109 research outputs found

    Two methods of preparing thin sections of wet soil from sediments in a marine intertidal zone in the Oosterschelde (the Netherlands).

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    Thin sections of immature marine sediments in the intertidal zone were prepared by replacement of the soil moisture by acetone, or by freeze drying, prior to embedding and sectioning. Replacement sections were of good quality and did not show artificial cracking. However preparation was time consuming and both salts and humic substances were removed by the acetone. Freeze dried sections were of poorer quality, but satisfactory. Artificial cracking was apparent. Preparation time was shorter but few salts were removed. (Abstract retrieved from CAB Abstracts by CABI’s permission

    Woodlands of the past: results of the excavation of Zwolle-Stadshagen (The Netherlands) II, Development of the paleo-landscape in its hydrological context

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    Micromorphology was used to reconstruct the paleo-landscape in which a woodland had grown between about 200 BC and 600 AD in Zwolle-Stadshagen. This is the second article of a set of five on the integrated reconstruction of this woodland of the past

    Intellectual and motor development of young adults with congenital hypothyroidism diagnosed by neonatal screening

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    Contains fulltext : 35756.pdf (publisher's version ) (Open Access)CONTEXT: Long-term follow-up data on cognitive and motor functioning in adult patients with congenital hypothyroidism, diagnosed by neonatal screening, are scarce. Hence, it is still unclear whether the frequently reported cognitive and motor deficits observed during childhood persist in adulthood. OBJECTIVE: The objective of this study was to examine cognitive and motor functioning in young adults with congenital hypothyroidism, born in the first 2 yr after the introduction of the Dutch neonatal screening program. DESIGN/SETTING/PATIENTS: Seventy patients were tested (mean age, 21.5 yr); 49 of them were previously tested at 9.5 yr. The median age at the start of treatment was 28 d (range, 4-293 d). Congenital hypothyroidism was classified as severe, moderate, or mild, according to pretreatment T(4) concentrations. MAIN OUTCOME MEASUREMENT: The main outcome measurement was the influence of the severity of congenital hypothyroidism and age at which T(4) supplementation was started on cognitive and motor outcome. RESULTS: Patients, particularly those with severe congenital hypothyroidism, had significantly higher (i.e. worse) motor scores (total score, 7.8; ball skills, 2.0; balance, 4.1) compared with controls (total score, 3.2; ball skills, 0.7; balance, 1.1), and lower full-scale (95.8), verbal (96.4), and performance (95.6) intelligence quotient (IQ) scores than the normal population. No significant change in IQ from childhood to adulthood was found, and for the majority of patients, motor score classification remained the same. The severity of congenital hypothyroidism, but not the starting day of treatment, was correlated with IQ and motor scores. CONCLUSIONS: It is concluded that the severity of congenital hypothyroidism, but not the timing of treatment initiation, is an important factor determining long-term cognitive and motor outcome. Clearly, detrimental effects on developmental outcome in patients with congenital hypothyroidism persist over time
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