Paternal exposure to benzo(a)pyrene induces genome-wide mutations in mouse offspring

Understanding the effects of environmental exposures on germline mutation rates has been a decades-long pursuit in genetics. We used next-generation sequencing and comparative genomic hybridization arrays to investigate genome-wide mutations in the offspring of male mice exposed to benzo(a)pyrene (BaP), a common environmental pollutant. We demonstrate that offspring developing from sperm exposed during the mitotic or post-mitotic phases of spermatogenesis have significantly more de novo single nucleotide variants (1.8-fold; P < 0.01) than controls. Both phases of spermatogenesis are susceptible to the induction of heritable mutations, although mutations arising from post-fertilization events are more common after post-mitotic exposure. In addition, the mutation spectra in sperm and offspring of BaP-exposed males are consistent. Finally, we report a significant increase in transmitted copy number duplications (P = 0.001) in BaP-exposed sires. Our study demonstrates that germ cell mutagen exposures induce genome-wide mutations in the offspring that may be associated with adverse health outcomes

Investigations of the Mars Upper Atmosphere with ExoMars Trace Gas Orbiter

The Martian mesosphere and thermosphere, the region above about 60 km, is not the primary target of the ExoMars 2016 mission but its Trace Gas Orbiter (TGO) can explore it and address many interesting issues, either in-situ during the aerobraking period or remotely during the regular mission. In the aerobraking phase TGO peeks into thermospheric densities and temperatures, in a broad range of latitudes and during a long continuous period. TGO carries two instruments designed for the detection of trace species, NOMAD and ACS, which will use the solar occultation technique. Their regular sounding at the terminator up to very high altitudes in many different molecular bands will represent the first time that an extensive and precise dataset of densities and hopefully temperatures are obtained at those altitudes and local times on Mars. But there are additional capabilities in TGO for studying the upper atmosphere of Mars, and we review them briefly. Our simulations suggest that airglow emissions from the UV to the IR might be observed outside the terminator. If eventually confirmed from orbit, they would supply new information about atmospheric dynamics and variability. However, their optimal exploitation requires a special spacecraft pointing, currently not considered in the regular operations but feasible in our opinion. We discuss the synergy between the TGO instruments, specially the wide spectral range achieved by combining them. We also encourage coordinated operations with other Mars-observing missions capable of supplying simultaneous measurements of its upper atmosphere

Weather on Other Worlds. V. The Three Most Rapidly Rotating Ultra-cool Dwarfs

We present the discovery of rapid photometric variability in three ultra-cool dwarfs from long-duration monitoring with the Spitzer Space Telescope. The T7, L3.5, and L8 dwarfs have the shortest photometric periods known to date: 1.080-0.005+0.004 hr, 1.14-0.01+0.03 hr, and 1.23-0.01+0.01 hr, respectively. We confirm the rapid rotation through moderate-resolution infrared spectroscopy, which reveals projected rotational velocities between 79 and 104 km s-1. We compare the near-infrared spectra to photospheric models to determine the objects' fundamental parameters and radial velocities. We find that the equatorial rotational velocities for all three objects are ⪆100 km s-1. The three L and T dwarfs reported here are the most rapidly spinning and likely the most oblate field ultra-cool dwarfs known to date. Correspondingly, all three are excellent candidates for seeking auroral radio emission and net optical/infrared polarization. As of this writing, 78 L-, T-, and Y-dwarf rotation periods have now been measured. The clustering of the shortest rotation periods near 1 hr suggests that brown dwarfs are unlikely to spin much faster. © 2021. The American Astronomical Society. All rights reserved.Immediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]