A stochastic network with mobile users in heavy traffic

We consider a stochastic network with mobile users in a heavy-traffic regime. We derive the scaling limit of the multi-dimensional queue length process and prove a form of spatial state space collapse. The proof exploits a recent result by Lambert and Simatos which provides a general principle to establish scaling limits of regenerative processes based on the convergence of their excursions. We also prove weak convergence of the sequences of stationary joint queue length distributions and stationary sojourn times.Comment: Final version accepted for publication in Queueing Systems, Theory and Application

Construction of the stationary regime of queues with locking

AbstractWe consider a queueing system with N servers and two types of customers: Simple customers which require a service from one of the N servers and Locking customers which have to be served simultaneously by all N servers. Loyne's increasing schema is generalized to this type of queueing system. Various properties such as the stability condition and the uniqueness of the stationary regime are then derived

Stationary IPA Estimates for Non-Smooth G/G/1/∞\infty Functionals via Palm Inversion and Level-Crossing Analysis

We give stationary estimates for the derivative of the expectation of a non-smooth function of bounded variation f of the workload in a G/G/1/$\infty$ queue, with respect to a parameter influencing the distribu- tion of the input process. For this, we use an idea of Konstantopoulos and Zazanis based on the Palm inversion formula, however avoiding a limiting argument by performing the level-crossing analysis thereof globally, via Fubini's theorem. This method of proof allows to treat the case where the workload distribution has a mass at discontinuities of f and where the formula has to be modified. The case where the parameter is the speed of service or/and the time scale factor of the input process is also treated using the same approach

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele