62 research outputs found
Meta-analysis of STAT4 and IFIH1 polymorphisms in type 1 diabetes mellitus patients with autoimmune polyglandular syndrome type III
Type 1 diabetes mellitus (T1D) is an organ-specific autoimmune disease characterized by T-cell mediated self-destruction of insulin-producing \u3b2 cells in the pancreas. T1D patients are prone to develop other glandular autoimmune disorders, such as autoimmune thyroid disease that occurs simultaneously with autoimmune polyglandular syndrome type III (APSIII). Signal transducer and activator of transcription 4 (STAT4) is a well-known regulator of proinflammatory cytokines, and interferon-induced with helicase C domain 1 (IFIH1) is activated in the interferon type I response. Both genes have been examined separately in autoimmune diseases and, in this study, we assessed their joint role in T1D and APSIII. We conducted a case-control study, enrolling 173 T1D patients and 191 healthy controls from northeastern Brazil, to assess the distribution of the rs7574865 and rs3024839 SNPs in STAT4 and the rs3747517 and rs1990760 SNPs in IFIH1 in T1D and APSIII patients. Additionally, we conducted a meta-analysis with the rs7574865 SNP in STAT4 (1392 T1D patients and 1629 controls) and the rs1990760 SNP in IFIH1 (25092 T1D patients and 28544 controls) to examine their association with T1D. Distribution of STAT4 and IFIH1 allelic frequencies did not show statistically significant differences between T1D patients and controls in our study population; however, the meta-analysis indicated that SNPs in STAT4 and IFIH1 are associated with T1D worldwide. Our findings indicate that although STAT4 and IFIH1 SNPs are not associated with T1D in a Brazilian population, they might play a role in susceptibility to T1D on a larger worldwide scale
Diagnostic Ability Of Barrettâs Index to Detect Dysthyroid Optic Neuropathy Using Multidetector Computed Tomography
OBJECTIVES: The objective of this study was to evaluate the ability of a muscular index (Barrett's Index), calculated with multidetector computed tomography, to detect dysthyroid optic neuropathy in patients with Graves' orbitopathy. METHODS: Thirty-six patients with Graves' orbitopathy were prospectively studied and submitted to neuro-ophthalmic evaluation and multidetector computed tomography scans of the orbits. Orbits were divided into two groups: those with and without dysthyroid optic neuropathy. Barrett's index was calculated as the percentage of the orbit occupied by muscles. Sensitivity and specificity were determined for several index values. RESULTS: Sixty-four orbits (19 with and 45 without dysthyroid optic neuropathy) met the inclusion criteria for the study. The mean Barrett's index values (± SD) were 64.47% ± 6.06% and 49.44% ± 10.94%in the groups with and without dysthyroid optic neuropathy, respectively (p<0.001). Barrett's index sensitivity ranged from 32% to 100%, and Barrett's index specificity ranged from 24% to 100%. The best combination of sensitivity and specificity was 79%/72% for BI=60% (odds ratio: 9.2). CONCLUSIONS: Barrett's Index is a useful indicator of dysthyroid optic neuropathy and may contribute to early diagnosis and treatment. Patients with a Barrett's index >60% should be carefully examined and followed for the development of dysthyroid optic neuropathy
Quality Of Sleep And Quality Of Life In Adolescents Infected With Human Immunodeficiency Virus [qualidade Do Sono E Qualidade De Vida Em Adolescentes Infectados Pelo VĂrus Da ImunodeficiĂȘncia Humana]
Objectives: To assess sleep characteristics of adolescents infected by HIV, and to ascertain whether psychosocial aspects are associated to the quality of sleep. Methods: A cross-sectional study assessing 102 HIV-infected adolescents of both genders, aged between 10 and 20 years-old and 120 Controls. Data collection was performed by applying the Sleep Disturbance Scale for Children, the Epworth Sleepiness Scale, and the Pediatric Quality of Life Inventory. Results: A sleep disturbance prevalence of 77.4% was found in patients, and a 75% prevalence in controls, and there was correlation between quality of sleep and of life. HIV-infected adolescents scored higher for sleep breathing disorders and had higher prevalence of excessive daytime sleepiness. Conclusions: HIV-infected adolescents had similar quality of sleep compared to healthy adolescents. This may be explained by the steady improvements in daily living as a result of successful anti-retroviral therapy, and by the vulnerability that affects Brazilian adolescents living in major urban centers.706422427Carskadon, M.A., Sleep in adolescents: The perfect storm (2011) Pediatr Clin North Am, 58, pp. 637-647Owens, J.A., Belon, K., Moss, P., Impact of delaying school start time on adolescent sleep, mood, and behavior (2010) Arch Pediatr Adolesc Med, 164, pp. 608-614de-la-Llata-Romero, M., Castorena-Maldonado, A., Corsi-Cabrera, M., Sleep medicine: Development, contributions and perspectives Report of the work group on sleep medicine (2011) Rev Invest Clin, 63, pp. 90-99Mindell, J.A., Owens, J., Alves, R., Give children and adolescents the gift of a good night's sleep: A call to action (2011) Sleep Med, 12, pp. 203-204Moore, M., Meltzer, L.J., The sleepy adolescent: Causes and consequences of sleepiness in teens (2008) Paediatr Respir Rev, 9, pp. 114-120(2010) Global report: UNAIDS report on the global AIDS epidemic, , http://www.unaids.org/globalreport/documents/20101123_GlobalReport_full_en.pdf, Joint United Nations Programme on HIV/AIDS (UNAIDS), [cited 16 May 2011]. Available at(2011) MinistĂ©rio da SaĂșde 2010, , http://www.aids.gov.br/publicacao/boletim-epidemiologico-2010, Brasil, Departamento de DST, Aids e Hepatites Virais. Boletim EpidemiolĂłgico AIDS 2010 (versĂŁo preliminar). [cited 21 March]. Available atHazra, R., Siberry, G.K., Mofenson, L.M., Growing up with HIV: Children, adolescents, and young adults with perinatally acquired HIV infection (2010) Ann Rev Med, 61, pp. 169-185Ramos, A.N., Matida, L.H., Hearst, N., Heukelbach, J., AIDS in Brazilian children: History, surveillance, antiretroviral therapy, and epidemiologic transition, 1984-2008 (2011) AIDS Patient Care STDS, 25, pp. 245-255Franck, L.S., Johnson, L.M., Lee, K., Sleep disturbances in children with human immunodeficiency virus infection (1999) Pediatrics, 104, pp. 1-5Reid, S., Dwyer, J., Insomnia in HIV Infection: A systematic review of prevalence, correlates and management (2005) Psychosomatic Med, 67, pp. 260-269Rocha, C.R.S., Rossini, S., ReimĂŁo, R., Sleep disorders in high school and pre-university students (2010) Arq Neuropsiquiatr, 68, pp. 903-907Mesquita, G., ReimĂŁo, R., Nightly use of computer by adolescents: Its effect on quality of sleep (2007) Arq Neuropsiquiatr, 65, pp. 428-432Varni, J.W., Seid, M., Rode, C.A., The PedsQL: Measurement model for the pediatric quality of life inventory (1999) Med Care, 37, pp. 126-139(2009) MinistĂ©rio da SaĂșde, , Brasil, Secretaria de VigilĂąncia em SaĂșde. Programa Nacional de DST e Aids. RecomendaçÔes para Terapia Antirretroviral em Crianças e Adolescentes Infectados polo HIV. Manual de bolso. MinistĂ©rio da SaĂșde, Secretaria de VigilĂąncia em SaĂșde, Programa Nacional de DST e Aids. BrasĂlia: MinistĂ©rio da SaĂșdeBruni, O., Salvatori, O., Guidetti, V., The sleep disturbance scale for children (SDSC) Construction and validation of an instrument to evaluate sleep disturbances in childhood and adolescence (1996) J Sleep Res, 5, pp. 251-261Johns, M.W., A new method for measuring daytime sleepiness: The Epworth sleepiness scale (1991) Sleep, 14, pp. 540-545Ferreira, V.R., Carvalho, L.B.C., Ruotolo, F., Morais, J.F., Prado, L.B.F., Prado, G.F., Sleep disturbance scale for children: Translation, cultural adaptation and validation (2009) Sleep Med, 10, pp. 457-463Bertolazi, N.A., Fagondes, S.C., Hoff, L.S., Pedro, V.D., Barreto, S.S.M., Johns, M.W., Validação da escala de sonolĂȘncia de Epworth em portuguĂȘs para uso no Brasil (2009) J Bras Pneumol, 35, pp. 877-883Klatchoian, D.A., Len, C.A., Terreri, M.T., Quality of life of children and adolescents from SĂŁo Paulo: Reliability and validity of the Brazilian version of the Pediatric Quality of Life Inventory TM version 4.0 Generic Core Scales (2008) J Pediatr (Rio J), 84, pp. 308-315Potasz, C., Juliano, M.L., Varela, M.J., Prevalence of sleep disorders in children of a public hospital in SĂŁo Paulo (2010) Arq Neuropsiquiatr, 68, pp. 235-241Carotenuto, M., Bruni, O., Santoro, N., Giudice, E.M., Perrone, L., Pascotto, A., Waist circumference predicts the occurrence of sleep-disordered breathing in obese children and adolescents: A questionnaire-based study (2006) Sleep Med, 7, pp. 357-361Ramalho, L.C.B., Gonçalves, E.M., Carvalho, W.R.G., Abnormalities in body composition and nutritional status in HIV-infected children and adolescents on antiretroviral therapy (2011) Int J STD AIDS, 22, pp. 453-456Chan, E.Y., Ng, D.K., Chan, C.H., Modified Epworth Sleepiness Scale in Chinese children with obstructive sleep apnea: A retrospective study (2009) Sleep Breath, 13, pp. 59-63Melendres, M.C., Lutz, J.M., Rubin, E.D., Marcus, C.L., Daytime sleepiness and hyperactivity in children with suspected sleep-disordered breathing (2004) Pediatrics, 114, pp. 768-775van Litsenburg, R.R., Huisman, J., Hoogerbrugge, P.M., Egeler, R.M., Kaspers, G.J., Gemke, R.J., Impaired sleep affects quality of life in children during maintenance treatment for acute lymphoblastic leukemia: An exploratory study (2011) Health Qual Life Outcomes, 18, pp. 9-25Erickson, J.M., Beck, S.L., Christian, B.R., Fatigue, sleep-wake disturbances, and quality of life in adolescents receiving chemotherapy (2011) J Pediatr Hematol Oncol, 33, pp. 17-25Mitchell, R.B., Boss, E.F., Pediatric obstructive sleep apnea in obese and normal-weight children: Impact of adenotonsillectomy on quality-of-life and behavior (2009) Dev Neuropsychol, 34, pp. 650-661Crabtree, V.M., Varni, J.W., Gozal, D., Health-related quality of life and depressive symptoms in children with suspected sleep-disordered breathing (2004) Sleep, 27, pp. 1131-1138Ong, L.C., Yang, W.W., Wong, S.W., Alsissiq, F., Khu, Y.S., Sleep habits and disturbances in Malaysian children with epilepsy (2010) J Paediatr Child Health, 46, pp. 80-8
Crescimento vascular em membrana do saco vitelĂnico e desenvolvimento embrionĂĄrio de codornas japonesas (Coturnix japonica) expostas a campo magnĂ©tico de baixa frequĂȘncia
Morcegos (mammalia, chiroptera) em fragmentos florestais urbanos no municĂpio de Juiz de Fora, Minas Gerais, Sudeste do Brasil
A aplicação precoce de nitrogĂȘnio em cobertura nĂŁo aumenta o rendimento de grĂŁos do trigo cultivado na presença do alumĂnio
- âŠ