1,298 research outputs found
The inhibition of the vitamin k-dependent carboxylation of glutamyl residues in prothrombin by some copper complexes
Observation of electrolytic capacitor ageing behaviour for the purpose of prognostics
Electrolytic capacitors are an important
component within power electronics systems which are known to
exhibit poorer reliability compared to other components within
the system. In this paper, the changes in electrical parameters
(capacitance and equivalent series resistance) which occur as
electrolytic capacitors age are characterised at regular intervals
over the life of the capacitors. Ageing is observed under three
different bias conditions: no bias; constant voltage bias and
square wave excitation and at two different ambient
temperatures. The data captured within this work presents the
changes in capacitor properties from new, reaching to a point
which the capacitor parameters have changed sufficiently, such
that the capacitor can be considered to have failed. Such data will
prove valuable in the development of a system designed to
determine the state of health of a capacitor, or could be used to
predict its remaining useful lifetime
Dielectrophoresis of charged colloidal suspensions
We present a theoretical study of dielectrophoretic (DEP) crossover spectrum
of two polarizable particles under the action of a nonuniform AC electric
field. For two approaching particles, the mutual polarization interaction
yields a change in their respective dipole moments, and hence, in the DEP
crossover spectrum. The induced polarization effects are captured by the
multiple image method. Using spectral representation theory, an analytic
expression for the DEP force is derived. We find that the mutual polarization
effects can change the crossover frequency at which the DEP force changes sign.
The results are found to be in agreement with recent experimental observation
and as they go beyond the standard theory, they help to clarify the important
question of the underlying polarization mechanisms
Meaurement of Electrical Parameters of Electrolytic Capacitors Using Real-World Drive Waveforms for State-of-Health Determination
Electrolytic capacitors form an important part of
most drive systems. Consequently a method of determining the
state-of-health of these capacitors without having to remove them
from the system would be of value. In this paper a method of
achieving this is proposed. This is achieved by measuring the
current through and the voltage across the dc link capacitor within
a brushless dc motor drive; from these values the impedance
spectrum is calculated. From these measurements the capacitance
and resistance values of the capacitor are calculated. This
technique forms a useful prognostic tool for power electronic drive
systems where changes to these electrical parameters are a good
indicator of the state-of-health of the capacitor. Real-world results
taken from an experimental system demonstrate that increases in
capacitor resistance can be clearly observed
The use of ratiometric fluorescence measurements of the voltage sensitive dye Di-4-ANEPPS to examine action potential characteristics and drug effects on human induced pluripotent stem cell-derived cardiomyocytes
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and higher throughput platforms have emerged as potential tools to advance cardiac drug safety screening. This study evaluated the use of high bandwidth photometry applied to voltage-sensitive fluorescent dyes (VSDs) to assess drug-induced changes in action potential characteristics of spontaneously active hiPSC-CM. Human iPSC-CM from 2 commercial sources (Cor.4U and iCell Cardiomyocytes) were stained with the VSD di-4-ANEPPS and placed in a specialized photometry system that simultaneously monitors 2 wavebands of emitted fluorescence, allowing ratiometric measurement of membrane voltage. Signals were acquired at 10 kHz and analyzed using custom software. Action potential duration (APD) values were normally distributed in cardiomyocytes (CMC) from both sources though the mean and variance differed significantly (APD90: 229 ± 15 ms vs 427 ± 49 ms [mean ± SD, P < 0.01]; average spontaneous cycle length: 0.99 ± 0.02 s vs 1.47 ± 0.35 s [mean ± SD, P < 0.01], Cor.4U vs iCell CMC, respectively). The 10–90% rise time of the AP (Trise) was ∼6 ms and was normally distributed when expressed as 1/T2riseTrise2 in both cell preparations. Both cell types showed a rate dependence analogous to that of adult human cardiac cells. Furthermore, nifedipine, ranolazine, and E4031 had similar effects on cardiomyocyte electrophysiology in both cell types. However, ranolazine and E4031 induced early after depolarization-like events and high intrinsic firing rates at lower concentrations in iCell CMC. These data show that VSDs provide a minimally invasive, quantitative, and accurate method to assess hiPSC-CM electrophysiology and detect subtle drug-induced effects for drug safety screening while highlighting a need to standardize experimental protocols across preparations
A speech recognition strategy based on making acoustic evidence and phonetic knowledge explicit
We describe a prototype implementation of a representational approach to acoustic-phonetics in knowledge-based speech recognition. Our scheme is based on the 'Speech Sketch', a structure which enables acoustic evidence and phonetic knowledge to be represented in similar ways, so that like can be compared with like. The process of building the Speech Sketch begins with spectrogram image processing and goes on to exploit elementary phonetic constraints. A multiscale approach is used throughout. The process of interpreting the Speech Sketch makes use of an object-oriented phonetic knowledge base. Objects in the knowledge base can be matched against objects in the Speech Sketch in a manner directed by the incoming evidence. This technique promises to avoid a combinatorial explosion
Patterns-based Evaluation of Open Source BPM Systems: The Cases of jBPM, OpenWFE, and Enhydra Shark
In keeping with the proliferation of free software development initiatives and the increased interest in the business process management domain, many open source workflow and business process management systems have appeared during the last few years and are now under active development. This upsurge gives rise to two important questions: what are the capabilities of these systems? and how do they compare to each other and to their closed source counterparts? i.e. in other words what is the state-of-the-art in the area?. To gain an insight into the area, we have conducted an in-depth analysis of three of the major open source workflow management systems - jBPM, OpenWFE and Enhydra Shark, the results of which are reported here. This analysis is based on the workflow patterns framework and provides a continuation of the series of evaluations performed using the same framework on closed source systems, business process modeling languages and web-service composition standards. The results from evaluations of the three open source systems are compared with each other and also with the results from evaluations of three representative closed source systems - Staffware, WebSphere MQ and Oracle BPEL PM, documented in earlier works. The overall conclusion is that open source systems are targeted more toward developers rather than business analysts. They generally provide less support for the patterns than closed source systems, particularly with respect to the resource perspective which describes the various ways in which work is distributed amongst business users and managed through to completion
Study of neutron response and n-gamma discrimination by charge comparison method for small liquid scintillation detector
The study of the neutron response and n-gamma discrimination for small
(18x26x8) mm3 liquid scintillator BC501A (Bicron) detector was carried out by
digital charge comparison method. Three ranges of neutron energies were used:
uniform distribution from 0.95 MeV to 1.23 MeV, continuous spectra of AmBe
source and monoenergetic 16.2 MeV neutrons. The obtained results are compared
with those for cylindrical liquid scintillation detector (40 mm diameter, 60 mm
length) at the same energies of neutrons. A dramatic fall of the neutron
response function at 400 keVee for small detector at 16.2 MeV neutron energy
was measured. For (0.95 - 1.23) MeV neutron energy range such fall takes place
at 260 keVee. The greater slope of neutron locus at (0.95 - 1.23) MeV neutron
energy comparing to 16.2 MeV for both detectors is explained by longer tail of
pulse from proton recoils within (0.1-1.23) MeV energy range.Comment: submitted to Nuclear Instruments and Methods in Phys. Res. Sect.
Fabrication, Study of Optical Properties and Structure of Most Stable (CdP2)n Nanoclusters
CdP2 nanoclusters were fabricated by incorporation into pores of zeolite Na-X
and by laser ablation. Absorption and photoluminescence (PL) spectra of CdP2
nanoclusters in zeolite were measured at the temperatures of 4.2, 77 and 293 K.
Both absorption and PL spectra consist of two bands blue shifted with respect
to bulk crystal. We performed the calculations aimed to find the most stable
clusters in the size region up to size of the zeolite Na-X supercage. The most
stable clusters are (CdP2)6 and (CdP2)8 with binding energies of 9.30 eV and
10.10 eV per (CdP2)1 formula unit respectively. Therefore, we attributed two
bands observed in absorption and PL spectra to these stable clusters. The Raman
spectrum of CdP2 clusters in zeolite was explained to be originated from
(CdP2)6 and (CdP2)8 clusters as well. The PL spectrum of CdP2 clusters produced
by laser ablation consists of the asymmetric band with low-energy tail that has
been attributed to emission of both (CdP2)8 cluster and CdP2 microcrystals.Comment: Accepted for publication in Physica E: Low-dimensional Systems and
Nanostructure
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