Extinctions and Correlations for Uniformly Discrete Point Processes with Pure Point Dynamical Spectra

The paper investigates how correlations can completely specify a uniformly discrete point process. The setting is that of uniformly discrete point sets in real space for which the corresponding dynamical hull is ergodic. The first result is that all of the essential physical information in such a system is derivable from its $n$-point correlations, $n= 2, 3, >...$. If the system is pure point diffractive an upper bound on the number of correlations required can be derived from the cycle structure of a graph formed from the dynamical and Bragg spectra. In particular, if the diffraction has no extinctions, then the 2 and 3 point correlations contain all the relevant information.Comment: 16 page

Composite grading algorithm for the National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)

Background: The Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events is an item library designed for eliciting patient-reported adverse events in oncology. For each adverse event, up to three individual items are scored for frequency, severity, and interference with daily activities. To align the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events with other standardized tools for adverse event assessment including the Common Terminology Criteria for Adverse Events, an algorithm for mapping individual items for any given adverse event to a single composite numerical grade was developed and tested. Methods: A five-step process was used: (1) All 179 possible Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events score combinations were presented to 20 clinical investigators to subjectively map combinations to single numerical grades ranging from 0 to 3. (2) Combinations with <75% agreement were presented to investigator committees at a National Clinical Trials Network cooperative group meeting to gain majority consensus via anonymous voting. (3) The resulting algorithm was refined via graphical and tabular approaches to assure directional consistency. (4) Validity, reliability, and sensitivity were assessed in a national study dataset. (5) Accuracy for delineating adverse events between study arms was measured in two Phase III clinical trials (NCT02066181 and NCT01522443). Results: In Step 1, 12/179 score combinations had <75% initial agreement. In Step 2, majority consensus was reached for all combinations. In Step 3, five grades were adjusted to assure directional consistency. In Steps 4 and 5, composite grades performed well and comparably to individual item scores on validity, reliability, sensitivity, and between-arm delineation. Conclusion: A composite grading algorithm has been developed and yields single numerical grades for adverse events assessed via the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events, and can be useful in analyses and reporting

Scattering of elastic waves by periodic arrays of spherical bodies

We develop a formalism for the calculation of the frequency band structure of a phononic crystal consisting of non-overlapping elastic spheres, characterized by Lam\'e coefficients which may be complex and frequency dependent, arranged periodically in a host medium with different mass density and Lam\'e coefficients. We view the crystal as a sequence of planes of spheres, parallel to and having the two dimensional periodicity of a given crystallographic plane, and obtain the complex band structure of the infinite crystal associated with this plane. The method allows one to calculate, also, the transmission, reflection, and absorption coefficients for an elastic wave (longitudinal or transverse) incident, at any angle, on a slab of the crystal of finite thickness. We demonstrate the efficiency of the method by applying it to a specific example.Comment: 19 pages, 5 figures, Phys. Rev. B (in press

Localizability of Tachyonic Particles and Neutrinoless Double Beta Decay

The quantum field theory of superluminal (tachyonic) particles is plagued with a number of problems, which include the Lorentz non-invariance of the vacuum state, the ambiguous separation of the field operator into creation and annihilation operators under Lorentz transformations, and the necessity of a complex reinterpretation principle for quantum processes. Another unsolved question concerns the treatment of subluminal components of a tachyonic wave packets in the field-theoretical formalism, and the calculation of the time-ordered propagator. After a brief discussion on related problems, we conclude that rather painful choices have to be made in order to incorporate tachyonic spin-1/2 particles into field theory. We argue that the field theory needs to be formulated such as to allow for localizable tachyonic particles, even if that means that a slight unitarity violation is introduced into the S matrix, and we write down field operators with unrestricted momenta. We find that once these choices have been made, the propagator for the neutrino field can be given in a compact form, and the left-handedness of the neutrino as well as the right-handedness of the antineutrino follow naturally. Consequences for neutrinoless double beta decay and superluminal propagation of neutrinos are briefly discussed.Comment: 12 pages, 5 figure

Missing data strategies for the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) in Alliance A091105 and COMET-2

Purpose: Missing scores complicate analysis of the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) because patients with and without missing scores may systematically differ. We focus on optimal analysis methods for incomplete PRO-CTCAE items, with application to two randomized, double-blind, placebo-controlled, phase III trials. Methods: In Alliance A091105 and COMET-2, patients completed PRO-CTCAE items before randomization and several times post-randomization (N = 64 and 107, respectively). For each trial, we conducted between-arm comparisons on the PRO-CTCAE via complete-case two-sample t-tests, mixed modeling with contrast, and multiple imputation followed by two-sample t-tests. Because interest lies in whether CTCAE grades can inform missing PRO-CTCAE scores, we performed multiple imputation with and without CTCAE grades as auxiliary variables to assess the added benefit of including them in the imputation model relative to only including PRO-CTCAE scores across all cycles. Results: PRO-CTCAE completion rates ranged from 100.0 to 71.4% and 100.0 to 77.1% across time in A091105 and COMET-2, respectively. In both trials, mixed modeling and multiple imputation provided the most similar estimates of the average treatment effects. Including CTCAE grades in the imputation model did not consistently narrow confidence intervals of the average treatment effects because correlations for the same PRO-CTCAE item between different cycles were generally stronger than correlations between each PRO-CTCAE item and its corresponding CTCAE grade at the same cycle. Conclusion: For between-arm comparisons, mixed modeling and multiple imputation are informative techniques for handling missing PRO-CTCAE scores. CTCAE grades do not provide added benefit for informing missing PRO-CTCAE scores. ClinicalTrials.gov Identifiers: NCT02066181 (Alliance A091105); NCT01522443 (COMET-2)

It's not only about technology, it's about people: interpersonal skills as a part of the IT education.

Proceedings of: Second World Summit on the Knowledge Society (WSKS 2009), Chania, Crete, Greece, September 16-18, 2009.The importance of what have been termed the "soft skills" for the professional development of IT professionals is beyond any doubt. Taking account of this circumstance, the objective of the current research may be phrased as two separate questions. In the first place, determining the importance which IT related degree students place on these types of competencies for their professional future. In the second place, the importance which the development of the mentioned competencies has been given during their studies. The realization of an empirical study has fulfilled the two objectives described. The results demonstrate, on the one side, the moderate relevance which students assign to interpersonal competencies, especially emotional competencies, in contrast to the international curricular recommendations and studies concerning labor markets. On the other hand, the results indicate the scarce emphasis which lecturers have placed on the development of such competencies.Publicad

Emergence of semi-localized Anderson modes in a disordered photonic crystal as a result of overlap probability

In this paper we study the effect of positional randomness on transmissional properties of a two dimensional photonic crystal as a function of a randomness parameter $\alpha$ ($\alpha=0$ completely ordered, $\alpha=1$ completely disordered). We use finite-difference time-domain~(FDTD) method to solve the Maxwell's equations in such a medium numerically. We consider two situations: first a 90\degr bent photonic crystal wave-guide and second a centrally pulsed photonic crystal micro-cavity. We plot various figures for each case which characterize the effect of randomness quantitatively. More specifically, in the wave-guide situation, we show that the general shape of the normalized total output energy is a Gaussian function of randomness with wavelength-dependent width. For centrally pulsed PC, the output energy curves display extremum behavior both as a function of time as well as randomness. We explain these effects in terms of two distinct but simultaneous effects which emerge with increasing randomness, namely the creation of semi-localized modes and the shrinking (and eventual destruction) of the photonic band-gaps. Semi-localized (i.e. Anderson localized) modes are seen to arise as a synchronization of internal modes within a cluster of randomly positioned dielectric nano-particles. The general trend we observe shows a sharp change of behavior in the intermediate randomness regime (i.e. $\alpha \approx 0.5$) which we attribute to a similar behavior in the underlying overlap probability of nano-particlesComment: New published version with a new title. This article is featured on the cover of the corresponding journal (Nov. issue of EJPB

Sorafenib for advanced and refractory desmoid tumors

BACKGROUND Desmoid tumors (also referred to as aggressive fibromatosis) are connective tissue neoplasms that can arise in any anatomical location and infiltrate the mesentery, neurovascular structures, and visceral organs. There is no standard of care. METHODS In this double-blind, phase 3 trial, we randomly assigned 87 patients with progressive, symptomatic, or recurrent desmoid tumors to receive either sorafenib (400- mg tablet once daily) or matching placebo. Crossover to the sorafenib group was permitted for patients in the placebo group who had disease progression. The primary end point was investigator-assessed progression-free survival; rates of objective response and adverse events were also evaluated. RESULTS With a median follow-up of 27.2 months, the 2-year progression-free survival rate was 81% (95% confidence interval [CI], 69 to 96) in the sorafenib group and 36% (95% CI, 22 to 57) in the placebo group (hazard ratio for progression or death, 0.13; 95% CI, 0.05 to 0.31; P<0.001). Before crossover, the objective response rate was 33% (95% CI, 20 to 48) in the sorafenib group and 20% (95% CI, 8 to 38) in the placebo group. The median time to an objective response among patients who had a response was 9.6 months (interquartile range, 6.6 to 16.7) in the sorafenib group and 13.3 months (interquartile range, 11.2 to 31.1) in the placebo group. The objective responses are ongoing. Among patients who received sorafenib, the most frequently reported adverse events were grade 1 or 2 events of rash (73%), fatigue (67%), hypertension (55%), and diarrhea (51%). CONCLUSIONS Among patients with progressive, refractory, or symptomatic desmoid tumors, sorafenib significantly prolonged progression-free survival and induced durable responses