Group explicit methods for hyperbolic equations

AbstractHere the strategy of the group explicit (GE) methods is applied to the numerical solution of hyperbolic partial differential equations. Theoretical aspects of the stability, consistency, convergence and truncation errors of this new class of methods are presented with supporting numerical evidence

Group explicit methods for the numerical solution of the wave equation

AbstractThe applicability of the group explicit (GE) methods to the numerical solution of hyperbolic partial differential equations of second-order is discussed in this paper following closely many of the ideas presented in an earlier related paper

Thermal modeling of terahertz quantum-cascade lasers: comparison of optical waveguides

We compare a set of experimental lattice temperature profiles measured in a surface-emitting terahertz (THz) quantum-cascade laser (QCL) with the results of a 2-D anisotropic heat diffusion model. We evaluate the temperature dependence of the cross-plane thermal conductivity (kappaperp) of the active region which is known to be strongly anisotropic due to its superlattice-like nature. Knowledge of kappaperp and its temperature dependence is crucial in order to improve the temperature performance of THz QCLs and this has been used to investigate the longitudinal lattice temperature distribution of the active region and to compare the thermal properties of metal-metal and semi-insulating surface-plasmon THz optical waveguides using a 3-D anisotropic heat diffusion model

What Would Vincent Study Abroad? Option for the Poor and Systemic Change for the Development of Socially Responsible Leaders

The effectiveness of the DePaul University School of Public Service Chiapas Program is evaluated according to “Vincentian values of experiential learning, systemic change, and the option for the poor.” Including students’ own words, the article summarizes what participants learn as they work directly with poor persons, their leaders, indigenous organizations, local NGOs, and Mexican academic institutions in Chiapas. As Marco Tavanti and Heather Evans write, the program’s goal “is not only to increase knowledge and skills but to challenge and transform cultural attitudes, learn from context, and engage in professional collaboration and dialogues for social change.” The value of system thinking is explained. The program puts the Vincentian approach to systemic change into practice. The connections that students make between conditions in Chiapas and those in Chicago are described, as are projects students have initiated on their return. Tavanti and Evans argue that all study abroad programs should transform participants into global citizens who have a profound awareness of poverty and a commitment to social justice

New Critical Behavior in Einstein-Yang-Mills Collapse

We extend the investigation of the gravitational collapse of a spherically symmetric Yang-Mills field in Einstein gravity and show that, within the black hole regime, a new kind of critical behavior arises which separates black holes formed via Type I collapse from black holes formed through Type II collapse. Further, we provide evidence that these new attracting critical solutions are in fact the previously discovered colored black holes with a single unstable mode.Comment: 13 pages, 4 figure

Water wave propagation and scattering over topographical bottoms

Here I present a general formulation of water wave propagation and scattering over topographical bottoms. A simple equation is found and is compared with existing theories. As an application, the theory is extended to the case of water waves in a column with many cylindrical steps

Clinical investigation of an outbreak of alveolitis and asthma in a car engine manufacturing plant

Background Exposure to metal working fluid (MWF) has been associated with outbreaks of EAA in the US, with bacterial contamination of MWF being a possible cause, but was uncommon in the UK. Twelve workers developed extrinsic allergic alveolitis (EAA) in a car engine manufacturing plant in the UK, presenting clinically between December 2003 and May 2004. This paper reports the subsequent epidemiological investigation of the whole workforce. This had three aims:- • To measure the extent of the outbreak by identifying other workers who may have developed EAA or other work-related respiratory diseases. • To provide case-detection so that those affected can be treated. • To provide epidemiological data to identify the cause of the outbreak. Methods The outbreak was investigated in a three-phase cross-sectional survey of the workforce. Phase I A respiratory screening questionnaire was completed by 808/836 workers (96.7%) in May 2004. Phase II 481 employees with at least one respiratory symptom on screening and 50 asymptomatic controls were invited for investigation at the factory in June 2004. This included a questionnaire, spirometry and clinical opinion. 454/481(94.4%) responded along with 48/50(96%) controls. Workers were identified who needed further investigation and serial measurements of peak expiratory flow (PEF). Phase III 162 employees were seen at the Birmingham Occupational Lung Disease clinic. 198 employees returned PEF records, including 141 of the 162 who attended for clinical investigation. Case definitions for diagnoses were agreed. Results 87 workers (10.4% of workforce) met case definitions for occupational lung disease, comprising EAA(19), occupational asthma(74) and humidifier fever(7). 12 workers had more than one diagnosis. The peak onset of work-related breathlessness was Spring 2003. The proportion of workers affected was higher for those using metal working fluid (MWF) from a large sump(27.3%) compared with working all over the manufacturing area (7.9%) (OR=4.39,p<0.001). Two workers had positive specific provocation tests to the used but not the unused MWF solution. Conclusions Extensive investigation of the outbreak of EAA detected a large number of affected workers, not only with EAA but also occupational asthma. This is the largest reported outbreak in Europe. Mist from used MWF is the likely cause. In workplaces using MWF, there is a need to carry out risk assessments, to monitor and maintain fluid quality, to control mist and to carry out respiratory health surveillance

Nerve growth factor improves the muscle regeneration capacity of muscle stem cells in dystrophic muscle.

Researchers have attempted to use gene- and cell-based therapies to restore dystrophin and alleviate the muscle weakness that results from Duchenne muscular dystrophy (DMD). Our research group has isolated populations of muscle-derived stem cells (MDSCs) from the postnatal skeletal muscle of mice. In comparison with satellite cells, MDSCs display an improved transplantation capacity in dystrophic mdx muscle that we attribute to their ability to undergo long-term proliferation, self-renewal, and multipotent differentiation, including differentiation toward endothelial and neuronal lineages. Here we tested whether the use of nerve growth factor (NGF) improves the transplantation efficiency of MDSCs. We used two methods of in vitro NGF stimulation: retroviral transduction of MDSCs with a CL-NGF vector and direct stimulation of MDSCs with NGF protein. Neither method of NGF treatment changed the marker profile or proliferation behavior of the MDSCs, but direct stimulation with NGF protein significantly reduced the in vitro differentiation ability of the cells. NGF stimulation also significantly enhanced the engraftment efficiency of MDSCs transplanted within the dystrophic muscle of mdx mice, resulting in the regeneration of numerous dystrophin-positive muscle fibers. These findings highlight the importance of NGF as a modulatory molecule, the study of which will broaden our understanding of its biologic role in the regeneration and repair of skeletal muscle by musclederived cells