Towards the deconstruction of M-theory

We argue that there is an equivalence of M-theory on T^3 \times A_{N-1} with a four-dimensional non-supersymmetric quiver gauge theory on the Higgs branch. The quiver theory in question has gauge group SU(N)^{N_4N_6N_8} and is considered in a strong coupling and large N_{4,6,8} limit. We provide field- and string-theoretical evidence for the equivalence making use of the deconstruction technique. In particular, we find wrapped M2-branes in the mass spectrum of the quiver theory at low energies.Comment: LaTeX, 15 pages, 4 figures, added reference

Alfv\'en Reflection and Reverberation in the Solar Atmosphere

Magneto-atmospheres with Alfv\'en speed [a] that increases monotonically with height are often used to model the solar atmosphere, at least out to several solar radii. A common example involves uniform vertical or inclined magnetic field in an isothermal atmosphere, for which the Alfv\'en speed is exponential. We address the issue of internal reflection in such atmospheres, both for time-harmonic and for transient waves. It is found that a mathematical boundary condition may be devised that corresponds to perfect absorption at infinity, and, using this, that many atmospheres where a(x) is analytic and unbounded present no internal reflection of harmonic Alfv\'en waves. However, except for certain special cases, such solutions are accompanied by a wake, which may be thought of as a kind of reflection. For the initial-value problem where a harmonic source is suddenly switched on (and optionally off), there is also an associated transient that normally decays with time as O(t-1) or O(t-1 ln t), depending on the phase of the driver. Unlike the steady-state harmonic solutions, the transient does reflect weakly. Alfv\'en waves in the solar corona driven by a finite-duration train of p-modes are expected to leave such transients.Comment: Accepted by Solar Physic

Bounds on Four-Fermion Contact Interactions Induced by String Resonances

Based on tree-level open-string scattering amplitudes in the low string-scale scenario, we derive the massless fermion scattering amplitudes. The amplitudes are required to reproduce those of the Standard Model at tree level in the low energy limit. We then obtain four-fermion contact interactions by expanding in inverse powers of the string scale and explore the constraints on the string scale from low energy data. The Chan-Paton factors and the string scale are treated as free parameters. We find that data from the neutral and charged current processes at HERA, Drell-Yan process at the Tevatron, and from LEP-II put lower bounds on the string scale M_S >= 0.9-1.3 TeV for typical values of the Chan-Paton factors, which are comparable to Tevatron bounds on Z' and W' masses.Comment: 13 pages, 1 ps figure, version to appear in PR

Composite grading algorithm for the National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)

Background: The Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events is an item library designed for eliciting patient-reported adverse events in oncology. For each adverse event, up to three individual items are scored for frequency, severity, and interference with daily activities. To align the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events with other standardized tools for adverse event assessment including the Common Terminology Criteria for Adverse Events, an algorithm for mapping individual items for any given adverse event to a single composite numerical grade was developed and tested. Methods: A five-step process was used: (1) All 179 possible Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events score combinations were presented to 20 clinical investigators to subjectively map combinations to single numerical grades ranging from 0 to 3. (2) Combinations with <75% agreement were presented to investigator committees at a National Clinical Trials Network cooperative group meeting to gain majority consensus via anonymous voting. (3) The resulting algorithm was refined via graphical and tabular approaches to assure directional consistency. (4) Validity, reliability, and sensitivity were assessed in a national study dataset. (5) Accuracy for delineating adverse events between study arms was measured in two Phase III clinical trials (NCT02066181 and NCT01522443). Results: In Step 1, 12/179 score combinations had <75% initial agreement. In Step 2, majority consensus was reached for all combinations. In Step 3, five grades were adjusted to assure directional consistency. In Steps 4 and 5, composite grades performed well and comparably to individual item scores on validity, reliability, sensitivity, and between-arm delineation. Conclusion: A composite grading algorithm has been developed and yields single numerical grades for adverse events assessed via the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events, and can be useful in analyses and reporting

Salinity tolerance of diapausing eggs of freshwater zooplankton

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73091/1/j.1365-2427.2004.01185.x.pd

The three-dimensional random field Ising magnet: interfaces, scaling, and the nature of states

The nature of the zero temperature ordering transition in the 3D Gaussian random field Ising magnet is studied numerically, aided by scaling analyses. In the ferromagnetic phase the scaling of the roughness of the domain walls, $w\sim L^\zeta$, is consistent with the theoretical prediction $\zeta = 2/3$. As the randomness is increased through the transition, the probability distribution of the interfacial tension of domain walls scales as for a single second order transition. At the critical point, the fractal dimensions of domain walls and the fractal dimension of the outer surface of spin clusters are investigated: there are at least two distinct physically important fractal dimensions. These dimensions are argued to be related to combinations of the energy scaling exponent, $\theta$, which determines the violation of hyperscaling, the correlation length exponent $\nu$, and the magnetization exponent $\beta$. The value $\beta = 0.017\pm 0.005$ is derived from the magnetization: this estimate is supported by the study of the spin cluster size distribution at criticality. The variation of configurations in the interior of a sample with boundary conditions is consistent with the hypothesis that there is a single transition separating the disordered phase with one ground state from the ordered phase with two ground states. The array of results are shown to be consistent with a scaling picture and a geometric description of the influence of boundary conditions on the spins. The details of the algorithm used and its implementation are also described.Comment: 32 pp., 2 columns, 32 figure

Dragon-kings: mechanisms, statistical methods and empirical evidence

This introductory article presents the special Discussion and Debate volume "From black swans to dragon-kings, is there life beyond power laws?" published in Eur. Phys. J. Special Topics in May 2012. We summarize and put in perspective the contributions into three main themes: (i) mechanisms for dragon-kings, (ii) detection of dragon-kings and statistical tests and (iii) empirical evidence in a large variety of natural and social systems. Overall, we are pleased to witness significant advances both in the introduction and clarification of underlying mechanisms and in the development of novel efficient tests that demonstrate clear evidence for the presence of dragon-kings in many systems. However, this positive view should be balanced by the fact that this remains a very delicate and difficult field, if only due to the scarcity of data as well as the extraordinary important implications with respect to hazard assessment, risk control and predictability.Comment: 20 page

The effect of accounting for biarticularity in hip flexor and hip extensor joint torque representations

Subject-specific torque-driven models have ignored biarticular effects at the hip. The aim of this study was to establish the contribution of monoarticular hip flexors and hip extensors to total hip flexor and total hip extensor joint torques for an individual and to investigate whether torque-driven simulation models should consider incorporating biarticular effects at the hip joint. Maximum voluntary isometric and isovelocity hip flexion and hip extension joint torques were measured for a single participant together with surface electromyography. Single-joint and two-joint representations were fitted to the collected torque data and used to determine the maximum voluntary joint torque capacity. When comparing two-joint and single-joint representations, the single-joint representation had the capacity to produce larger maximum voluntary hip flexion torque (larger by around 9% of maximum torque) and smaller maximum voluntary hip extension torque (smaller by around 33% of maximum torque) with the knee extended. Considering the range of kinematics found for jumping movements, the single-joint hip flexors had the capacity to produce around 10% additional torque, while the single joint hip extensors had about 70% of the capacity of the two-joint representation. Two-joint representations may overcome an over-simplification of single-joint representations by accounting for biarticular effects, while building on the strength of determining subject-specific parameters from measurements on the participant

Emergence of semi-localized Anderson modes in a disordered photonic crystal as a result of overlap probability

In this paper we study the effect of positional randomness on transmissional properties of a two dimensional photonic crystal as a function of a randomness parameter $\alpha$ ($\alpha=0$ completely ordered, $\alpha=1$ completely disordered). We use finite-difference time-domain~(FDTD) method to solve the Maxwell's equations in such a medium numerically. We consider two situations: first a 90\degr bent photonic crystal wave-guide and second a centrally pulsed photonic crystal micro-cavity. We plot various figures for each case which characterize the effect of randomness quantitatively. More specifically, in the wave-guide situation, we show that the general shape of the normalized total output energy is a Gaussian function of randomness with wavelength-dependent width. For centrally pulsed PC, the output energy curves display extremum behavior both as a function of time as well as randomness. We explain these effects in terms of two distinct but simultaneous effects which emerge with increasing randomness, namely the creation of semi-localized modes and the shrinking (and eventual destruction) of the photonic band-gaps. Semi-localized (i.e. Anderson localized) modes are seen to arise as a synchronization of internal modes within a cluster of randomly positioned dielectric nano-particles. The general trend we observe shows a sharp change of behavior in the intermediate randomness regime (i.e. $\alpha \approx 0.5$) which we attribute to a similar behavior in the underlying overlap probability of nano-particlesComment: New published version with a new title. This article is featured on the cover of the corresponding journal (Nov. issue of EJPB

Targeting Potential Drivers of COVID-19: Neutrophil Extracellular Traps

Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10-15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils-the ability to form neutrophil extracellular traps (NETs)-may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19