‘Pure Feelings, Noble Aspirations and Generous Ideas’ : the Martí–Dana Friendship and the Cuban War of independence

This article considers the friendship between the Cuban leader José Martí and the US journalist Charles Anderson Dana in relation to questions of transnationalism, print culture, modernist aesthetics, and the politics of dissent during the era of the Cuban War of Independence (1895–8). It investigates the radical potential and aesthetic difficulties of rendering genuine affection in print at a time in which American friendliness towards Cuba often served to mask imperialist intentions. I offer a reading of Charles Dana’s obituary for José Martí as a text that destabilizes assumptions about Cuban–American relations in the late nineteenth century by presenting an alternative political vision that incorporated the possibility of an autonomous Cuban subjectivity. In doing this, I resurrect the work of Charles Dana as a proto-modernist alternative vision of US culture that deployed the history of American Transcendentalism within the forms of late-nineteenth-century print media to register his opposition to the rise of modern press magnates such as W.R. Hearst and Joseph Pulitzer. This article challenges dominant narratives on two fronts: first, by suggesting an alternative to normative accounts of the development of the late-nineteenth-century commercial press; second, by exploring the mutual interpenetration of Latin American and US American radical history

An assessment of the performance of grip enhancing agents used in sports applications

The performances of four grip enhancing agents, powdered and liquid chalk, rosin and Venice turpentine, were assessed using a bespoke finger friction rig and compared against an agent-free finger. The effectiveness of these agents was measured in dry, damp and wet conditions, to simulate the different environments in which the agents are used. The tests were first done on a polished steel surface and then the powdered and liquid chalk and agent-free finger were tested on sandstone. The tests on the steel showed that in a dry condition, only the Venice turpentine significantly increased the coefficient of friction, compared to no application of agent, with the rosin and powdered chalk actually decreasing the coefficient of friction. It is thought that the reduction in the coefficient of friction is caused by the solid particles acting as a lubricant between the two surfaces. When the fingers were wet, only the granular powder-based agents increased the coefficient of friction. This is because the Venice turpentine cannot adhere well to a wet finger, and therefore is not as effective. When the surface is wet, there is very little difference between the agents due to the water separating the finger surface from the steel. The tests on the sandstone showed no real difference between the lubricants or the different conditions, except for the dry, chalk-free finger, which had a decreased coefficient of friction due to the lubricating properties of the sandstone particles. These results highlight that the use of grip enhancing agents should take into account the moisture in the contact, as in dry conditions, the grip may be optimum when there is no agent used. It also shows that in different sports, different grip enhancing agents should be used

Design and realisation of a MZI type polymer based high speed EO-modulator

We designed a 20 GHz Mach Zehnder interferometric EO-modulator based on a new developed polyesterimide. Measurements show a V/sub /spl pi// of 7.5 V, an insertion loss of 11 dB and an extinction ratio exceeding 20 dB for an interaction length of 2 cm

Treatment regimens and outcomes in severe and moderate haemophilia A in the UK: The THUNDER study

Introduction: The THUNDER study provides an analysis of treatment patterns and outcomes in UK patients with severe or moderate haemophilia A (SHA/MHA) in 2015. Methods: Patients with SHA or MHA registered with the UK National Haemophilia Database (NHD) were segregated by severity, inhibitor status and age. Haemophilia joint health score (HJHS) was derived from NHD records and treatment regimen and annualized bleed/joint‐bleed rate (ABR/AJBR) from Haemtrack (HT) in HT‐compliant patients. Results: We report 1810 patients with SHA and 864 with MHA. Prophylaxis was used in 94.9% (n = 130/137) of HT‐compliant children <12 years with SHA, falling to 74.1% (n = 123/166) aged ≥40 years. Median ABR increased with age (1.0, IQR 0.0‐5.0, <12 years; 3.0 IQR, 1.0‐8.0, ≥40 years). Inhibitors were present in 159 (8.8%) SHA and 34 (3.9%) MHA. Median ABR increased from 2.0 (<12 years) to 21.(≥40 years) in SHA inhibitor patients using prophylaxis. Prophylaxis was used by 68.8% of HT‐compliant MHA patients (n = 106) (median FVIII baseline 0.01 IU/mL) associated with a median (IQR) ABR of 3.0 (1.0‐7.0). Median HJHS (n = 453) increased with age in SHA and MHA. Median (IQR) HJHS was higher in SHA inhibitor (17.0, 0.0‐64.5) than non‐ or past inhibitor patients (7.0, 0.0‐23.0). Conclusions: Increasing ABR with age persists despite current prophylaxis regimens.SHA and MHA had similar ABR/AJBR and HJHS, leading to a suspicion that a subgroup of MHA may be relatively undertreated. More intensive prophylaxis may improve outcomes, but this requires further study

Spin Two Glueball Mass and Glueball Regge Trajectory from Supergravity

We calculate the mass of the lowest lying spin two glueball in N=1 super Yang-Mills from the dual Klebanov-Strassler background. We show that the Regge trajectory obtained is linear; the 0++, 1-- and 2++ states lie on a line of slope 0.23 -measured in units of the conifold deformation. We also compare mass ratios with lattice data and find agreement within one standard deviation.Comment: 17 pages, 2 figure

The changing trend in nitrate concentrations in major aquifers due to historical nitrate loading from agricultural land across England and Wales from 1925 to 2150

Nitrate is necessary for agricultural productivity, but can cause considerable problems if released into aquatic systems. Agricultural land is the major source of nitrates in UK groundwater. Due to the long time-lag in the groundwater system, it could take decades for leached nitrate from the soil to discharge into freshwaters. However, this nitrate time-lag has rarely been considered in environmental water management. Against this background, this paper presents an approach to modelling groundwater nitrate at the national scale, to simulate the impacts of historical nitrate loading from agricultural land on the evolution of groundwater nitrate concentrations. An additional process-based component was constructed for the saturated zone of significant aquifers in England and Wales. This uses a simple flow model which requires modelled recharge values, together with published aquifer properties and thickness data. A spatially distributed and temporally variable nitrate input function was also introduced. The sensitivity of parameters was analysed using Monte Carlo simulations. The model was calibrated using national nitrate monitoring data. Time series of annual average nitrate concentrations along with annual spatially distributed nitrate concentration maps from 1925 to 2150 were generated for 28 selected aquifer zones. The results show that 16 aquifer zones have an increasing trend in nitrate concentration, while average nitrate concentrations in the remaining 12 are declining. The results are also indicative of the trend in the flux of groundwater nitrate entering rivers through baseflow. The model thus enables the magnitude and timescale of groundwater nitrate response to be factored into source apportionment tools and to be taken into account alongside current planning of land-management options for reducing nitrate losses

Retinal boundary segmentation in stargardt disease optical coherence tomography images using automated deep learning

Purpose: To use a deep learning model to develop a fully automated method (fully semantic network and graph search [FS-GS]) of retinal segmentation for optical coherence tomography (OCT) images from patients with Stargardt disease. Methods: Eighty-seven manually segmented (ground truth) OCT volume scan sets (5171 B-scans) from 22 patients with Stargardt disease were used for training, validation and testing of a novel retinal boundary detection approach (FS-GS) that combines a fully semantic deep learning segmentation method, which generates a per-pixel class prediction map with a graph-search method to extract retinal boundary positions. The performance was evaluated using the mean absolute boundary error and the differences in two clinical metrics (retinal thickness and volume) compared with the ground truth. The performance of a separate deep learning method and two publicly available software algorithms were also evaluated against the ground truth. Results: FS-GS showed an excellent agreement with the ground truth, with a boundary mean absolute error of 0.23 and 1.12 pixels for the internal limiting membrane and the base of retinal pigment epithelium or Bruch's membrane, respectively. The mean difference in thickness and volume across the central 6 mm zone were 2.10 µm and 0.059 mm3. The performance of the proposed method was more accurate and consistent than the publicly available OCTExplorer and AURA tools. Conclusions: The FS-GS method delivers good performance in segmentation of OCT images of pathologic retina in Stargardt disease. Translational Relevance: Deep learning models can provide a robust method for retinal segmentation and support a high-throughput analysis pipeline for measuring retinal thickness and volume in Stargardt disease