The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). INTERPRETATION: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden

Níveis de cromo orgânico em rações para frangos de corte mantidos sob estresse por calor no período de um a 42 dias de idade Levels of dietary chromiumin rations for male broilers kept under heat stress from one to 42 days of age

Avaliou-se o efeito da suplementação de cromo sobre o desempenho e o rendimento de cortes de frangos, mantidos em ambiente de alta temperatura, no período de um a 42 dias de idade. Foram utilizados 400 frangos de corte, machos, da linhagem Cobb, em um delineamento experimental inteiramente ao acaso, com cinco tratamentos, 0, 350, 700, 1.050 e 1.400ppb de cromo na ração, oito repetições e 10 aves por repetição. Nos períodos de um a 21 e de um a 42 dias de idade, não houve influência dos tratamentos sobre o ganho de peso, o consumo de ração e a conversão alimentar das aves, mas observou-se que o consumo de cromo aumentou de forma linear. Os tratamentos não influenciaram os pesos absoluto e relativo de nenhum dos cortes, peito, coxa e sobrecoxa, avaliados aos 42 dias de idade. A suplementação de até 1.400ppb de cromo na ração não influenciou o desempenho e o rendimento de cortes nobres de frangos de corte mantidos em estresse por calor, no período de um a 42 dias de idade.<br>The effect of dietary organic chromium supplementation on the performance and yield of prime cuts of male broilers from one to 42 days of age reared under high environmental temperature was evaluated. Four-hundred Cobb male broilers, averaging 38±0.14g were distributed in a simple sample random design with five treatments (0; 350; 700; 1,050; and 1,400ppb of chromium in ration), eight replicates, and ten birds per replicates. In periods from one to 21 and from one to 42 days of age, the treatments did not influence the weight gain, the food intake, and the feed:gain ratio of the birds. However, the chromium intake increased in a linear way. No effect of both absolute and relative weights of all evaluated cuts (breast, thigh, and drumstick) was observed. The dietary chromium supplementation up to 1,400ppb did not influence the performance and the carcass traits of the male broilers kept under heat stress from one to 42 days of age

Efeitos da temperatura e da umidade relativa sobre o desempenho e o rendimento de cortes nobres de frangos de corte de 1 a 49 dias de idade Effects of temperature and relative humidity on performance and yield of noble cuts of broilers from 1 to 49 days old

Foram utilizados 180 pintos machos de 1 dia de idade, da linhagem Ross (peso inicial 43,0 &plusmn; 0,2 g) para avaliação dos efeitos de diferentes ambientes sobre o desempenho e as características de carcaça. As aves foram criadas no período de 1 a 49 dias de idade em um delineamento experimental inteiramente casualizado, com três ambientes (conforto térmico, calor seco e calor úmido), seis repetições por tratamento e dez aves por unidade experimental. As rações e a água foram fornecidas à vontade. O monitoramento da temperatura e da umidade relativa do ar de cada ambiente foi feito por meio de termômetros de bulbo seco e de globo negro. Os valores obtidos foram convertidos em valor único - Índice de Temperatura de Globo e Umidade (ITGU), para caracterização do ambiente. As temperaturas que caracterizaram os ambientes de conforto, de calor seco e de calor úmido foram, respectivamente, 25,1 &plusmn; 2,99; 35,0 &plusmn; 0,14 e 31,2 &plusmn; 1,82ºC e as umidades relativas registradas nos ambientes de calor seco e calor úmido foram, respectivamente, de 40 e 75%. Foram avaliados o consumo de ração, o ganho de peso e a conversão alimentar nos períodos de 1 a 21, 1 a 41 e 1 a 49 dias de idade. Ao final do experimento, as aves foram abatidas para avaliação dos pesos absolutos e do rendimento de carcaça e de cortes nobres (coxa, sobrecoxa e peito). O ambiente de calor influenciou negativamente o consumo de ração e o ganho de peso das aves em todos os períodos estudados, mas esse efeito foi mais acentuado nas aves mantidas em ambiente de calor úmido. O calor também influenciou negativamente os pesos absolutos de coxa, sobrecoxa e peito. Altas temperaturas prejudicam o desempenho e o rendimento de cortes nobres de frangos de corte de 1 a 49 dias de idade, de modo que esses efeitos são mais acentuados pelo aumento da umidade relativa do ar.<br>One hundred and eighty male Ross 1-d chicks averaging initial weight of 43.0 &plusmn; 0.2 g were used to evaluate the effects of different environments on performance and carcass characteristics. The experiment was analyzed as a completely randomized design with three environments (thermal comfort, dry heat and wet heat), six replicates of ten birds per experimental unity reared from 1 to 49 days old. Diets and water were fed ad libitum. The temperature and relative humidity control in each environment were measured by dry bulb and black globe thermometers. The values obtained were converted in a single value Black Globe Humidity and Temperature Index (BGHI) to characterize the environment. The temperatures that characterize the comfort, dry heat and wet heat were respectively: 25.1 &plusmn; 2.99, 35.0 &plusmn; 0.14, 31.2 &plusmn; 1.82ºC. The relative humidity recorded in dry and wet heat environments were respectively 40 and 75%. Feed intake, weight gain, feed:gain ratio in the periods from 1 to 21, 1 to 41 and 1 to 49 days of old were evaluated. In the end of the experiment, the birds were slaughtered for evaluation of absolute weights of noble cuts (thigh, drumstick and breast) and carcass yield. It was observed negative effect of heat environment on feed intake and weight gain in all periods and it was higher in birds on wet heat environment. Heat also influenced negatively absolute weights of thigh, drumstick and breast of birds. It was concluded that high temperatures impair the performance and yield of noble cuts of birds from 1 to 49 days old; in fact, these effects were higher with the greatest air relative humidity