of more temporally limited terrestrial dust devil measurement campaigns. Terrestrial measurement campaigns have included a more extensive range of measured vortex parameters (pressure, wind, morphology, etc.) than have martian opportunities, with electric field and direct measure of dust abundance not yet obtained on Mars. No martian robotic mission has yet provided contemporaneous high frequency wind and pressure measurements. Comparison of measured terrestrial and martian dust devil characteristics suggests that martian dust devils are larger and possess faster maximum rotational wind speeds, that the absolute magnitude of the pressure deficit within a terrestrial dust devil is an order of magnitude greater than a martian dust devil, and that the time-of-day variation in vortex frequency is similar. Recent terrestrial investigations have demonstrated the presence of diagnostic dust devil signals within seismic and infrasound measurements; an upcoming Mars robotic mission will obtain similar measurement types
Factors associated with adherence to immunomodulator treatment in people with multiple sclerosis
Identification of Resource Use and Associated Costs for Viral Meningitis
ABSTRACT Purpose: This study involved identifying resource use and assigning monetary value to the diagnostic work-up and management of viral meningitis. Methodology: Using a previously established decision analytic framework, various resources were identified as part of routine management of viral meningitis. Secondary database analyses were used to quantify resources and assign a monetary value as a part of routine management of viral meningitis requiring use of the resource units identified in the decision analytic framework. Discharge data sources from the states of California, Florida, and Illinois, and Medicaid data sources from the state of Pennsylvania, were used for the purpose of analysis. Principal Findings: Physician visits, emergency room visits, hospital admissions, procedures, and medications were identified as the major resources used. Lumbar punctures, CT scans, and antibiotics were identified as the major procedures and medications utilized. No significant difference was found in the major resources used between the states' discharge data and the Medicaid data sources. The mean total charges for patient admissions with CT scans were significantly higher than for patient admissions without CT scans (7,841.30, P<0.05). The mean lengths of stay for patients with CT scan were significantly higher than for patient admissions without CT scans (4.71 days vs. 3.88 days, P<0.05). The patient readmission rate was 10.7 percent, while the readmission rate for episodes with more than one hospitalization was 11.1 percent. The mean charge associated with readmission was $12,200
Inverse Power Law Quintessence with Non-Tracking Initial Conditions
A common property of popular models of quintessence dark energy is the
convergence to a common solution from a large range of the initial conditions.
We re-examine the popular inverse power-law model of quintessence (where the
common solution is dubbed as the 'tracker') with particular attention to the
initial conditions for the field and their influence on the evolution. We find
that previously derived limits on the parameters of the potential in this model
are valid only in a range of initial conditions. A reasonably sharp boundary
lies where the initial energy density of the scalar field is equal to that of
the background radiation component. An initial quintessence energy density
above this equipartition value lead to a solution that will not have joined the
tracker solution by the present epoch. These non-tracker solutions possess the
property that their present equation of state is very compatible with the
observed bounds and independent of the exponent of the potential.Comment: RevTEX4, 9 figure
Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk Meta-Analysis of 119 Clinical Trials Involving 100 667 Patients
Background:
To quantify the association between effects of interventions on carotid intima-media thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk.
Methods:
We systematically collated data from randomized, controlled trials. cIMT was assessed as the mean value at the common-carotid-artery; if unavailable, the maximum value at the common-carotid-artery or other cIMT measures were used. The primary outcome was a combined CVD end point defined as myocardial infarction, stroke, revascularization procedures, or fatal CVD. We estimated intervention effects on cIMT progression and incident CVD for each trial, before relating the 2 using a Bayesian meta-regression approach.
Results:
We analyzed data of 119 randomized, controlled trials involving 100 667 patients (mean age 62 years, 42% female). Over an average follow-up of 3.7 years, 12 038 patients developed the combined CVD end point. Across all interventions, each 10 μm/y reduction of cIMT progression resulted in a relative risk for CVD of 0.91 (95% Credible Interval, 0.87–0.94), with an additional relative risk for CVD of 0.92 (0.87–0.97) being achieved independent of cIMT progression. Taken together, we estimated that interventions reducing cIMT progression by 10, 20, 30, or 40 μm/y would yield relative risks of 0.84 (0.75–0.93), 0.76 (0.67–0.85), 0.69 (0.59–0.79), or 0.63 (0.52–0.74), respectively. Results were similar when grouping trials by type of intervention, time of conduct, time to ultrasound follow-up, availability of individual-participant data, primary versus secondary prevention trials, type of cIMT measurement, and proportion of female patients.
Conclusions:
The extent of intervention effects on cIMT progression predicted the degree of CVD risk reduction. This provides a missing link supporting the usefulness of cIMT progression as a surrogate marker for CVD risk in clinical trials
Cold Plus Hot Dark Matter Cosmology in the Light of Solar and Atmospheric Neutrino Oscillations
We explore the implications of possible neutrino oscillations, as indicated
by the solar and atmospheric neutrino experiments, for the cold plus hot dark
matter scenario of large scale structure formation. We find that there are
essentially three distinct schemes that can accommodate the oscillation data
and which also allow for dark matter neutrinos. These include (i) three nearly
degenerate (in mass) neutrinos, (ii) non-degenerate masses with in
the eV range, and (iii) nearly degenerate pair (in the eV
range), with the additional possibility that the electron neutrino is
cosmologically significant. The last two schemes invoke a `sterile' neutrino
which is light (< or ~ eV). We discuss the implications of these schemes for
and oscillation, and find
that scheme (ii) in particular, predicts them to be in the observable range. As
far as structure formation is concerned, we compare the one neutrino flavor
case with a variety of other possibilities, including two and three degenerate
neutrino flavors. We show, both analytically and numerically, the effects of
these neutrino mass scenarios on the amplitude of cosmological density
fluctuations. With a Hubble constant of 50 km s Mpc, a spectral
index of unity, and , the two and three flavor
scenarios fit the observational data marginally better than the single flavor
scheme. However, taking account of the uncertainties in these parameters, we
show that it is premature to pick a clear winner.Comment: 1 LaTEX file plus 1 uuencoded Z-compressed tar file with 3 postscript
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