68 research outputs found
Edge states and determination of pairing symmetry in superconducting Sr2RuO4
We calculate the energy dispersion of the surface Andreev states and their
contribution to tunneling conductance for the order parameters with horizontal
and vertical lines of nodes proposed for superconducting Sr2RuO4. For vertical
lines, we find double peaks in tunneling spectra reflecting the van Hove
singularities in the density of surface states originating from the turning
points in their energy dispersion. For horizontal lines, we find a single
cusp-like peak at zero bias, which agrees very well with the experimental data
on tunneling in Sr2RuO4.Comment: 6 pages, 6 figures. V.2: comparison with experiment added and
discussion of horizontal nodes expanded. v.3: significant expansion: 1 figure
and 2 pages added. v.4: acknowledgements added. Additional viewgraphs with
experimental and theoretical curves superimposed are available at
http://www2.physics.umd.edu/~yakovenk/talks/Sr2RuO4
Nivolumab Alone and With Ipilimumab in Previously Treated Metastatic Urothelial Carcinoma: CheckMate 032 Nivolumab 1 mg/kg Plus Ipilimumab 3 mg/kg Expansion Cohort Results
PURPOSE CheckMate 032 is an open-label, multicohort study that includes patients with unresectable locally advanced or metastatic urothelial carcinoma (mUC) treated with nivolumab 3 mg/kg monotherapy every 2 weeks (NIVO3), nivolumab 3 mg/kg plus ipilimumab 1 mg/kg every 3 weeks for four doses followed by nivolumab monotherapy 3 mg/kg every 2 weeks (NIVO3+IPI1), or nivolumab 1 mg/kg plus ipilimumab 3 mg/kg every 3 weeks for four doses followed by nivolumab monotherapy 3 mg/kg every 2 weeks (NIVO1+IPI3). We report on the expanded NIVO1+IPI3 cohort and extended follow-up for the NIVO3 and NIVO3+IPI1 cohorts.
METHODS Patients with platinum-pretreated mUC were enrolled in this phase I/II multicenter study to receive NIVO3, NIVO3+IPI1, or NIVO1+IPI3 until disease progression or unacceptable toxicity. Primary end point was investigator-assessed objective response rate per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, including duration of response.
RESULTS Seventy-eight patients were treated with NIVO3 (minimum follow-up, 37.7 months), 104 with NIVO3+IPI1 (minimum follow-up, 38.8 months), and 92 with NIVO1+IPI3 (minimum follow-up, 7.9 months). Objective response rate was 25.6%, 26.9%, and 38.0% in the NIVO3, NIVO3+IPI1, and NIVO1+IPI3 arms, respectively. Median duration of response was more than 22 months in all arms. Grade 3 or 4 treatment-related adverse events occurred in 21 (26.9%), 32 (30.8%), and 36 (39.1%) patients treated with NIVO3, NIVO3+IPI1, and NIVO1+IPI3, respectively. Grade 5 treatment-related pneumonitis occurred in one patient each in the NIVO3 and NIVO3+IPI1 arms.
CONCLUSION With longer follow-up, NIVO3 demonstrated sustained antitumor activity alone and in combination with ipilimumab. NIVO1+IPI3 provided the greatest antitumor activity of all regimens, with a manageable safety profile. This result not only supports additional study of NIVO1+IPI3 in mUC, but demonstrates the potential benefit of immunotherapy combinations in this disease
Polarization correlation in the two-photon decay of atomic hydrogen: nonlocality versus entanglement
Use of Nonantiretroviral Medications That May Impact Neurocognition: Patterns and Predictors in a Large, Long-Term HIV Cohort Study
Background: Neurocognitive impairment is a frequent and often disabling comorbidity of HIV infection. In addition to antiretroviral therapies, individuals with HIV infection may commonly use nonantiretroviral medications that are known to cause neurocognitive adverse effects (NC-AE). The contribution of NC-AE to neurocognitive impairment is rarely considered in the context of HIV and could explain part of the variability in neurocognitive performance among individuals with HIV. Setting: Womenâs Interagency HIV Study, a prospective, multisite, observational study of US women with and without HIV. Methods: After a literature review, 79 medications (excluding statins) with NC-AE were identified and reported by Womenâs Interagency HIV Study participants. We examined factors associated with self-reported use of these medications over a 10-year period. Generalized estimating equations for binary outcomes were used to assess sociodemographic, behavioral, and clinical characteristics associated with NC-AE medication use. Results: Three thousand three hundred women (71% with HIV) and data from ~42,000 visits were studied. HIV infection was associated with NC-AE medication use (odds ratio = 1.52; 95% confidence interval: 1.35 to 1.71). After adjustment for HIV infection status, other predictors of NC-AE medication use included having health insurance, elevated depressive symptoms, prior clinical AIDS, noninjection recreational drug use, and an annual household income of <$12,000 (Ps < 0.004). NC-AE medication use was less likely among women who drank 1â7 or 8â12 alcoholic drinks/week (vs. abstaining) (P < 0.04). Conclusions: HIV infection was associated with NC-AE medication use, which may influence determinations of HIV-associated neurocognitive impairment. Providers should consider the impact of NC-AE medications when evaluating patients with HIV and concurrent neurocognitive symptoms
Electron Dynamics in NdCeCuO: Evidence for the Pseudogap State and Unconventional c-axis Response
Infrared reflectance measurements were made with light polarized along the a-
and c-axis of both superconducting and antiferromagnetic phases of electron
doped NdCeCuO. The results are compared to
characteristic features of the electromagnetic response in hole doped cuprates.
Within the CuO planes the frequency dependent scattering rate,
1/, is depressed below 650 cm; this behavior is a
hallmark of the pseudogap state. While in several hole doped compounds the
energy scales associated with the pseudogap and superconducting states are
quite close, we are able to show that in NdCeCuO
the two scales differ by more than one order of magnitude. Another feature of
the in-plane charge response is a peak in the real part of the conductivity,
, at 50-110 cm which is in sharp contrast with the
Drude-like response where is centered at . This
latter effect is similar to what is found in disordered hole doped cuprates and
is discussed in the context of carrier localization. Examination of the c-axis
conductivity gives evidence for an anomalously broad frequency range from which
the interlayer superfluid is accumulated. Compelling evidence for the pseudogap
state as well as other characteristics of the charge dynamics in
NdCeCuO signal global similarities of the cuprate
phase diagram with respect to electron and hole doping.Comment: Submitted to PR
The Psychological Science Acceleratorâs COVID-19 rapid-response dataset
In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data
The Psychological Science Acceleratorâs COVID-19 rapid-response dataset
In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data
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