Intra-articular administration of lidocaine plus adrenaline in dogs : pharmacokinetic profile and evaluation of toxicity in vivo and in vitro

The aim of this study was to evaluate the safety of intra-articular (IA) lidocaine plus adrenaline for improving peri-operative analgesia in anaesthetised dogs undergoing arthroscopy of the elbow. A solution of lidocaine (L) 1.98% plus adrenaline 1:100.000 was administered via the IA route and its safety evaluated in terms of cardio- neuro- and chondro-toxicity. No bradycardia or hypotension was recorded from induction to the last observational time point. Signs of toxicity of the nervous system could have been masked by the general anaesthesia but lidocaine concentrations detected in the blood were lower than those thought to be capable of producing toxicity. The assessment of in vitro chondrotoxicity showed a dose- and time-dependent effect of lidocaine on the viability of articular cells. Adrenaline appeared to reduce the chondrotoxicity of 1% lidocaine, following an exposure of up to 30 min

Metamorphosis and Taxonomy of Andreev Bound States

We analyze the spatial and energy dependence of the local density of states in a SNS junction. We model our system as a one-dimensional tight-binding chain which we solve exactly by numerical diagonalization. We calculate the dependence of the Andreev bound states on position, phase difference, gate voltage, and coupling with the superconducting leads. Our results confirm the physics predicted by certain analytical approximations, but reveal a much richer set of phenomena beyond the grasp of these approximations, such as the metamorphosis of the discrete states of the normal link (the normal bound states) into Andreev bound states as the leads become superconducting.Comment: 23 pages, 15 figure

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Nucleation of superconductivity in finite metallic multilayers: effect of the simmetry

The influence of the finite dimensions of superconducting metallic multilayers on H-T phase diagram is studied. It is established that the geometrical symmetry of the samples determines crucially the $H_{c2\vert \vert }(T)$ dependencies. For samples where the symmetry plane is in the middle of the superconducting layer the $H_{c2\vert \vert }$ values are, for temperatures close to Tc, larger than the $H_{c2\vert \vert }$ values of the samples for which the symmetry plane lies in the middle of the normal layer. The results are analysed on the basis of the Ginzburg-Landau approach and are explained by considering the different symmetry of the wave function describing the system. The experimental results are in good agreement with the elaborated model, which takes into account the actual symmetry of the samples

Intra-articular administration of lidocaine in anaesthetized dogs: pharmacokinetic profile and safety on cardiovascular and nervous systems

The intra-articular administration of lidocaine is a frequent practice in human orthopaedic surgical procedures, but an eventual absorption of the drug into the bloodstream can lead to toxicity, mainly concerning the central nervous system and the cardiovascular systems. The purpose of this study was to determine the pharmacokinetic profile and the safety, in terms of cardiovascular and CNS toxicity, of lidocaine after intra-articular administration to anesthetized dogs undergoing arthroscopy. Lidocaine 2% was administered to eight dogs before surgery in differing amounts, depending on the volume of the joints involved, and blood samples were taken at predetermined time points. The maximum serum concentration of lidocaine ranged from 0.50 to 3.01 \u3bcg/mL (mean \ub1 SD: 2.18 \ub1 0.91 \u3bcg/mL), and the time to reach it was 28.75 \ub1 15.74 min. No signs of cardiac toxicity were detected during the entire procedure, and possible signs of CNS toxicity were masked by the anaesthesia. However, concentrations reported in literature as responsible for neurotoxicity in dog were achieved in three of eight investigated subjects. Pending further studies, veterinarians should consider the possibility of side effects occurring following the intra-articular administration of local anaesthetics