Evaluating the metabolic approach to treatment of diabetic coronary patients

Diabetic patients with coronary artery disease have an altered myocardial metabolism of glucose and free fatty acids (FFA) and accelerated and diffuse atherogenesis with involvement of peripheral coronary segments that causes chronic hypoperfusion and hibernation. Therefore, in coronary diabetic patients the ischaemic metabolic changes that occur as a consequence of the mismatch between blood supply and cardiac metabolic requirements are heightened by the diabetic metabolic alterations. Important metabolic alterations in diabetic patients are the decreased utilization of glucose and the increase in muscular and myocardial FFA uptake and oxidation. These metabolic changes are responsible for the increased susceptibility of the diabetic heart to myocardial ischaemia and to a greater decrease of myocardial performance for a given amount of ischaemia compared to non diabetic hearts. A therapeutic approach aimed at an improvement of cardiac metabolism through manipulations of the utilization of metabolic substrates should result in an improvement of myocardial ischaemia and of left ventricular function. The inhibition of FFA oxidation improves cardiac metabolism at rest, increases the cardiac resistance to ischaemia and therefore reduces the decline of left ventricular function due to chronic hypoperfusion and repetitive episodes of myocardial ischaemia in patients with and without diabetes. Modulation of myocardial FFA metabolism should be the key target for metabolic interventions in diabetic patients with coronary artery disease

ODEF: an interactive tool for optimized design of EMI filters

The impact of EMI filters on volume and weight of power converters is significant. For this reason, filter’s size optimization is a strategic step towards the improvement of the power converter’s power density. An EMI filter design that follows a conventional procedure does not guarantee the selection of components/configuration leading to the best power density. Therefore, in order to help EMI engineers and scientists in pursuing a fast and effective choice of optimal discrete EMI filter components and configuration, a novel tool is proposed in this paper, namely ODEF (Optimized Design of EMI Filters). ODEF is an interactive software application running in Matlab® environment. It suitably improves a previously validated EMI filter design procedure that extends the conventional filter design method in order to achieve optimal power density. Features and operation of ODEF tool are illustrated. Moreover, the experimental assessment of an input EMI filter, designed according to the optimized procedure for an inverter-fed induction motor drive, is performed

Optimized design of high power density EMI filters for power electronic converters

Nowadays, power density of power converters and related EMI filters is gaining more and more attention. This severely impacts on the design constraints in several application domains. A conventional design of the EMI filter does not guarantee the selection of components/configuration leading to the best power density. For this reason, an optimized design procedure of discrete EMI filters in terms of power density is proposed in this paper. It is based on a previously developed rule-based design procedure, introducing here additional features to obtain a more effective optimization of EMI filter's power density. The proposed approach has been validated in terms of EMI filter's performance and size reduction, by a comparison between an EMI filter designed using the optimized procedure and a conventionally designed one, for two different case studies

Parameter Identification of a PV Source Dynamic Model with Piecewise-Linear Circuit-Based Approach

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Computer aided optimal design of high power density EMI filters

Power density of power converter systems is becoming an increasing crucial design constraint for a wide range of technical applications. Size reduction of EMI filter in power converters is an important challenge due to its significant impact on the overall converter volume and weight. In order to take on this issue, a computer aided procedure for a fast selection of optimal discrete EMI filter components and layout is described in this paper. The proposed technique is a rule-based automatic procedure based on a suitable database that considers the commercially available data sheets of passive components (e.g. magnetic cores, capacitors). It allows the minimization of the filter’s volume and therefore the improvement of the converter’s power density. The size and the performance of an EMI filter designed by using the proposed procedure, have been compared with those of a conventionally designed one. The comparison demonstrates the effectiveness of the proposed method

Diode laser-assisted surgical therapy for early treatment of oral mucocele in a newborn patient : case report and procedures checklist

Mucocele (also known as ranula or salivary gland mucous cyst) of the newborn is a lesion present on the intraoral cavity, with the potential to interfere with respiration and feeding. In the present report, a case of mucocele in a 4-month female patient has been described. As conventional surgery can be followed by several complications such as intraoperative bleeding, difficulties in wound healing, and maintenance of sterility during surgery, in the present case, the use of diode laser has been planned. A topic anesthesia with lidocaine gel was performed. A diode laser (810 nm wavelength, continuous wave mode, power output of 3 watt, and 0.4 mm diameter fiber optic) was set for excising the lesion. The tip was directed at an angle of 10 to 15\ub0, moving around the base of the lesion with a circular motion. The procedure was completed in 3 minutes. The patient was visited with a follow-up of 2 weeks and 4 months after excision. The intraoral wound healed without complications, and no signs of infection or mass recurrence were noted. The histopathological examination confirmed the diagnosis of mucocele. On the basis of the results of the present case report, the use of diode laser can be easily performed also in a noncompliant newborn patient for successful excision of mucocele lesions, and checklist of clinical procedures has been described

axl has a prognostic role in metastatic colorectal cancer mcrc and is a predictive biomarker of lack of efficacy of chemotherapy ct cetuximab in ras wild type wt patients pts

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Synergistic activity of everolimus and 5-aza-2'-deoxycytidine in medullary thyroid carcinoma cell lines

Medullary thyroid cancer (MTC) is a tumor highly resistant to chemo- and radiotherapy. Drug resistance can be induced by epigenetic changes such as aberrant DNA methylation. To overcome drug resistance, we explored a promising approach based on the use of 5-aza-2'-deoxycytidine (AZA), a demethylating agent, in combination with the mTOR inhibitor everolimus in MTC cells (MZ-CRC-1 and TT). This combined treatment showed a strong synergistic antiproliferative activity through the induction of apoptosis. The effect of everolimus and/or AZA on genome-wide expression profiling was evaluated by Illumina BeadChip in MZ-CRC-1 cells. An innovative bioinformatic pipeline identified four potential molecular pathways implicated in the synergy between AZA and everolimus: PI3K-Akt signaling, the neurotrophin pathway, ECM-receptor interaction and focal adhesion. Among these, the neurotrophin signaling pathway was most directly involved in apoptosis, through the overexpression of NGFR and Bax genes. The increased expression of genes involved in the NGFR-MAPK10-TP53-Bax/Bcl2 pathway during incubation with AZA plus everolimus was validated by western blotting in MZ-CRC-1 cells. Interestingly, addition of a neutralizing anti-NGFR antibody abolished the synergistic cytotoxic activity between AZA and everolimus. These results open a new therapeutic scenario for MTC and potentially other neuroendocrine tumors, where therapy with mTOR inhibitors is currently approved