A Systematic Literature Review of Animal-Assisted Interventions in Oncology (Part I): Methods and Results

Animal-assisted interventions (AAIs) use human-animal interactions to positive effect in various contexts including cancer care. As the first installment of a 2-part series, this systematic literature review focuses on the research methods and quantitative results of AAI studies in oncology. We find methodological consistency in the use of canines as therapy animals, in the types of high-risk patients excluded from studies, and in the infection precautions taken with therapy animals throughout cancer wards. The investigated patient endpoints are not significantly affected by AAI, with the exceptions of improvements in oxygen consumption, quality of life, depression, mood, and satisfaction with therapy. The AAI field in oncology has progressed significantly since its inception and has great potential to positively affect future patient outcomes. To advance the field, future research should consistently improve the methodological design of studies, report data more completely, and focus more on the therapy animal’s well-being

A Systematic Literature Review of Animal-Assisted Interventions in Oncology (Part II): Theoretical Mechanisms and Frameworks

Animal-assisted interventions (AAIs) can improve patients’ quality of life as complementary medical treatments. Part I of this 2-paper systematic review focused on the methods and results of cancer-related AAIs; Part II discusses the theories of the field’s investigators. Researchers cite animal personality, physical touch, physical movement, distraction, and increased human interaction as sources of observed positive outcomes. These mechanisms then group under theoretical frameworks such as the social support hypothesis or the human-animal bond concept to fully explain AAI in oncology. The cognitive activation theory of stress, the science of unitary human beings, and the self-object hypothesis are additional frameworks mentioned by some researchers. We also discuss concepts of neurobiological transduction connecting mechanisms to AAI benefits. Future researchers should base study design on theories with testable hypotheses and use consistent terminology to report results. This review aids progress toward a unified theoretical framework and toward more holistic cancer treatments

Materials for Sustainable Nuclear Energy - The Strategic Research Agenda (SRA) of the Joint Programme on Nuclear Materials (JPNM) of the European Energy Research Alliance (EERA)

This Strategic Research Agenda (SRA) has been prepared by the EERA-JPNM, based on a wide consultation with the scientific and industrial community involved, to identify the research lines to be pursued in the EU to ensure that suitable structural and fuel materials are available for the design, licensing, construction and safe long-term operation of GenIV nuclear systems. Three Grand Challenges have been identified, namely: (i) Elaborate design correlations, assessment and test procedures for the structural and fuel materials that have been selected for the demonstrators under the service conditions expected; (ii) Develop physical models coupled to advanced microstructural characterization to achieve high-level understanding and predictive capability; (iii) Develop innovative materials solutions and fabrication processes of industrial application to achieve superior materials properties, to increase safety and improve efficiency and economy. For structural materials, the requirement of 60 years design lifetime for non-replaceable components is in perspective the most demanding requirement, which includes under its umbrella several issues related with the reasonable prediction of long-term degradation processes: high temperature processes (creep, fatigue, thermal ageing), compatibility with –especially- heavy liquid metal and helium coolants, and effects of low flux prolonged irradiation, with emphasis on welded components in all cases. In terms of testing, there is a need for standardization, especially for sub-size and miniature specimens. The modelling, supported by microstructural characterization, has as its main objective the development of suitable microstructure evolution models to be used as input to models for the mechanical behaviour under irradiation and at high temperature, eventually linking with fracture mechanics. Specific developments are required for coolant compatibility models, as well as for models in support of the use of charged particle irradiation for the screening of new materials solutions, such as those listed above. Concerning fuel materials, the properties and processes that govern its behaviour in pile, on which research effort is focused, are: margin to melting (establishment of phase diagrams and evolution of thermal properties), atomic transport properties and ensuing microstructural evolution, fission product (non-gaseous) and helium (gas) behaviour and transport, mechanical properties (their evolution, subsequent fragmentation and cracking, fuel-cladding mechanical interaction), and compatibility with cladding and coolant (internal cladding corrosion, chemical interactions especially in case of severe accident). These are all addressed from both an experimental and a modelling perspective. Besides the obvious need of adequate financial resources in order to address the research problems outlined in this SRA, as well as the necessary corollaries, four recommendations emerge that this document is intended to bring to the attention of stake-holders, particularly decision-makers: R1: Data from materials property measurements after exposure to relevant conditions are the essential ingredient for robust design curves and rules. Plenty of data were produced in the past that are now de facto unusable; this is either because they are covered by confidentiality or because they were not properly archived. Correct data management to guarantee availability for future re-assessment is therefore essential and should be encouraged and fostered. In particular, financially supported policies to foster data sharing and encourage old data disclosure should be implemented. R2: Some infrastructures are absolutely essential to enable the correct qualification of nuclear materials, not only irradiation facilities, but also suitable ‘hot’ cells where active materials can be safely handled and tested, nuclearized characterization techniques, loops and pools for compatibility experiments, etc. They are also crucial for education and training of young researchers and operators. These infrastructures are costly to build and maintain. Other research facilities are, on the other hand, more common and sometimes redundant. A rational and harmonised, pan-European management of infrastructures, based on joint programming, including trans-national infrastructure renewal planning and a scheme for facility sharing and exploitation, would be highly desirable and, at the end of the day, beneficial for all. R3: International cooperation with non-EU countries where research on nuclear materials is pursued can be very valuable for Europe. Quite clearly, the goals of this cooperation are in the end the same as in the case of internal European cooperation, namely coordination of activities, sharing of data, and access to infrastructures. Currently, however, the instruments available in Europe for international cooperation are not sufficiently attractive to motivate significant cooperation with non-EU researchers. Efforts should be made to improve their attractiveness and ease of access. International organisations such as OECD.NEA, IAEA, but also Euratom and JRC for the connection with GIF, have here a crucial role. R4: The nuclear materials research community in Europe is currently strongly integrated and engaged in thriving collaboration, in a bottom-up sense. This is in contrast with the inadequacy of the top-down instruments offered to make this integration efficient and functional. This SRA is largely the result of matching bottom-up research proposals with top-down strategies. The appropriate instrument to allow this community to deliver according to the SRA goals should provide the conditions to implement the agreed research agenda and to set up suitable E&T&M schemes that allow knowledge, data, and facility sharing. Since the financial support of Euratom will never be sufficient, earmarked funding from the MS dedicated to support integrated research on nuclear materials is crucial. In this sense, a co-fund instrument, such as a European Joint Programme, seems to be most suitable.JRC.G.I.4-Nuclear Reactor Safety and Emergency Preparednes

TRY plant trait database – enhanced coverage and open access

Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait‐based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits—almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives

Rapid induction of single donor chimerism after double umbilical cord blood transplantation preceded by reduced intensity conditioning: results of the HOVON 106 phase II study

Double umbilical cord blood transplantation is increasingly applied in the treatment of adult patients with high-risk hematological malignancies and has been associated with improved engraftment as compared to that provided by single unit cord blood transplantation. The mechanism of improved engraftment is, however, still incompletely understood as only one unit survives. In this multicenter phase II study we evaluated engraftment, early chimerism, recovery of different cell lineages and transplant outcome in 53 patients who underwent double cord blood transplantation preceded by a reduced intensity conditioning regimen. Primary graft failure occurred in one patient. Engraftment was observed in 92% of patients with a median time to neutrophil recovery of 36 days (range, 15–102). Ultimate single donor chimerism was established in 94% of patients. Unit predominance occurred by day 11 after transplantation and early CD4(+) T-cell chimerism predicted for unit survival. Total nucleated cell viability was also associated with unit survival. With a median follow up of 35 months (range, 10–51), the cumulative incidence of relapse and non-relapse mortality rate at 2 years were 39% and 19%, respectively. Progressionfree survival and overall survival rates at 2 years were 42% (95% confidence interval, 28–56) and 57% (95% confidence interval, 43–70), respectively. Double umbilical cord blood transplantation preceded by a reduced intensity conditioning regimen using cyclophosphamide/fludarabine/4 Gy total body irradiation results in a high engraftment rate with low non-relapse mortality. Moreover, prediction of unit survival by early CD4(+) lymphocyte chimerism might suggest a role for CD4(+) lymphocyte mediated unit-versus-unit alloreactivity. www.trialregister.nl NTR1573