956 research outputs found

    Insights into statin treatment of hypertriglyceridemia

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    Attention mechanisms in the CHREST cognitive architecture

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    In this paper, we describe the attention mechanisms in CHREST, a computational architecture of human visual expertise. CHREST organises information acquired by direct experience from the world in the form of chunks. These chunks are searched for, and verified, by a unique set of heuristics, comprising the attention mechanism. We explain how the attention mechanism combines bottom-up and top-down heuristics from internal and external sources of information. We describe some experimental evidence demonstrating the correspondence of CHREST’s perceptual mechanisms with those of human subjects. Finally, we discuss how visual attention can play an important role in actions carried out by human experts in domains such as chess

    The transcriptome of the salivary glands of the female western black-legged tick \u3cem\u3eIxodes pacificus\u3c/em\u3e (Acari: Ixodidae)

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    Sequencing of an Ixodes pacificus salivary gland cDNA library yielded 1068 sequences with an average undetermined nucleotide of 1.9% and an average length of 487 base pairs. Assembly of the expressed sequence tags yielded 557 contigs, 138 of which appear to code for secreted peptides or proteins based on translation of a putative signal peptide. Based on the BLASTX similarity of these contigs to 66 matches of Ixodes scapularis peptide sequences, only 58% sequence identity was found, indicating a rapid divergence of salivary proteins as observed previously for mosquito and triatomine bug salivary proteins. Here we report 106 mostly full-length sequences that clustered in 16 different families: Basic-tail proteins rich in lysine in the carboxy-terminal, Kunitz-containing proteins (monolaris, ixolaris and penthalaris families), proline-rich peptides, 5-, 9.4- and 18.7-kDa proteins of unknown functions, in addition to metalloproteases (class PIII-like) similar to reprolysins. We also have found a family of disintegrins, named ixodegrins that display homology to variabilin, a GPIIb/IIIa antagonist from the tick Dermacentor variabilis. In addition, we describe peptides (here named ixostatins) that display remarkable similarities to the cysteine-rich domain of ADAMST-4 (aggrecanase). Many molecules were assigned in the lipocalin family (histamine-binding proteins); others appear to be involved in oxidant metabolism, and still others were similar to ixodid proteins such as the anticomplement ISAC. We also identified for the first time a neuropeptide-like protein (nlp-31) with GGY repeats that may have antimicrobial activity. In addition, 16 novel proteins without significant similarities to other tick proteins and 37 housekeeping proteins that may be useful for phylogenetic studies are described. Some of these proteins may be useful for studying vascular biology or the immune system, for vaccine development, or as immunoreagents to detect prior exposure to ticks

    Wide binaries as a critical test of Classical Gravity

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    Modified gravity scenarios where a change of regime appears at acceleration scales a<a0a<a_{0} have been proposed. Since for 1M1 M_{\odot} systems the acceleration drops below a0a_{0} at scales of around 7000 AU, a statistical survey of wide binaries with relative velocities and separations reaching 10410^{4} AU and beyond should prove useful to the above debate. We apply the proposed test to the best currently available data. Results show a constant upper limit to the relative velocities in wide binaries which is independent of separation for over three orders of magnitude, in analogy with galactic flat rotation curves in the same a<a0a<a_{0} acceleration regime. Our results are suggestive of a breakdown of Kepler's third law beyond aa0a \approx a_{0} scales, in accordance with generic predictions of modified gravity theories designed not to require any dark matter at galactic scales and beyond.Comment: accepted for publication in EPJ

    Quantum properties of transverse pattern formation in second-harmonic generation

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    We investigate the spatial quantum noise properties of the one dimensional transverse pattern formation instability in intra-cavity second-harmonic generation. The Q representation of a quasi-probability distribution is implemented in terms of nonlinear stochastic Langevin equations. We study these equations through extensive numerical simulations and analytically in the linearized limit. Our study, made below and above the threshold of pattern formation, is guided by a microscopic scheme of photon interaction underlying pattern formation in second-harmonic generation. Close to the threshold for pattern formation, beams with opposite direction of the off-axis critical wave numbers are shown to be highly correlated. This is observed for the fundamental field, for the second harmonic field and also for the cross-correlation between the two fields. Nonlinear correlations involving the homogeneous transverse wave number, which are not identified in a linearized analysis, are also described. The intensity differences between opposite points of the far fields are shown to exhibit sub-Poissonian statistics, revealing the quantum nature of the correlations. We observe twin beam correlations in both the fundamental and second-harmonic fields, and also nonclassical correlations between them.Comment: 18 pages, 17 figures, submitted to Phys. Rev.

    DXA-derived hip shape is related to osteoarthritis:findings from in the MrOS cohort

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    BF conducted this research whilst on a clinical research primer fellowship awarded by the Elizabeth Blackwell Institute, University of Bristol, UK. This study was funded by Arthritis Research UK project grant ref 20244. CG is funded by Arthritis Research UK grant ref 20000. The Osteoporotic Fractures in Men (MrOS) Study is supported by National Institutes of Health funding. The following institutes provide support: the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research under the following grant numbers: R01 AR052000, K24 AR048841, U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128.Peer reviewedPostprin

    Coupled-channel effective field theory and proton-7^7Li scattering

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    We apply the renormalisation group (RG) to analyse scattering by short-range forces in systems with coupled channels. For two S-wave channels, we find three fixed points, corresponding to systems with zero, one or two bound or virtual states at threshold. We use the RG to determine the power countings for the resulting effective field theories. In the case of a single low-energy state, the resulting theory takes the form of an effective-range expansion in the strongly interacting channel. We also extend the analysis to include the effects of the Coulomb interaction between charged particles. The approach is then applied to the coupled p+7p+{^7}Li and n+7n+{^7}Be channels which couple to a JP=2J^P=2^- state of 8^8Be very close to the n+7n+{^7}Be threshold. At next-to-leading order, we are able to get a good description of the p+7p+{^7}Li phase shift and the 7{^7}Be(n,p)7{^7}Li cross section using four parameters. Fits at one order higher are similarly good but the available data are not sufficient to determine all five parameters uniquely.Comment: 22 pages, 2 figures, RevTeX4, typos corrected, accepted for publication in European Physical Journal

    Lepton flavor violation decays τμP1P2\tau^-\to \mu^- P_1 P_2 in the topcolor-assisted technicolor model and the littlest Higgs model with TT parity

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    The new particles predicted by the topcolor-assisted technicolor (TC2TC2) model and the littlest Higgs model with T-parity (called LHTLHT model) can induce the lepton flavor violation (LFVLFV) couplings at tree level or one loop level, which might generate large contributions to some LFVLFV processes. Taking into account the constraints of the experimental data on the relevant free parameters, we calculate the branching ratios of the LFVLFV decay processes τμP1P2\tau^-\to\mu^- P_1 P_2 with P1P2P_1 P_2 = π+π\pi^+\pi^-, K+KK^+K^- and K0K0ˉK^0\bar{K^0} in the context of these two kinds of new physics models. We find that the TC2TC2 model and the LHTLHT model can indeed produce significant contributions to some of these LFVLFV decay processes.Comment: 24 pages, 7 figure
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