Relevance of Angiotensin-(1-7) and its receptor Mas in pneumonia caused by Influenza virus and post-influenza pneumococcal infection

Resolution failure of exacerbated inflammation triggered by Influenza A virus (IAV) prevents return of pulmonary homeostasis and survival, especially when associated with secondary pneumococcal infection. Therapeutic strategies based on pro-resolving molecules have great potential against acute inflammatory diseases. Angiotensin-(1-7) [Ang-(1-7)] is a pro-resolving mediator that acts on its Mas receptor (MasR) to promote resolution of inflammation. We investigated the effects of Ang-(1-7) and the role of MasR in the context of primary IAV infection and secondary pneumococcal infection and evaluated pulmonary inflammation, virus titers and bacteria counts, and pulmonary damage. Therapeutic treatment with Ang-(1-7) decreased neutrophil recruitment, lung injury, viral load and morbidity after a primary IAV infection. Ang-(1-7) induced apoptosis of neutrophils and efferocytosis of these cells by alveolar macrophages, but had no direct effect on IAV replication in vitro. MasR-deficient (MasR(-/-)) mice were highly susceptible to IAV infection, displaying uncontrolled inflammation, increased viral load and greater lethality rate, as compared to WT animals. Ang-(1-7) was not protective in MasR(-/-) mice. Interestingly, Ang-(1-7) given during a sublethal dose of IAV infection greatly reduced morbidity associated with a subsequent S. pneumoniae infection, as seen by decrease in the magnitude of neutrophil influx, number of bacteria in the blood leading to a lower lethality. Altogether, these results show that Ang-(1-7) is highly protective against severe primary IAV infection and protects against secondary bacterial infection of the lung. These effects are MasR-dependent. Mediators of resolution of inflammation, such as Ang-(1-7), should be considered for the treatment of pulmonary viral infections

The DREAMS Experiment Onboard the Schiaparelli Module of the ExoMars 2016 Mission: Design, Performances and Expected Results

The first of the two missions foreseen in the ExoMars program was successfully launched on 14th March 2016. It included the Trace Gas Orbiter and the Schiaparelli Entry descent and landing Demonstrator Module. Schiaparelli hosted the DREAMS instrument suite that was the only scientific payload designed to operate after the touchdown. DREAMS is a meteorological station with the capability of measuring the electric properties of the Martian atmosphere. It was a completely autonomous instrument, relying on its internal battery for the power supply. Even with low resources (mass, energy), DREAMS would be able to perform novel measurements on Mars (atmospheric electric field) and further our understanding of the Martian environment, including the dust cycle. DREAMS sensors were designed to operate in a very dusty environment, because the experiment was designed to operate on Mars during the dust storm season (October 2016 in Meridiani Planum). Unfortunately, the Schiaparelli module failed part of the descent and the landing and crashed into the surface of Mars. Nevertheless, several seconds before the crash, the module central computer switched the DREAMS instrument on, and sent back housekeeping data indicating that the DREAMS sensors were performing nominally. This article describes the instrument in terms of scientific goals, design, working principle and performances, as well as the results of calibration and field tests. The spare model is mature and available to fly in a future mission

The colour and stereo surface imaging system (CaSSIS) for the ExoMars Trace Gas Orbiter

The Colour and Stereo Surface Imaging System (CaSSIS) is the main imaging system onboard the European Space Agency’s ExoMars Trace Gas Orbiter (TGO) which was launched on 14 March 2016. CaSSIS is intended to acquire moderately high resolution (4.6 m/pixel) targeted images of Mars at a rate of 10–20 images per day from a roughly circular orbit 400 km above the surface. Each image can be acquired in up to four colours and stereo capability is foreseen by the use of a novel rotation mechanism. A typical product from one image acquisition will be a 9.5 km×∼45 km swath in full colour and stereo in one over-flight of the target thereby reducing atmospheric influences inherent in stereo and colour products from previous high resolution imagers. This paper describes the instrument including several novel technical solutions required to achieve the scientific requirements